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Issue 6, 2018
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Gas-generating reactions for point-of-care testing

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Gas generation-based measurement is an attractive alternative approach for POC (Point-of-care) testing, which relies on the amount of generated gas to detect the corresponding target concentrations. In gas generation-based POC testing, the integration of a target recognition component and a catalyzed gas-generating reaction initiated by the target introduction can lead to greatly amplified signals, which can be highly sensitive measured via distance readout or simple hand-held devices. More importantly, numerous gas-generating reactions are environment-friendly since their products such as oxygen and nitrogen are nontoxic and odourless, which makes gas generation-based POC testing safe and secure for inexperienced staff. Researchers have demonstrated that gas generation-based measurements enable the rapid and highly sensitive POC detection of a variety of analytes. In this review, we focus on the recent developments in gas generation-based POC testing systems. The common types of gas-generating reactions are first listed and the translation of gas signals to different signal readouts for POC testing are then summarized, including distance readouts and hand-held devices. Moreover, we introduce gas bubbles as actuators to power microfluidic devices. We finally provide the applications and future perspective of gas generation-based POC testing systems.

Graphical abstract: Gas-generating reactions for point-of-care testing

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Article information

03 Jan 2018
15 Feb 2018
First published
16 Feb 2018

Analyst, 2018,143, 1294-1304
Article type

Gas-generating reactions for point-of-care testing

D. Liu, T. Tian, X. Chen, Z. Lei, Y. Song, Y. Shi, T. Ji, Z. Zhu, L. Yang and C. Yang, Analyst, 2018, 143, 1294
DOI: 10.1039/C8AN00011E

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