Photocatalytic C–P bond formation based on the reaction of carbon-centered radicals with phosphides

Abstract

Organophosphorus compounds hold significant importance in the fields of materials science, medicinal chemistry, pesticides and organic synthesis. In particular, phosphonate esters can be used in sensors, antibacterial and anti-virus drugs, herbicides and organic phosphine ligands, etc. Therefore, the construction of C–P bonds has attracted tremendous attention from chemists. Although strategies for the photocatalytic synthesis of phosphonate esters have been reported, they are mainly limited to the reaction of phosphorus radicals with carbon-containing organic compounds. In recent years, with the rapid development of photocatalysis, organic chemists have made remarkable progress in the study of visible light-mediated carbon-centered radical phosphorylation, especially the construction of C(sp³)–P bonds based on alkyl radicals. This review focuses on the synthesis of C–P bonds using carbon-centered radicals with phosphorous compounds of different valence states (P^III, P^V, P₄) under photocatalysis.