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Themed collection Most popular 2018-2019 analytical chemistry articles

30 items
Open Access Perspective

Fluorescent probes for organelle-targeted bioactive species imaging

The dynamic fluctuations of bioactive species in living cells are associated with numerous physiological and pathological phenomena. The emergence of organelle-targeted fluorescent probes has significantly facilitated our understanding on the biological functions of these species. This review describes the design, applications, challenges and potential directions of organelle-targeted bioactive species probes.

Graphical abstract: Fluorescent probes for organelle-targeted bioactive species imaging
Open Access Minireview

In-depth structural analysis of glycans in the gas phase

Although there have been substantial improvements in glycan analysis over the past decade, the lack of both high-resolution and high-throughput methods hampers progress in glycomics.

Graphical abstract: In-depth structural analysis of glycans in the gas phase
Open Access Minireview

Electrochemical imaging of cells and tissues

This minireview summarizes the recent achievements of electrochemical imaging platforms to map cellular functions in biological specimens using electrochemical scanning nano/micro-probe microscopy and 2D chips containing microelectrode arrays.

Graphical abstract: Electrochemical imaging of cells and tissues
Open Access Minireview

Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging

A review of recent advances in near-infrared II fluorophores for multifunctional biomedical imaging.

Graphical abstract: Recent advances in near-infrared II fluorophores for multifunctional biomedical imaging
Open Access Edge Article

Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+

Two endoplasmic reticulum (ER) targeting probes were developed to image mobile Zn2+ to help understand Zn2+ related biological processes in the ER.

Graphical abstract: Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Edge Article

A “Double-Locked” and enzyme-activated molecular probe for accurate bioimaging and hepatopathy differentiation

A “double-locked” and enzyme-activated molecular fluorescent probe for accurate bioimaging and hepatopathy differentiation.

Graphical abstract: A “Double-Locked” and enzyme-activated molecular probe for accurate bioimaging and hepatopathy differentiation
Open Access Edge Article

Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy

Theranostic nanoprobes (SYL NPs) prepared from a newly designed NIR-II fluorophore and FDA approved DSPE-mPEG5000 were well tolerated and exhibited multifunctional potential in diagnosis (photoacoustic & fluorescence imaging) and phototherapy in animal models.

Graphical abstract: Rational design of a multifunctional molecular dye for dual-modal NIR-II/photoacoustic imaging and photothermal therapy
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Edge Article

Mitochondria-targeting fluorescent molecules for high efficiency cancer growth inhibition and imaging

5BMF is a new fluorescent mitochondria-accumulating delocalized lipophilic cations [DLC] that boasts significantly increased anti-cancer effects and low toxicity in comparison to previous DLCs, addressing current hurdles in DLC clinical translation.

Graphical abstract: Mitochondria-targeting fluorescent molecules for high efficiency cancer growth inhibition and imaging
Open Access Edge Article

A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging

A molecular design strategy is established to access diverse enzyme-activated probes that are excitable and emit in the NIR (I and II) region with favorable Stokes shifts, enabling targeted cancer imaging by real-time monitoring enzyme activities.

Graphical abstract: A molecular design strategy toward enzyme-activated probes with near-infrared I and II fluorescence for targeted cancer imaging
Open Access Edge Article

Diketopyrrolopyrrole-based fluorescence probes for the imaging of lysosomal Zn2+ and identification of prostate cancer in human tissue

Diketopyrrolopyrrole-based fluorescent probes have been developed for the detection of low pH and Zn2+ in an AND logic fashion. They can discriminate between cancerous and healthy prostate tissue.

Graphical abstract: Diketopyrrolopyrrole-based fluorescence probes for the imaging of lysosomal Zn2+ and identification of prostate cancer in human tissue
From the themed collection: 2019 Chemical Science HOT Article Collection
Open Access Edge Article

Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe

Probe C7 for the first time presents different modes of fluorescence signals to both nanomolar and micromolar concentrations of HOCl.

Graphical abstract: Evaluation of HOCl-generating anticancer agents by an ultrasensitive dual-mode fluorescent probe
From the themed collection: The Mechanics of Supramolecular Chemistry
Open Access Edge Article

Telomerase and poly(ADP-ribose) polymerase-1 activity sensing based on the high fluorescence selectivity and sensitivity of TOTO-1 towards G bases in single-stranded DNA and poly(ADP-ribose)

Telomerase and poly(ADP-ribose) polymerase-1 (PARP-1) are two potential cancer biomarkers and are closely related to tumor initiation and malignant progression.

Graphical abstract: Telomerase and poly(ADP-ribose) polymerase-1 activity sensing based on the high fluorescence selectivity and sensitivity of TOTO-1 towards G bases in single-stranded DNA and poly(ADP-ribose)
Open Access Edge Article

Direct sequencing of 2′-deoxy-2′-fluoroarabinonucleic acid (FANA) using nanopore-induced phase-shift sequencing (NIPSS)

The first demonstration of direct sequencing of 2′-deoxy-2′-fluoroarabinonucleic acid (FANA) using Nanopore-Induced Phase-Shift Sequencing (NIPSS).

Graphical abstract: Direct sequencing of 2′-deoxy-2′-fluoroarabinonucleic acid (FANA) using nanopore-induced phase-shift sequencing (NIPSS)
Open Access Edge Article

Collision cross section compendium to annotate and predict multi-omic compound identities

The Unified Compendium is an online interactive tool that utilizes ion mobility collision cross sections to annotate biochemical molecules.

Graphical abstract: Collision cross section compendium to annotate and predict multi-omic compound identities
Open Access Edge Article

An enzyme-activatable probe liberating AIEgens: on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells

We describe an enzyme-regulated liberation strategy to in situ generate AIEgen nanoaggregates for on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells.

Graphical abstract: An enzyme-activatable probe liberating AIEgens: on-site sensing and long-term tracking of β-galactosidase in ovarian cancer cells
Open Access Edge Article

Rational design of a super-contrast NIR-II fluorophore affords high-performance NIR-II molecular imaging guided microsurgery

A super-contrast NIR-II fluorophore IR-BEMC6P with enhanced quantum yield is developed and the excretion mechanism is identified.

Graphical abstract: Rational design of a super-contrast NIR-II fluorophore affords high-performance NIR-II molecular imaging guided microsurgery
Open Access Edge Article

Molecular design of near-infrared fluorescent Pdots for tumor targeting: aggregation-induced emission versus anti-aggregation-caused quenching

This article presents the first work to fundamentally study the effect of steric hindrance in Pdot systems.

Graphical abstract: Molecular design of near-infrared fluorescent Pdots for tumor targeting: aggregation-induced emission versus anti-aggregation-caused quenching
Open Access Edge Article

A long-lived peptide-conjugated iridium(III) complex as a luminescent probe and inhibitor of the cell migration mediator, formyl peptide receptor 2

Formyl peptide receptors play important biological and therapeutic roles in wound repair and inflammatory diseases.

Graphical abstract: A long-lived peptide-conjugated iridium(iii) complex as a luminescent probe and inhibitor of the cell migration mediator, formyl peptide receptor 2
Open Access Edge Article

Combined reversible switching of ECD and quenching of CPL with chiral fluorescent macrocycles

A series of chiral fluorescent macrocycles display a remarkable combination of both +/– ECD and strong on/off CPL reversible switching upon cation binding and displacement.

Graphical abstract: Combined reversible switching of ECD and quenching of CPL with chiral fluorescent macrocycles
Open Access Edge Article

Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis

Development of molecular probes for the detection of reactive oxygen and nitrogen species (RONS) is important for the pathology and diagnosis of keloid diseases.

Graphical abstract: Near-infrared fluorescence probes to detect reactive oxygen species for keloid diagnosis
Open Access Edge Article

Extraordinary water adsorption characteristics of graphene oxide

The laminated structure of graphene oxide (GO) confers unique interactions with water molecules which may be utilised in a range of applications that require materials with tuneable hygroscopic properties.

Graphical abstract: Extraordinary water adsorption characteristics of graphene oxide
Open Access Edge Article

Translating molecular detections into a simple temperature test using a target-responsive smart thermometer

A novel target-responsive smart thermometer for translating molecular detection into a temperature test has been developed.

Graphical abstract: Translating molecular detections into a simple temperature test using a target-responsive smart thermometer
Open Access Edge Article

ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation

Reactive oxygen species (ROS) scavenging Mn3O4 nanozymes effectively protected live mice from ROS-induced ear-inflammation in vivo.

Graphical abstract: ROS scavenging Mn3O4 nanozymes for in vivo anti-inflammation
Open Access Edge Article

Fabrication of microstructured binary polymer brush “corrals” with integral pH sensing for studies of proton transport in model membrane systems

Binary polymer brush microstructures incorporating ratiometric fluorescent pH indicators enable in situ studies of light-activated transmembrane proton transport by proteorhodopsin.

Graphical abstract: Fabrication of microstructured binary polymer brush “corrals” with integral pH sensing for studies of proton transport in model membrane systems
Open Access Edge Article

Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery

The first small-molecule based αvβ3-targeted NIR-II/PET dual-modal probes via base-catalyzed thiol-addition chemistry were concisely assembled and evaluated.

Graphical abstract: Novel dual-function near-infrared II fluorescence and PET probe for tumor delineation and image-guided surgery
Open Access Edge Article

High throughput reaction screening using desorption electrospray ionization mass spectrometry

We report the high throughput analysis of reaction mixture arrays using methods and data handling routines that were originally developed for biological tissue imaging.

Graphical abstract: High throughput reaction screening using desorption electrospray ionization mass spectrometry
Open Access Edge Article

Cell imaging of dopamine receptor using agonist labeling iridium(III) complex

A long-lived complex 13 could selectively bind to dopamine receptors (D1R/D2R) and monitor their internalization in living cells.

Graphical abstract: Cell imaging of dopamine receptor using agonist labeling iridium(iii) complex
Open Access Edge Article

Simultaneous sensitive detection of multiple DNA glycosylases from lung cancer cells at the single-molecule level

We demonstrate the simultaneous detection of human 8-oxoguanine DNA glycosylase 1 and human alkyladenine DNA glycosylase at the single-molecule level.

Graphical abstract: Simultaneous sensitive detection of multiple DNA glycosylases from lung cancer cells at the single-molecule level
Open Access Edge Article

Deformylation reaction-based probe for in vivo imaging of HOCl

We report a near-infrared emissive probe which can detect HOCl in vivo by both fluorescence imaging and the naked eye.

Graphical abstract: Deformylation reaction-based probe for in vivo imaging of HOCl
Open Access Edge Article

Construction of an autonomously concatenated hybridization chain reaction for signal amplification and intracellular imaging

The concatenated hybridization chain reaction (C-HCR) was constructed as a versatile and robust tool for signal amplification and intracellular imaging, which was attributed to the synergistic amplification effect between HCR-1 and HCR-2.

Graphical abstract: Construction of an autonomously concatenated hybridization chain reaction for signal amplification and intracellular imaging
30 items

About this collection

This specially curated collection pulls together some of the most popular articles from 2018 and 2019 in the field of analytical chemistry. The collection presents some outstanding contributions to the field, ranging from high throughput reaction screening using desorption electrospray ionization mass spectrometry to a review of fluorescent probes for organelle-targeted bioactive species imaging, and as with all Chemical Science articles - they are all completely free to access and read. We hope you enjoy browsing through this collection.

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