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Synthesis and Direct Comparison of the Anticancer Activities of Phomopsolides D/E and Two 7-Oxa-/7-Aza-analogues

Abstract

The synthesis of two stable phomopsolide natural products (D and E) and two analogues are presented. The cytotoxicity of these four compounds is surveyed and compared across a panel of NCI-cancer cell lines. This analysis found moderate cytotoxicities (2-50 microM) for the majority of the cell lines with phomopsolide D being more active than phomopsolide E and the 7-oxa analogue being commensurately more active than the 7-aza analogue.

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Publication details

The article was received on 28 Feb 2019, accepted on 29 Apr 2019 and first published on 08 May 2019


Article type: Research Article
DOI: 10.1039/C9MD00121B
Med. Chem. Commun., 2019, Accepted Manuscript

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    Synthesis and Direct Comparison of the Anticancer Activities of Phomopsolides D/E and Two 7-Oxa-/7-Aza-analogues

    A. Z. Aljahdali, S. Freedman, J. Scott, M. Li and G. A. O'Doherty, Med. Chem. Commun., 2019, Accepted Manuscript , DOI: 10.1039/C9MD00121B

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