Issue 14, 2024

Precision single-atom editing: new frontiers in nitrogen insertion and substitution for the generation of N-heterocycles

Abstract

Single-atom editing, which involves precise modifications to a ring system through the selective insertion, deletion or substitution of atoms, represents a crucial advancement in the manipulation of chemically active molecules. This review focuses primarily on the editing of nitrogen atoms, including the insertion of N, the substitution of C with N and 14N with 15N for the construction of N-heterocycles. The emphasis on the nitrogen source facilitates a deeper understanding of the reactions involved. We anticipate that this review will not only underscore the innovative and enabling capabilities of current nitrogen single-atom editing techniques but also highlight the significant opportunities and untapped possibilities within this emerging and valuable field.

Graphical abstract: Precision single-atom editing: new frontiers in nitrogen insertion and substitution for the generation of N-heterocycles

Article information

Article type
Review Article
Submitted
08 May 2024
Accepted
06 Jun 2024
First published
17 Jun 2024

Org. Chem. Front., 2024,11, 4041-4053

Precision single-atom editing: new frontiers in nitrogen insertion and substitution for the generation of N-heterocycles

X. Li, J. Xu and Z. Xu, Org. Chem. Front., 2024, 11, 4041 DOI: 10.1039/D4QO00812J

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