Synthesis and Direct Comparison of the Anticancer Activities of Phomopsolides D/E and Two 7-Oxa-/7-Aza-analogues
The synthesis of two stable phomopsolide natural products (D and E) and two analogues are presented. The cytotoxicity of these four compounds is surveyed and compared across a panel of NCI-cancer cell lines. This analysis found moderate cytotoxicities (2-50 microM) for the majority of the cell lines with phomopsolide D being more active than phomopsolide E and the 7-oxa analogue being commensurately more active than the 7-aza analogue.
- This article is part of the themed collection: Natural Products