Themed collection New Talent

69 items
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From the themed collection: New Talent
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From the themed collection: New Talent
Review Article

Hetero-bimetallic cooperative catalysis for the synthesis of heteroarenes

Review covering the synthesis of 5- and 6-membered as well as condensed heteroarenes, focussing on the combinations in cooperative catalytic systems in strategies used to achieve selectivity and also highlights the mode of action for the cooperative catalysis leading to the synthesis of commercially and biologically relevant heteroarenes.

Graphical abstract: Hetero-bimetallic cooperative catalysis for the synthesis of heteroarenes
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Use of ArSO2SRf reagents: an efficient tool for the introduction of SRf moieties

This review discusses the use of several ArSO2SRf reagents as SRf sources, an emerging trend to access SRf-containing molecules.

Graphical abstract: Use of ArSO2SRf reagents: an efficient tool for the introduction of SRf moieties
From the themed collection: Synthetic methodology in OBC
Review Article

Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials

Peptide–oligonucleotide conjugates (POCs) are covalent constructs that link a molecule like DNA to a synthetic peptide sequences.

Graphical abstract: Emerging applications of peptide–oligonucleotide conjugates: bioactive scaffolds, self-assembling systems, and hybrid nanomaterials
From the themed collection: Chemical Biology in OBC
Review Article

Beyond the traditional roles of Ag in catalysis: the transmetalating ability of organosilver(I) species in Pd-catalysed reactions

The role of silver salts in Pd-catalysed C–C bond forming transformations.

Graphical abstract: Beyond the traditional roles of Ag in catalysis: the transmetalating ability of organosilver(i) species in Pd-catalysed reactions
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Intermolecular alkene difunctionalizations for the synthesis of saturated heterocycles

Intermolecular alkene difunctionalizations for the direct synthesis of saturated heterocycles.

Graphical abstract: Intermolecular alkene difunctionalizations for the synthesis of saturated heterocycles
From the themed collection: Synthetic methodology in OBC
Review Article

The challenge of using isopropylamine as an amine donor in transaminase catalysed reactions

Factors that affect the efficiency of amine transaminase catalyzed reactions using isopropylamine as an amine donor.

Graphical abstract: The challenge of using isopropylamine as an amine donor in transaminase catalysed reactions
From the themed collection: Catalysis & biocatalysis in OBC
Review Article

Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects

Rearranged ergostane-type natural products are structurally intriguing and exhibit biologically relevant properties.

Graphical abstract: Rearranged ergostane-type natural products: chemistry, biology, and medicinal aspects
From the themed collection: Chemical Biology in OBC
Review Article

Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity

Diversity-oriented synthesis adds biological performance as a new diversity element.

Graphical abstract: Next generation diversity-oriented synthesis: a paradigm shift from chemical diversity to biological diversity
From the themed collection: Synthetic methodology in OBC
Open Access Review Article

Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals

The review highlights the recent advances (2013-present) in the use of earth-abundant first row transition metals in homogeneous borrowing hydrogen catalysis.

Graphical abstract: Recent advances in homogeneous borrowing hydrogen catalysis using earth-abundant first row transition metals
From the themed collection: Synthetic methodology in OBC
Communication

Photoinduced decarboxylative azidation of cyclic amino acids

The direct decarboxylative azidation of cyclic α-amino acids has been achieved via visible light-mediated organo-photoredox catalysis.

Graphical abstract: Photoinduced decarboxylative azidation of cyclic amino acids
From the themed collection: Synthetic methodology in OBC
Communication

ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

We report a high-affinity photoswitchable DNA binder, which displays different nucleosome-binding capacities upon visible-light irradiation.

Graphical abstract: ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light
From the themed collection: Chemical Biology in OBC
Communication

Iron catalysed selective reduction of esters to alcohols

Exposure of BIANFeCl2 to nBuLi generates an anionic complex which is a competent catalyst for the selective reduction of esters to alcohols.

Graphical abstract: Iron catalysed selective reduction of esters to alcohols
From the themed collection: Catalysis & biocatalysis in OBC
Communication

A fluorogenic C4N4 probe for azide-based labelling

A new fluorogenic probe based on the recently identified 2,5-diaminopyrimidine (C4N4) fluorophore is introduced for azide-specific labelling.

Graphical abstract: A fluorogenic C4N4 probe for azide-based labelling
From the themed collection: Chemical Biology in OBC
Communication

Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors

Herein we report synthesis of complex heparan sulfate oligosaccharide precursors by automated glycan assembly using disaccharide donor building blocks.

Graphical abstract: Using automated glycan assembly (AGA) for the practical synthesis of heparan sulfate oligosaccharide precursors
From the themed collection: New Talent
Communication

Formal [4 + 2] benzannulation of 2-alkenyl indoles with aldehydes: a route to structurally diverse carbazoles and bis-carbazoles

Construction of structurally diverse carbazoles and bis-carbazoles by protecting-group-free formal [4 + 2]-benzannulation of 2-alkenyl indoles and aldehydes is demonstrated.

Graphical abstract: Formal [4 + 2] benzannulation of 2-alkenyl indoles with aldehydes: a route to structurally diverse carbazoles and bis-carbazoles
From the themed collection: Synthetic methodology in OBC
Communication

Radical SAM-dependent adenosylation catalyzed by L-tyrosine lyases

Tyrosine analogues containing an olefin moiety can be adenosylated by L-tyrosine lyases.

Graphical abstract: Radical SAM-dependent adenosylation catalyzed by l-tyrosine lyases
From the themed collection: Chemical Biology in OBC
Communication

Vinylogous acyl triflates as an entry point to α,β-disubstituted cyclic enones via Suzuki–Miyaura cross-coupling

An alternative protocol for the B-alkyl Suzuki–Miyaura reaction to produce cyclic α,β-disubstituted enones is reported.

Graphical abstract: Vinylogous acyl triflates as an entry point to α,β-disubstituted cyclic enones via Suzuki–Miyaura cross-coupling
From the themed collection: Synthetic methodology in OBC
Communication

An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis

Herein we describe the direct enantioselective Lewis base/Pd catalysed α-allylation of pyrrole acetic acid esters.

Graphical abstract: An enantioselective synthesis of α-alkylated pyrroles via cooperative isothiourea/palladium catalysis
From the themed collection: Synthetic methodology in OBC
Communication

Posttranscriptional spin labeling of RNA by tetrazine-based cycloaddition

Spin labeling of in vitro transcribed RNA by iEDDA click chemistry is demonstrated. This allows the determination of distance distributions between two nitroxide spin labels by PELDOR in a self-complementary RNA duplex.

Graphical abstract: Posttranscriptional spin labeling of RNA by tetrazine-based cycloaddition
From the themed collection: Chemical Biology in OBC
Communication

Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction

Direct arylation and heteroarylation of unprotected tetrahydroisoquinolines were achieved under conditions free of metals, oxidants and solvents.

Graphical abstract: Direct (het)arylation of tetrahydroisoquinolines via a metal and oxidant free C(sp3)–H functionalization enabled three component reaction
From the themed collection: Synthetic methodology in OBC
Communication

Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA

A fluorescent peptide displacement assay combined with statistical analysis is used for screening small molecules against different RNA targets and profiling their affinity/selectivity patterns.

Graphical abstract: Fluorescent peptide displacement as a general assay for screening small molecule libraries against RNA
From the themed collection: Chemical Biology in OBC
Communication

Copper-catalyzed arene amination in pure aqueous ammonia

A simple protocol for copper-catalyzed arene amination using aqueous ammonia without any additional ligands and organic coordinating solvents has been developed.

Graphical abstract: Copper-catalyzed arene amination in pure aqueous ammonia
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Mechanism of nitrones and allenoates cascade reactions for the synthesis of dihydro[1,2-a]indoles

Quantum mechanical calculations (DLPNO-CCSD(T) and M06-2X) are employed to gain insights into the mechanism and selectivity in the catalytic synthesis of dihydropyrido[1,2-a]indoles from the cascade reaction between nitrones and allenes.

Graphical abstract: Mechanism of nitrones and allenoates cascade reactions for the synthesis of dihydro[1,2-a]indoles
Communication

Multicomponent dipolar cycloadditions: efficient synthesis of polycyclic fused pyrrolizidines via azomethine ylides

An efficient multicomponent dipolar cycloaddition for the synthesis of polycyclic fused pyrrolizidines was developed using N-aromatic zwitterions, aldehydes, and amino acids.

Graphical abstract: Multicomponent dipolar cycloadditions: efficient synthesis of polycyclic fused pyrrolizidines via azomethine ylides
From the themed collection: Synthetic methodology in OBC
Communication

Synthesis of fluoroalkylated alkynes via visible-light photocatalysis

Fluoroalkylated alkynes, which are versatile building blocks for the synthesis of various biologically active organofluorine compounds, were synthesized from easily available alkynyl halides and fluoroalkyl halides by visible-light photocatalysis.

Graphical abstract: Synthesis of fluoroalkylated alkynes via visible-light photocatalysis
From the themed collection: Synthetic methodology in OBC
Communication

Total synthesis of (±)-antroquinonol

We report the total synthesis of (±)-antroquinonol based on a concise and efficient route.

Graphical abstract: Total synthesis of (±)-antroquinonol
From the themed collection: Total synthesis in OBC
Communication

Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

Chiral selenide-catalyzed enantioselective trifluoromethylthiolation of 1,1-disubstituted alkenes is disclosed. Various chiral trifluoromethylthiolated 2,5-disubstituted oxazolines were obtained in good yields with high enantioselectivities.

Graphical abstract: Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines
From the themed collection: Synthetic methodology in OBC
Communication

Iron-catalyzed protodehalogenation of alkyl and aryl halides using hydrosilanes

A simple and efficient iron-catalyzed protodehalogenation of alkyl and aryl halides using phenylhydrosilane is disclosed.

Graphical abstract: Iron-catalyzed protodehalogenation of alkyl and aryl halides using hydrosilanes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Selective alkyl ether cleavage by cationic bis(phosphine)iridium complexes

Simple cationic bis(phosphine)iridium complexes are shown to be highly selective catalysts for ether cleavage with silanes. Benzylic ethers can be cleaved under mild conditions in the presence of reductively-labile functional groups.

Graphical abstract: Selective alkyl ether cleavage by cationic bis(phosphine)iridium complexes
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Oxidative cross-dehydrogenative [2 + 3] annulation of α-amino ketones with α-keto esters: concise synthesis of clausenamide analogues

A one-pot oxidative cross-dehydrogenative [2 + 3] annulation of α-amino ketones with α-keto esters at room temperature is reported.

Graphical abstract: Oxidative cross-dehydrogenative [2 + 3] annulation of α-amino ketones with α-keto esters: concise synthesis of clausenamide analogues
From the themed collection: Synthetic methodology in OBC
Communication

Synthesis of the β-linked GalNAc-Kdo disaccharide antigen of the capsular polysaccharide of Kingella kingae KK01

TfOH-catalyzed glycosylation with D-galactosaminyl N-phenyl trifluoroacetimidate as the donor was developed for the construction of the challenging β-(1 → 5)-linked GalNAc-Kdo disaccharide antigen from Kingella kingae KK01.

Graphical abstract: Synthesis of the β-linked GalNAc-Kdo disaccharide antigen of the capsular polysaccharide of Kingella kingae KK01
From the themed collection: Chemical Biology in OBC
Communication

Identification of a lysine 4-hydroxylase from the glidobactin biosynthesis and evaluation of its biocatalytic potential

We present the functional characterization of GlbB, a lysine 4-hydroxylase from the glidobactin biosynthetic gene cluster.

Graphical abstract: Identification of a lysine 4-hydroxylase from the glidobactin biosynthesis and evaluation of its biocatalytic potential
From the themed collection: Chemical Biology in OBC
Communication

Palladium-catalyzed intramolecular carboborylation of 1,3-diene and synthesis of ABCD ring of communesins

A palladium-catalyzed intramolecular carboborylation of 1,3-diene has been developed for the synthesis of iminoindolines with a quaternary carbon centre.

Graphical abstract: Palladium-catalyzed intramolecular carboborylation of 1,3-diene and synthesis of ABCD ring of communesins
From the themed collection: Total synthesis in OBC
Communication

Synthesis of the core structure of phalarine

Two new palladium-catalyzed reactions enabled the synthesis of the core structure of phalarine.

Graphical abstract: Synthesis of the core structure of phalarine
From the themed collection: Total synthesis in OBC
Open Access Communication

Robust Buchwald–Hartwig amination enabled by ball-milling

An operationally simple mechanochemical method for the Pd catalysed Buchwald–Hartwig amination of arylhalides with secondary amines has been developed using a Pd PEPPSI catalyst system.

Graphical abstract: Robust Buchwald–Hartwig amination enabled by ball-milling
From the themed collection: Synthetic methodology in OBC
Communication

Organocatalytic asymmetric Michael/hemiketalization/acyl transfer reaction of 1,3-propanediones with (E)-2-(2-nitrovinyl)phenols

An organocatalytic asymmetric cascade Michael/hemiketalization/acyl transfer reaction between (E)-2-(2-nitrovinyl)phenols and 1,3-propanediones is disclosed to generate products having keto, ester and nitro functionalities.

Graphical abstract: Organocatalytic asymmetric Michael/hemiketalization/acyl transfer reaction of 1,3-propanediones with (E)-2-(2-nitrovinyl)phenols
From the themed collection: Catalysis & biocatalysis in OBC
Communication

Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes

The first regioselective MBH-type α-alkylation of α,β,γ,δ-unsaturated aldehydes is achieved using diarylcarbinols with an excellent E/Z selectivity under mild reaction conditions.

Graphical abstract: Highly regioselective α-alkylation of α,β,γ,δ-unsaturated aldehydes
From the themed collection: Synthetic methodology in OBC
Communication

Palladium-catalyzed salt-free double decarboxylative aryl allylation

We describe a palladium catalyzed salt-free decarboxylative aryl allylation of free benzoic acids with allyl tert-butyl-carbonates.

Graphical abstract: Palladium-catalyzed salt-free double decarboxylative aryl allylation
From the themed collection: New Talent
Communication

Synthesis of hydrophobic insulin-based peptides using a helping hand strategy

A universal “helping hand” to facilitate the synthesis of A chain of insulin-related peptides.

Graphical abstract: Synthesis of hydrophobic insulin-based peptides using a helping hand strategy
From the themed collection: New Talent
Open Access Communication

Total synthesis of incargranine A

Synthetic studies into the origins of the alkaloid incargranine A have resulted in the development of a four-step (longest linear sequence) total synthesis.

Graphical abstract: Total synthesis of incargranine A
From the themed collection: Total synthesis in OBC
Paper

Transition state analysis of an enantioselective Michael addition by a bifunctional thiourea organocatalyst

Transition structure for the bifunctional thiourea catalyzed Michael addition using 13C KIEs and DFT calculations.

Graphical abstract: Transition state analysis of an enantioselective Michael addition by a bifunctional thiourea organocatalyst
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor

19F NMR-guided development of a BPTF chemical probe through SAR and ligand deconstruction.

Graphical abstract: Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor
From the themed collection: Chemical Biology in OBC
Paper

Hydroaminoalkylation of sterically hindered alkenes with N,N-dimethyl anilines using a scandium catalyst

Atom-economical and regioselective C(sp3)–C(sp3) bond formation has been achieved by C(sp3)–H alkylation of N,N-dimethyl anilines with sterically demanding alkenes by scandium catalysis.

Graphical abstract: Hydroaminoalkylation of sterically hindered alkenes with N,N-dimethyl anilines using a scandium catalyst
From the themed collection: Synthetic methodology in OBC
Paper

One-pot stapling of interchain disulfides of antibodies using an isobutylene motif

Stable monoclonal antibodies are generated by the mild and efficient re-bridging of interchain disulfides using an isobutylene motif. Effector functions and pharmacokinetics of the stapled antibodies are maintained at a similar level as their native forms.

Graphical abstract: One-pot stapling of interchain disulfides of antibodies using an isobutylene motif
From the themed collection: Chemical Biology in OBC
Paper

Methyl 5-MeO-N-aminoanthranilate, a minimalist fluorogenic probe for sensing cellular aldehydic load

A minimalist fluorogenic probe is presented capable of the mapping of aldehydic load through live cell microscopy.

Graphical abstract: Methyl 5-MeO-N-aminoanthranilate, a minimalist fluorogenic probe for sensing cellular aldehydic load
From the themed collection: New Talent
Paper

Protic additives or impurities promote imine reduction with pinacolborane

We report here that addition of stoichiometric amounts of alcohols or water to mixtures of imines and pinacolborane promote reduction reactions.

Graphical abstract: Protic additives or impurities promote imine reduction with pinacolborane
From the themed collection: New Talent
Paper

Investigations into the DNA-binding mode of doxorubicinone

Spectroscopic and calorimetric study of DNA-binding by doxorubicin and doxorubicinone found different binding modes for the two molecules, despite their structural homology.

Graphical abstract: Investigations into the DNA-binding mode of doxorubicinone
Paper

Self-assembled micro-fibres by oxime connection of linear peptide amphiphiles

The oxime connection between linear peptides and hydrophobic aldehydes affords amphiphiles that are excellent biocompatible scaffolds for the hierarchical self-assembly of nano and micro fibrillar structures in aqueous media.

Graphical abstract: Self-assembled micro-fibres by oxime connection of linear peptide amphiphiles
From the themed collection: Chemical Biology in OBC
Paper

A hemithioindigo molecular motor for metal surface attachment

We report on the synthesis of a hemithioindigo molecular motor bearing thioether feet for metal surface attachment and a comprehensive study of its light induced unidirectional motion in solution.

Graphical abstract: A hemithioindigo molecular motor for metal surface attachment
Paper

Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent

Thioformamides are easily prepared – under full chemocontrol – through the partial reduction of isothiocyanates with the in situ generated Schwartz reagent.

Graphical abstract: Chemoselective reduction of isothiocyanates to thioformamides mediated by the Schwartz reagent
From the themed collection: Synthetic methodology in OBC
Paper

Synthesis and initial biological evaluation of myxocoumarin B

The first total synthesis of myxocoumarin B along with its initial biological evaluation in antifungal and cytotoxicity assays are reported.

Graphical abstract: Synthesis and initial biological evaluation of myxocoumarin B
From the themed collection: Total synthesis in OBC
Paper

Efficiency and fidelity of T3 DNA ligase in ligase-catalysed oligonucleotide polymerisations

T3 and T4 DNA ligase have contrasting performance in ligase-catalysed oligonucleotide polymerisations.

Graphical abstract: Efficiency and fidelity of T3 DNA ligase in ligase-catalysed oligonucleotide polymerisations
From the themed collection: Chemical Biology in OBC
Paper

Metal-free photocatalytic thiol–ene/thiol–yne reactions

We report a metal-free photocatalytic approach to the synthesis of glycoconjugates, highlighting the mild nature of the reaction conditions.

Graphical abstract: Metal-free photocatalytic thiol–ene/thiol–yne reactions
From the themed collection: Synthetic methodology in OBC
Paper

Reversibly photoswitchable alkoxy azobenzenes connected benzenetricarboxamide discotic liquid crystals with perpetual long range columnar assembly

Reversibly photoswitchable discotic liquid crystals (DLCs) with no change in columnar assembly.

Graphical abstract: Reversibly photoswitchable alkoxy azobenzenes connected benzenetricarboxamide discotic liquid crystals with perpetual long range columnar assembly
From the themed collection: New Talent
Paper

Sulfur polymer composites as controlled-release fertilisers

A controlled-release fertiliser was prepared by the inverse vulcanisation of canola oil in the presence of nitrogen, phosphorous and potassium nutrients.

Graphical abstract: Sulfur polymer composites as controlled-release fertilisers
From the themed collection: New Talent
Paper

Rh-Catalyzed diastereoselective desymmetrization of enone tethered-cyclohexadienones via tandem arylative cyclization

The rhodium-catalyzed arylative cyclization of enone tethered-cyclohexadienones has been developed with high efficiency, thus providing cis-fused bicyclic enones in good yields and with excellent diastereoselectivities.

Graphical abstract: Rh-Catalyzed diastereoselective desymmetrization of enone tethered-cyclohexadienones via tandem arylative cyclization
From the themed collection: Synthetic methodology in OBC
Paper

Understanding the axial chirality control of quinidine-derived ammonium cation-directed O-alkylation: a computational study

DFT calculations reveal the origins of axial chirality control by cinchona alkaloid derivatives.

Graphical abstract: Understanding the axial chirality control of quinidine-derived ammonium cation-directed O-alkylation: a computational study
Paper

Regiospecific formal [3 + 2] annulation of tert-propargyl alcohols with acyclic 1,3-diketones via the cycloisomerization of homoallenyl ketones

A one-pot, regiospecific synthesis of dihydrofurans bearing a quaternary centre is developed from the formal [3 + 2] annulation of tert-propargyl alcohols and 1,3-diketones through the SN2I mechanism to form homoallenyl ketone and a subsequent cycloisomerization reaction.

Graphical abstract: Regiospecific formal [3 + 2] annulation of tert-propargyl alcohols with acyclic 1,3-diketones via the cycloisomerization of homoallenyl ketones
From the themed collection: Synthetic methodology in OBC
Paper

A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede

Structural modulation of the fluorescent protein (FP) chromophore to enable fluorogenic probe for SNAP-tag towards wash-free live cell imaging.

Graphical abstract: A SNAP-tag fluorogenic probe mimicking the chromophore of the red fluorescent protein Kaede
From the themed collection: Chemical Biology in OBC
Paper

Boronic acid-catalysed C-3 selective ring opening of 3,4-epoxy alcohols with thiophenols and thiols

A boronic acid-catalysed C-3 selective ring opening of 3,4-epoxy alcohols with thiophenols and thiols as nucleophiles has been accomplished.

Graphical abstract: Boronic acid-catalysed C-3 selective ring opening of 3,4-epoxy alcohols with thiophenols and thiols
From the themed collection: Catalysis & biocatalysis in OBC
Paper

Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus

Human milk oligosaccharides (HMOs) possess antimicrobial activity against a number of bacterial pathogens.

Graphical abstract: Sialylated variants of lacto-N-tetraose exhibit antimicrobial activity against Group B Streptococcus
From the themed collection: Chemical Biology in OBC
Paper

Enantioselective syntheses and application of 4-epi-galiellalactone and the corresponding activity-based probe: from strained bicycles to strained tricycles

Efficient syntheses of 4-epi-galiellalactone and the corresponding activity-based probe enabled chemoproteomic studies to reveal the biological targets.

Graphical abstract: Enantioselective syntheses and application of 4-epi-galiellalactone and the corresponding activity-based probe: from strained bicycles to strained tricycles
From the themed collection: Chemical Biology in OBC
Paper

Why do A·T and G·C self-sort? Hückel aromaticity as a driving force for electronic complementarity in base pairing

Computations reveal that the potential for aromaticity gain and loss in nucleobases play key roles in modulating base pairing strengths.

Graphical abstract: Why do A·T and G·C self-sort? Hückel aromaticity as a driving force for electronic complementarity in base pairing
Paper

Design, synthesis, and biological evaluation of C7-functionalized DMXAA derivatives as potential human-STING agonists

A strategy to diversely functionalize the C7-position of DMXAA has been developed as a means to discover potential human-STING agonists.

Graphical abstract: Design, synthesis, and biological evaluation of C7-functionalized DMXAA derivatives as potential human-STING agonists
From the themed collection: Chemical Biology in OBC
Paper

A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells

Peroxynitrite (ONOO) is involved in a variety of physiological and pathological processes.

Graphical abstract: A fast-response and highly specific Si-Rhodamine probe for endogenous peroxynitrite detection in living cells
From the themed collection: New Talent
Open Access Paper

Studies on a landscape of perfluoroaromatic-reactive peptides

Diverse peptide sequences and folds promote cysteine arylation.

Graphical abstract: Studies on a landscape of perfluoroaromatic-reactive peptides
From the themed collection: New Talent
Paper

An elusive thermal [2 + 2] cycloaddition driven by visible light photocatalysis: tapping into strain to access C2-symmetric tricyclic rings

A mild and operationally simple methodology is reported for the synthesis of cyclobutane rings imbedded within a C2-symmetric tricyclic framework.

Graphical abstract: An elusive thermal [2 + 2] cycloaddition driven by visible light photocatalysis: tapping into strain to access C2-symmetric tricyclic rings
From the themed collection: New Talent
69 items

About this collection

This issue aims to highlight the excellent work being carried out by newer members of the research community.
It will cover topics including organic synthesis, physical organic chemistry, supramolecular chemistry and chemical biology, and showcase the strength of research being carried out by tomorrow's leaders in the field.
Articles in this themed issue will be added below as soon as possible after they are published. Please return to this page frequently to see the collection grow.

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