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Themed collection Natural Products

19 items
Review Article

Is it time for artificial intelligence to predict the function of natural products based on 2D-structure

One of chemistry's grand challenges is to find a function for every known metabolite. We explore the opportunity for artificial intelligence to provide rationale interrogation of metabolites to predict their function.

Graphical abstract: Is it time for artificial intelligence to predict the function of natural products based on 2D-structure
From the themed collection: Natural Products
Review Article

Diversification of polyketide structures via synthase engineering

We present examples of polyketide structure diversification along with a perspective on the present and future of polyketide synthetic biology.

Graphical abstract: Diversification of polyketide structures via synthase engineering
From the themed collection: Natural Products
Review Article

Leveraging synthetic biology for producing bioactive polyketides and non-ribosomal peptides in bacterial heterologous hosts

A review discussing the role of heterologous expression in the discovery and engineered production of bioactive polyketides and non-ribosomal peptides from bacteria.

Graphical abstract: Leveraging synthetic biology for producing bioactive polyketides and non-ribosomal peptides in bacterial heterologous hosts
From the themed collection: Natural Products
Review Article

Using Drosophila as a platform for drug discovery from natural products in Parkinson's disease

The review provides an overview of discovery of new drug leads from natural extracts using Drosophila as a screening platform to evaluate the therapeutic potential of phytochemicals against Parkinson's disease.

Graphical abstract: Using Drosophila as a platform for drug discovery from natural products in Parkinson's disease
From the themed collection: Natural Products
Review Article

3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis

KAS III-like enzymes play a significant role in natural product biosynthesis through C–C, C–O, and/or C–N bond formation.

Graphical abstract: 3-Ketoacyl-ACP synthase (KAS) III homologues and their roles in natural product biosynthesis
From the themed collection: Natural Products
Review Article

Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018)

This review covers advances made in genome mining SMs produced by Aspergillus nidulans, Aspergillus fumigatus, Aspergillus niger, and Aspergillus terreus in the past six years (2012–2018). Genetic identification and molecular characterization of SM biosynthetic gene clusters, along with proposed biosynthetic pathways, is discussed in depth.

Graphical abstract: Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018)
From the themed collection: Natural Products
Open Access Research Article

Synthesis of N-acyl amide natural products using a versatile adenylating biocatalyst

TamA is the enzyme that controls the acyl chain length of the tambjamine natural products. Here we show that the catalytic ANL domain of TamA can be used to prepare a range of N-acyl amides.

Graphical abstract: Synthesis of N-acyl amide natural products using a versatile adenylating biocatalyst
From the themed collection: Natural Products
Accepted Manuscript - Research Article

The Winding Road of the Uvaretin Class of Natural Products: From Total Synthesis to Bioactive Agent Discovery.

From the themed collection: Natural Products
Research Article

Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold

Prenylation of aromatic compounds is a key tailoring reaction in biosynthesis of bioactive indole-diterpenes.

Graphical abstract: Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold
From the themed collection: Natural Products
Research Article

Fungal natural alkaloid schizocommunin activates the aryl hydrocarbon receptor pathway

Activation of AhR by schizocommunin is linked to increased expression of xenobiotic metabolizing enzymes associated with immune and allergic responses.

Graphical abstract: Fungal natural alkaloid schizocommunin activates the aryl hydrocarbon receptor pathway
From the themed collection: Natural Products
Research Article

Synthesis, conformational preferences, and biological activity of conformational analogues of the microtubule-stabilizing agents, (−)-zampanolide and (−)-dactylolide

Zampanolide and dactylolide are microtubule-stabilizing polyketides possessing potent cytotoxicity towards a variety of cancer cell lines.

Graphical abstract: Synthesis, conformational preferences, and biological activity of conformational analogues of the microtubule-stabilizing agents, (−)-zampanolide and (−)-dactylolide
From the themed collection: Natural Products
Research Article

How mithramycin stereochemistry dictates its structure and DNA binding function

The crystal structures of mithramycin and its analogue reveal how the chemistry of mithramycin shapes it for DNA binding.

Graphical abstract: How mithramycin stereochemistry dictates its structure and DNA binding function
From the themed collection: Natural Products
Research Article

Volatiles from the ascomycete Daldinia cf. childiae (Hypoxylaceae), originating from China

The volatiles from an isolate of the fungus Daldinia cf. childiae, obtained from a specimen collected in China, were collected by use of a closed-loop stripping apparatus and analysed by GC-MS.

Graphical abstract: Volatiles from the ascomycete Daldinia cf. childiae (Hypoxylaceae), originating from China
From the themed collection: Natural Products
Research Article

Synthesis of endolides A and B: naturally occurring N-methylated cyclic tetrapeptides

The first syntheses of the bioactive cyclic tetrapeptide natural products, endolides A and B, were accomplished using a solution-phase macrocyclisation reaction; the stereoselectivity of which was found to be reagent-controlled.

Graphical abstract: Synthesis of endolides A and B: naturally occurring N-methylated cyclic tetrapeptides
From the themed collection: Natural Products
Research Article

Construction of a hybrid gene cluster to reveal coupled ring formation–hydroxylation in the biosynthesis of HSAF and analogues from Lysobacter enzymogenes

HSAF and analogues are polycyclic tetramate macrolactams (PoTeMs) isolated from Lysobacter enzymogenes.

Graphical abstract: Construction of a hybrid gene cluster to reveal coupled ring formation–hydroxylation in the biosynthesis of HSAF and analogues from Lysobacter enzymogenes
From the themed collection: Natural Products
Accepted Manuscript - Research Article

Synthesis and Direct Comparison of the Anticancer Activities of Phomopsolides D/E and Two 7-Oxa-/7-Aza-analogues

From the themed collection: Natural Products
Research Article

Stereoselective semi-synthesis of the neuroprotective natural product, serofendic acid

Our synthesis of neuroprotectant serofendic acid from biosourced ent-atis-16-en-19-oic acid represents the best route to date.

Graphical abstract: Stereoselective semi-synthesis of the neuroprotective natural product, serofendic acid
From the themed collection: Natural Products
Research Article

Origin and bioactivities of thiosulfinated FK228

During a large laboratory-scale purification of FK228 from the fermentation broth of Burkholderia thailandensis MSMB43, a small amount of thiosulfinated FK228 (TS-FK228) was unexpectedly purified only after the broth was mixed with silica gel.

Graphical abstract: Origin and bioactivities of thiosulfinated FK228
From the themed collection: Natural Products
Research Article

Isolation and characterization of tambjamine MYP1, a macrocyclic tambjamine analogue from marine bacterium Pseudoalteromonas citrea

Identification of a macrocyclic tambjamine natural product, tambjamine MYP1, from a marine bacterium that may enhance bioactivity by restraining bond rotation.

Graphical abstract: Isolation and characterization of tambjamine MYP1, a macrocyclic tambjamine analogue from marine bacterium Pseudoalteromonas citrea
From the themed collection: Natural Products
19 items

About this collection

This themed collection, Guest Edited by Professor Sylvie Garneau-Tsodikova, highlights the latest advances in natural product chemistry, including discovery, biosynthesis, pathway engineering, and natural product synthesis.
Articles in this themed collection will be added below as soon as possible after they are published.
Please return to this page frequently to see the collection grow.

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