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Issue 16, 2019
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True one cell chemical analysis: a review

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The constantly growing field of True One Cell (TOC) analysis has provided important information on the direct chemical composition of various cells and cellular components. Since the heterogeneity of individual cells has been established, more researchers are interested in the chemical differences between individual cells; TOC is the only form of analysis that can provide this information. This has resulted in the constant development of new technologies and methods. This review highlights the common techniques for micro- and nanomanipulation, Raman spectroscopy, microscopy, and mass spectrometric imaging as they pertain to TOC chemical analysis.

Graphical abstract: True one cell chemical analysis: a review

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The article was received on 27 Mar 2019, accepted on 20 May 2019 and first published on 23 May 2019

Article type: Tutorial Review
DOI: 10.1039/C9AN00558G
Analyst, 2019,144, 4733-4749

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    True one cell chemical analysis: a review

    I. W. De Silva, A. R. Kretsch, H. Lewis, M. Bailey and G. F. Verbeck, Analyst, 2019, 144, 4733
    DOI: 10.1039/C9AN00558G

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