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Issue 7, 2019
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ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

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Abstract

We report a high-affinity photoswitchable DNA binder, which displays different nucleosome-binding capacities upon visible-light irradiation. Both photochemical and DNA-recognition properties were examined by UV-Vis, HPLC, CD spectroscopy, NMR, FID assays, EMSA and DLS. Our probe sets the basis for developing new optoepigenetic tools for conditional modulation of nucleosomal DNA accessibility.

Graphical abstract: ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

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Publication details

The article was received on 20 Sep 2018, accepted on 19 Dec 2018 and first published on 21 Dec 2018


Article type: Communication
DOI: 10.1039/C8OB02343C
Citation: Org. Biomol. Chem., 2019,17, 1827-1833

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    ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light

    B. Heinrich, K. Bouazoune, M. Wojcik, U. Bakowsky and O. Vázquez, Org. Biomol. Chem., 2019, 17, 1827
    DOI: 10.1039/C8OB02343C

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