Microfluidic technologies for vasculature biomimicry
An overview of microfluidic technologies for vascular studies and fabrication of vascular structures.
Recent advances in reaction-based fluorescent probes for detecting monoamine oxidases in living systems
This Minireview summarizes the recent advances in reaction based MAO type fluorescent probes and their imaging applications in living systems.
Single cell transcriptomics: moving towards multi-omics
Single-cell multi-omics analysis helps characterize multiple layers of molecular features at a single-cell scale to provide insights into cellular processes and functions.
Recent advances in and potential utilities of paper-based electrochemical sensors: beyond qualitative analysis
Paper based electrochemical sensors (PESs) are simple, low-cost, portable and disposable analytical sensing platforms that can be applied in clinical diagnostics, food quality control and environmental monitoring.
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Multiplex lateral flow immunoassays for outstanding POCT of infectious diseases.
Advances in diagnostic methods for keloids and biomarker-targeted fluorescent probes
A focused review of keloid diagnosis, keloid biomarkers, and recently reported fluorescent probes.
Emerging trends in sensors based on carbon nitride materials
A new class of functional materials, carbon nitrides, has recently attracted the attention of researchers.
New mass spectrometry technologies contributing towards comprehensive and high throughput omics analyses of single cells
We provide a vision for integrating pioneering mass spectrometry technologies for future applications in single cell analysis.
Advances in mass spectrometry based single-cell metabolomics
Single cell metabolomics using mass spectrometry can contribute to understanding biological activities in health and disease.
Quantitative imaging of lipid droplets in single cells
Non-destructive spatial characterization of lipid droplets using coherent Raman scattering microscopy and computational image analysis algorithms at the single-cell level.
Analysing single live cells by scanning electrochemical microscopy
Scanning electrochemical microscopy (SECM) offers single live cell activities along its topography toward cellular physiology and pathology.
Recent advances in single cell manipulation and biochemical analysis on microfluidics
This review highlights the advances in single cell manipulation and biochemical analysis on microfluidics over the past three years.
Advancements in fractal plasmonics: structures, optical properties, and applications
Fractal nanostructures exhibit optical properties that span the visible to far-infrared and are emerging as exciting structures for plasmon-mediated applications.
Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease
Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer.
Synthesis, design and sensing applications of nanostructured ceria-based materials
Cerium-based materials possess redox properties due to the presence of dual valence states of Ce3+ and Ce4+.
Investigations on the interface of nucleic acid aptamers and binding targets
The binding targets of aptamers, the interaction probing methods, and the main binding forces mediating the interaction have been summarized.
Lipid metabolism in inflammation-related diseases
Lipidomics is used to describe the complete lipid profile and network of cellular lipid metabolism. Traditionally, lipids are recognized as general membrane construction and energy storage molecules. Now, lipids are regarded as potent signaling molecules that regulate a multitude of cellular responses.
Luminescent switch sensors for the detection of biomolecules based on metal–organic frameworks
The applications of MOFs-based luminescent sensors for biomolecules sensing via a “turn on” or “turn off” response have been reviewed.
Direct label-free imaging of brain tissue using synchrotron light: a review of new spectroscopic tools for the modern neuroscientist
A suite of direct spectroscopic imaging techniques using synchrotron light can provide increased biochemical insight into brain disease.
Chemical clocks, oscillations, and other temporal effects in analytical chemistry: oddity or viable approach?
We review chemo-chronometric assays, in which the time factor—rather than analogue signals—is used to determine concentrations of analytes.
Platforms for rapid cancer characterization by ambient mass spectrometry: advancements, challenges and opportunities for improvement towards intrasurgical use
Ambient Mass Spectrometry (MS) analysis is widely used to characterize biological and non-biological samples.
Recent advances in merging photonic crystals and plasmonics for bioanalytical applications
The integration of photonic crystals and plasmonics enhances the performance of bioanalytical applications.
How iMALDI can improve clinical diagnostics
Protein mass spectrometry (MS) is an indispensable tool to detect molecular signatures that can be associated with cellular dysregulation and disease.
Biosensing strategies based on enzymatic reactions and nanoparticles
Application of new nanomaterials to detection of enzymatic activities allows the development of new sensitive and selective bioanalytical assays based on enzymes for recognition and signal amplification.
Mobile diagnostics: next-generation technologies for in vitro diagnostics
The emergence of a wide range of applications of smartphones along with advances in ‘liquid biopsy’ has significantly propelled medical research particularly in the field of in vitro diagnostics (IVD).
Gas-generating reactions for point-of-care testing
Gas generation-based measurement is an attractive alternative approach for POC (Point-of-care) testing, which relies on the amount of generated gas to detect the corresponding target concentrations.
Chem/bio sensing with non-classical light and integrated photonics
Modern quantum technology experiences currently extensive advances in its applicability in communications, cryptography, computing, metrology and lithography. Harnessing this technology platform for chem/bio sensing scenarios is an appealing possibility to enable ultra-sensitive detection schemes.
Sample preparation for polar metabolites in bioanalysis
Sample preparation is a primary step of any bioanalytical workflow, especially in metabolomics where maximum information has to be obtained without spoiling the analytical instrument. The sample extraction of polar metabolites is still challenging but strategies exist to enable the phase transfer of hydrophilic metabolites from the biological phase to a clean interference-free phase.
True one cell chemical analysis: a review
The constantly growing field of True One Cell (TOC) analysis has provided important information on the direct chemical composition of various cells and cellular components.
Measuring and regulating oxygen levels in microphysiological systems: design, material, and sensor considerations
Quantifying and regulating oxygen in a microphysiological models can be achieved via an array of technologies, and is an essential component of recapitulating tissue-specific microenvironments.
Fluorescent organic nanoparticles (FONs) as convenient probes for metal ion detection in aqueous medium
Fluorescent organic nanoparticle (FON)-based chemosensors are emerging as a valuable tool for the fast and accurate detection of metal ions in aqueous media. In this review, we highlight the recent developments in this field.
A unified approach for investigating chemosensor properties – dynamic characteristics
The response is what makes a sensor. In this review the methods for characterizing the response are laid out.
A pressure-driven gas-diffusion/permeation micropump for self-activated sample transport in an extreme micro-environment
The pressure-driven gas-diffusion/permeation micropump is highlighted for stable microdroplet/liquid delivery under extreme conditions, e.g. high temperature, and a three-dimensional, long-distance and complex-topology microchannel.
Single-system based discriminative optical sensors: different strategies and versatile applications
Single-system based optical sensors can realize discrimination through multi-wavelength cross-reactive responses by different strategies.
Advances in the integration of quantum dots with various nanomaterials for biomedical and environmental applications
We review the advances in the integration of quantum dots with various nanomaterials for biomedical and environmental applications.
Advances in point-of-care diagnostic devices in cancers
The early diagnosis and monitoring of the progress of cancers are limited due to the lack of adequate screening tools.
Chemical analysis in saliva and the search for salivary biomarkers – a tutorial review
A review of the uses of saliva biomarkers, detection methods and requirements for new biomarkers.
Insulin: a review of analytical methods
Insulin is an important polypeptide hormone that regulates carbohydrate metabolism.
Novel approaches for biomolecule immobilization in microscale systems
This manuscript reviews novel approaches applied for biomolecule immobilization in microscale systems.
Recent advances in open tubular capillary liquid chromatography
This review covers advances and applications of open tubular capillary liquid chromatography (OT-LC) over the period 2007–2018.
Recent advances in nanomaterial-based electrochemical and optical sensing platforms for microRNA assays
This review describes recent efforts in the application of nanomaterials as sensing elements in electrochemical and optical miRNAs assays.
Click chemistry at the microscale
This manuscript reviews recent developments in click chemistry in microscale systems.
Gold nanoparticle based fluorescent oligonucleotide probes for imaging and therapy in living systems
Gold nanoparticles (AuNPs) with unique physical and chemical properties have become an integral part of research in nanoscience.
Direct sampling mass spectrometry for clinical analysis
Direct sampling mass spectrometry enables high-performance clinical analysis, such as imaging, drug monitoring and point-of-care testing.
High throughput screening of complex biological samples with mass spectrometry – from bulk measurements to single cell analysis
We review the state of the art in HTS using mass spectrometry with minimal sample preparation from complex biological matrices. We focus on industrial and biotechnological applications.
Molecular and living cell dynamic assays with optical microscopy imaging techniques
Compared with the conventional ensemble averaged measurements, single object analysis with optical microscopy can obtain the heterogeneous behavior of many individual objects, avoiding false judgment. Moreover, higher spatial and temporal resolution has been achieved by various optical imaging technologies.
Recent advances in single-cell analysis by mass spectrometry
Cells are the most basic structural units that play vital roles in the functioning of living organisms.
Advancing single-cell proteomics and metabolomics with microfluidic technologies
Recent advances in single-cell analysis have unraveled substantial heterogeneity among seemingly identical cells at genomic and transcriptomic levels.
Single-cell assay on microfluidic devices
Advances in microfluidic techniques have prompted researchers to study the inherent heterogeneity of single cells in cell populations.
Zeolites and zeolite-based materials in extraction and microextraction techniques
This review presents an overview of the current status of zeolites and zeolite-based materials used in extraction and microextraction techniques with reference to recent applications and highlight some of the novel advances.
Nanomaterials for luminescent detection of water and humidity
Significant advances of typical nanomaterials in the luminescent detection of water and humidity are presented.
A review of methods for the detection of pathogenic microorganisms
The testing and rapid detection of pathogenic organisms is a crucial protocol in the prevention and identification of crises related to health, safety and wellbeing.
Review: a comprehensive summary of a decade development of the recombinase polymerase amplification
RPA is a versatile complement or replacement of PCR, and now is stepping into practice.
Molecular methods in electrochemical microRNA detection
High-throughput profiling/sensing of nucleic acids has recently emerged as a highly promising strategy for the early diagnosis and improved prognosis of a broad range of pathologies, most notably cancer. The review highlights some of the most promising strategies for electrochemical sensing of microRNA biomarkers.
A review of sorting, separation and isolation of cells and microbeads for biomedical applications: microfluidic approaches
We have reviewed the microfluidic approaches for cell/particle isolation and sorting, and extensively explained the mechanism behind each method.
Microfluidic bioanalytical flow cells for biofilm studies: a review
A comprehensive review of the current state of microfluidic bioanalytical research applied to bacterial biofilms.
Biomedical applications of mid-infrared quantum cascade lasers – a review
Quantum cascade lasers with high spectral power density and narrow band emission profiles provide novel access to biomedical applications.
Graphene, electrospun membranes and granular activated carbon for eliminating heavy metals, pesticides and bacteria in water and wastewater treatment processes
The availability of safe water has a significant impact on all parts of society, its growth and sustainability, both politically and socioeconomically.
Exploring the potential of electroless and electroplated noble metal–semiconductor hybrids within bio- and environmental sensing
This manuscript provides an elaborate review on galvanic noble metal nanoparticles deposited onto semiconductor surfaces, from the preparation stage towards their application in biosensors and gas sensing.
Smartphone-based analytical biosensors
With the rapid development, mass production, and pervasive distribution of smartphones in recent years, they have provided people with portable, cost-effective, and easy-to-operate platforms to build analytical biosensors for point-of-care (POC) applications and mobile health.
Graphene-based nanoplatforms for surface-enhanced Raman scattering sensing
We demonstrate recent advances in the fabrication and SERS sensing applications of graphene-based nanoplatforms.
DNA methylation detection: recent developments in bisulfite free electrochemical and optical approaches
The recent development of optical and electrochemical biosensors for bisulfite treatment free DNA methylation detection methods have been reviewed. The major challenges associated with the bisulfite treatment in DNA methylation detection and their potential solutions are also discussed.
Nanomaterial based electrochemical sensors for the safety and quality control of food and beverages
Electrochemical determination of some common additives and contaminants, which are widely found in food and beverages.
Electrochemical microfluidics techniques for heavy metal ion detection
Heavy metals refer to metals with a density above 5 × 103 kg m−3, such as lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg).
Advances in surface-enhanced Raman spectroscopy (SERS) substrates for lipid and protein characterization: sensing and beyond
Developments in SERS substrates are enabling detection and biophysical characterization of lipids, protein and cellular systems with improved sensitivity, reproducibility and biocompatibility.
Molecularly imprinted polymers’ application in pesticide residue detection
Molecularly imprinted polymers (MIPs) are produced using molecular imprinting technology (MIT) and have specific analyte-binding abilities and unique properties, including chemical and thermal stability, reusability, high selectivity, and high sensitivity.
Partial least squares-discriminant analysis (PLS-DA) for classification of high-dimensional (HD) data: a review of contemporary practice strategies and knowledge gaps
This review highlights and discusses critically various knowledge gaps in classification modelling using PLS-DA for high dimensional data.
Optical assays based on colloidal inorganic nanoparticles
Colloidal inorganic nanoparticles have wide applications in the detection of analytes and in biological assays.
Electrochemiluminescence biosensing based on different modes of switching signals
Electrochemiluminescence (ECL) has attracted much attention in various fields of analysis owing to low background signals, high sensitivity, and excellent controllability.
Advancements in microfluidic technologies for isolation and early detection of circulating cancer-related biomarkers
Isolation of circulating biomarkers using microfluidic devices for cancer diagnosis.
About this collection
This themed collection features recent review articles published in Analyst.