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Themed collection New Talent

26 items
Review Article

Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals

The review highlights the recent advances (2013-present) in the use of earth-abundant first row transition metals in homogeneous borrowing hydrogen catalysis.

Graphical abstract: Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals
From the themed collection: New Talent
Communication

Identification of a lysine 4-hydroxylase from the glidobactin biosynthesis and evaluation of its biocatalytic potential

We present the functional characterization of GlbB, a lysine 4-hydroxylase from the glidobactin biosynthetic gene cluster.

Graphical abstract: Identification of a lysine 4-hydroxylase from the glidobactin biosynthesis and evaluation of its biocatalytic potential
From the themed collection: Chemical biology in OBC
Accepted Manuscript - Communication

Synthesis of the β-linked GalNAc-Kdo Disaccharide Antigen of the Capsular Polysaccharide of Kingella kingae KK01

From the themed collection: New Talent
Communication

Palladium-catalyzed intramolecular carboborylation of 1,3-diene and synthesis of ABCD ring of communesins

A palladium-catalyzed intramolecular carboborylation of 1,3-diene has been developed for the synthesis of iminoindolines with a quaternary carbon centre.

Graphical abstract: Palladium-catalyzed intramolecular carboborylation of 1,3-diene and synthesis of ABCD ring of communesins
From the themed collection: New Talent
Communication

Synthesis of the core structure of phalarine

Two new palladium-catalyzed reactions enabled the synthesis of the core structure of phalarine.

Graphical abstract: Synthesis of the core structure of phalarine
From the themed collection: New Talent
Communication

Robust Buchwald–Hartwig amination enabled by ball-milling

An operationally simple mechanochemical method for the Pd catalysed Buchwald–Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system.

Graphical abstract: Robust Buchwald–Hartwig amination enabled by ball-milling
From the themed collection: New Talent
Communication

Organocatalytic asymmetric Michael/hemiketalization/acyl transfer reaction of 1,3-propanediones with (E)-2-(2-nitrovinyl)phenols

An organocatalytic asymmetric cascade Michael/hemiketalization/acyl transfer reaction between (E)-2-(2-nitrovinyl)phenols and 1,3-propanediones is disclosed to generate products having keto, ester and nitro functionalities.

Graphical abstract: Organocatalytic asymmetric Michael/hemiketalization/acyl transfer reaction of 1,3-propanediones with (E)-2-(2-nitrovinyl)phenols
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

The first regioselective MBH-type α-alkylation of α,β,γ,δ-unsaturated aldehydes is achieved using diarylcarbinols with an excellent E/Z selectivity under mild reaction conditions.

Graphical abstract: Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes
From the themed collection: Synthetic methodology in OBC
Communication

Palladium-catalyzed salt-free double decarboxylative aryl allylation

We describe a palladium catalyzed salt-free decarboxylative aryl allylation of free benzoic acids with allyl tert-butyl-carbonates.

Graphical abstract: Palladium-catalyzed salt-free double decarboxylative aryl allylation
From the themed collection: New Talent
Communication

Synthesis of hydrophobic insulin-based peptides using a helping hand strategy

A universal “helping hand” to facilitate the synthesis of A chain of insulin-related peptides.

Graphical abstract: Synthesis of hydrophobic insulin-based peptides using a helping hand strategy
From the themed collection: New Talent
Open Access Communication

Total synthesis of incargranine A

Synthetic studies into the origins of the alkaloid incargranine A have resulted in the development of a four-step (longest linear sequence) total synthesis.

Graphical abstract: Total synthesis of incargranine A
From the themed collection: New Talent
Paper

Rh-Catalyzed diastereoselective desymmetrization of enone tethered-cyclohexadienones via tandem arylative cyclization

The rhodium-catalyzed arylative cyclization of enone tethered-cyclohexadienones has been developed with high efficiency, thus providing cis-fused bicyclic enones in good yields and with excellent diastereoselectivities.

Graphical abstract: Rh-Catalyzed diastereoselective desymmetrization of enone tethered-cyclohexadienones via tandem arylative cyclization
From the themed collection: Synthetic methodology in OBC
Accepted Manuscript - Paper

Metal-free Photocatalytic Thiol-Ene/Thiol-Yne Reactions

From the themed collection: New Talent
Accepted Manuscript - Paper

Reversibly photoswitchable alkoxy azobenzenes connected benzenetricarboxamide discotic liquid crystals with perpetual long range columnar assembly

From the themed collection: New Talent
Paper

Sulfur polymer composites as controlled-release fertilisers

A controlled-release fertiliser was prepared by the inverse vulcanisation of canola oil in the presence of nitrogen, phosphorous and potassium nutrients.

Graphical abstract: Sulfur polymer composites as controlled-release fertilisers
From the themed collection: New Talent
Paper

Regiospecific formal [3 + 2] annulation of tert-propargyl alcohols with acyclic 1,3-diketones via the cycloisomerization of homoallenyl ketones

A one-pot, regiospecific synthesis of dihydrofurans bearing a quaternary centre is developed from the formal [3 + 2] annulation of tert-propargyl alcohols and 1,3-diketones through the SN2I mechanism to form homoallenyl ketone and a subsequent cycloisomerization reaction.

Graphical abstract: Regiospecific formal [3 + 2] annulation of tert-propargyl alcohols with acyclic 1,3-diketones via the cycloisomerization of homoallenyl ketones
From the themed collection: Synthetic methodology in OBC
Paper

Understanding the axial chirality control of quinidine-derived ammonium cation-directed O-alkylation: a computational study

DFT calculations reveal the origins of axial chirality control by cinchona alkaloid derivatives.

Graphical abstract: Understanding the axial chirality control of quinidine-derived ammonium cation-directed O-alkylation: a computational study
From the themed collection: New Talent
Paper

A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede

Structural modulation of the fluorescent protein (FP) chromophore to enable fluorogenic probe for SNAP-tag towards wash-free live cell imaging.

Graphical abstract: A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede
From the themed collection: Chemical biology in OBC
Paper

Boronic acid-catalysed C-3 selective ring opening of 3,4-epoxy alcohols with thiophenols and thiols

A boronic acid-catalysed C-3 selective ring opening of 3,4-epoxy alcohols with thiophenols and thiols as nucleophiles has been accomplished.

Graphical abstract: Boronic acid-catalysed C-3 selective ring opening of 3,4-epoxy alcohols with thiophenols and thiols
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus

Human milk oligosaccharides (HMOs) possess antimicrobial activity against a number of bacterial pathogens.

Graphical abstract: Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus
From the themed collection: Chemical biology in OBC
Paper

Enantioselective syntheses and application of 4-epi-galiellalactone and the corresponding activity-based probe: from strained bicycles to strained tricycles

Efficient syntheses of 4-epi-galiellalactone and the corresponding activity-based probe enabled chemoproteomic studies to reveal the biological targets.

Graphical abstract: Enantioselective syntheses and application of 4-epi-galiellalactone and the corresponding activity-based probe: from strained bicycles to strained tricycles
From the themed collection: Chemical biology in OBC
Paper

Why do A·T and G·C self-sort? Hückel aromaticity as a driving force for electronic complementarity in base pairing

Computations reveal that the potential for aromaticity gain and loss in nucleobases play key roles in modulating base pairing strengths.

Graphical abstract: Why do A·T and G·C self-sort? Hückel aromaticity as a driving force for electronic complementarity in base pairing
From the themed collection: New Talent
Paper

A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells

Peroxynitrite (ONOO) is involved in a variety of physiological and pathological processes.

Graphical abstract: A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells
From the themed collection: New Talent
Paper

Design, synthesis, and biological evaluation of C7-functionalized DMXAA derivatives as potential human-STING agonists

A strategy to diversely functionalize the C7-position of DMXAA has been developed as a means to discover potential human-STING agonists.

Graphical abstract: Design, synthesis, and biological evaluation of C7-functionalized DMXAA derivatives as potential human-STING agonists
From the themed collection: Chemical biology in OBC
Open Access Paper

Studies on a landscape of perfluoroaromatic-reactive peptides

Diverse peptide sequences and folds promote cysteine arylation.

Graphical abstract: Studies on a landscape of perfluoroaromatic-reactive peptides
From the themed collection: New Talent
Paper

An elusive thermal [2 + 2] cycloaddition driven by visible light photocatalysis: tapping into strain to access C2-symmetric tricyclic rings

A mild and operationally simple methodology is reported for the synthesis of cyclobutane rings imbedded within a C2-symmetric tricyclic framework.

Graphical abstract: An elusive thermal [2 + 2] cycloaddition driven by visible light photocatalysis: tapping into strain to access C2-symmetric tricyclic rings
From the themed collection: New Talent
26 items

About this collection

This issue aims to highlight the excellent work being carried out by younger members of the research community.
It will cover topics including organic synthesis, physical organic chemistry, supramolecular chemistry and chemical biology, and showcase the strength of research being carried out by tomorrow's leaders in the field.
Articles in this themed issue will be added below as soon as possible after they are published. Please return to this page frequently to see the collection grow.

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