Jump to main content
Jump to site search

Issue 7, 2019
Previous Article Next Article

Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold

Author affiliations

Abstract

Prenylation of aromatic compounds is a key tailoring reaction in biosynthesis of bioactive indole-diterpenes. Here, we identify NodD1 as the enzyme responsible for the bisprenylation of nodulisporic acid F. This prenyltransferase showed a preference for its natural indole-diterpene substrate whereas other related enzymes were not able to catalyse this conversion.

Graphical abstract: Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold

Back to tab navigation

Supplementary files

Article information


Submitted
08 Mar 2019
Accepted
22 May 2019
First published
27 May 2019

Med. Chem. Commun., 2019,10, 1160-1164
Article type
Research Article

Nodulisporic acid E biosynthesis: in vivo characterisation of NodD1, an indole-diterpene prenyltransferase that acts on an emindole SB derived indole-diterpene scaffold

K. C. Van de Bittner, R. C. Cameron, L. Y. Bustamante, R. Bundela, S. A. Kessans, J. Vorster, M. J. Nicholson and E. J. Parker, Med. Chem. Commun., 2019, 10, 1160
DOI: 10.1039/C9MD00143C

Search articles by author

Spotlight

Advertisements