Unveiling the beauty of cyclopropane formation: a comprehensive survey of enantioselective Michael initiated ring closure (MIRC) reactions

Abstract

This review presents a comprehensive overview of the synthesis of cyclopropanes using enantioselective Michael Initiated Ring Closure (MIRC) reactions. Cyclopropane-containing compounds possess unique structural and chemical properties that render them valuable in various fields, such as medicine, agrochemistry, and materials science. The MIRC approach has emerged as a versatile and efficient method for generating cyclopropane rings with excellent enantioselectivity. The review details fundamental concepts, reaction mechanisms, and synthetic strategies employed in MIRC reactions. A short introduction is provided to highlight the use of chiral substrates and nucleophiles to synthesize enantioenriched cyclopropanes. Additionally, recent advancements, challenges, and future prospects in the field are also discussed. This review serves as a valuable resource for researchers and practitioners interested in harnessing the potential of MIRC reactions for the synthesis of chiral cyclopropane derivatives, offering a comprehensive and up-to-date overview of the subject matter.