Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

Tian Qin; Quanbin Jiang; Jieying Ji; Jie Luo; Xiaodan Zhao

doi:10.1039/C8OB02575D

Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

Tian Qin,^a Quanbin Jiang,^a Jieying Ji,^a Jie Luo^a and Xiaodan Zhao*^a

Author affiliations

* Corresponding authors

^a Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China
E-mail: zhaoxd3@mail.sysu.edu.cn

Abstract

Chiral selenide-catalyzed enantioselective trifluoromethylthiolation of 1,1-disubstituted alkenes is disclosed. By this method, a variety of chiral trifluoromethylthiolated 2,5-disubstituted oxazolines were obtained in good yields with high enantioselectivities. This work not only provides a new pathway for the synthesis of chiral oxazolines, but also expands the library of chiral trifluoromethylthiolated molecules.

This article is part of the themed collections: New Talent and Synthetic methodology in OBC

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Publication details

The article was received on 17 Oct 2018, accepted on 05 Nov 2018 and first published on 05 Nov 2018

Article type: Communication

DOI: 10.1039/C8OB02575D

Citation: Org. Biomol. Chem., 2019,17, 1763-1766

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Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

T. Qin, Q. Jiang, J. Ji, J. Luo and X. Zhao, Org. Biomol. Chem., 2019, 17, 1763
DOI: 10.1039/C8OB02575D
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Organic & Biomolecular Chemistry

Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

Abstract

Supplementary files

Publication details

Chiral selenide-catalyzed enantioselective synthesis of trifluoromethylthiolated 2,5-disubstituted oxazolines

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