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Themed collection Pioneering Investigators

36 items
Editorial

Pioneering Investigators 2017

This themed issue of Polymer Chemistry highlights the work of pioneering investigators in the polymer chemistry field. Associate Editors Emily Pentzer and Eva Harth introduce the issue.

Graphical abstract: Pioneering Investigators 2017
From the themed collection: Pioneering Investigators
Minireview

Ring-expansion cationic polymerization of vinyl ethers

Ring-expansion cationic polymerization of vinyl ethers with a hemiacetal ester-embedded cyclic initiator allows precise syntheses of ring-based architectures due to the controlled propagation as well as the monomer pendant design.

Graphical abstract: Ring-expansion cationic polymerization of vinyl ethers
From the themed collection: Pioneering Investigators
Review Article

Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines

Application of 3D multicellular tumor spheroids to the investigation of polymer nanomedicines.

Graphical abstract: Multicellular tumor spheroids: a relevant 3D model for the in vitro preclinical investigation of polymer nanomedicines
From the themed collection: Pioneering Investigators
Review Article

Opportunities for dual RDRP agents in synthesizing novel polymeric materials

Dual RDRP agents provide access to new polymeric materials by combining ATRP, NMP, and RAFT polymerization without end group transformations.

Graphical abstract: Opportunities for dual RDRP agents in synthesizing novel polymeric materials
From the themed collection: Pioneering Investigators
Open Access Communication

Facile thiolation of hydroxyl functional polymers

A simple synthetic pathway to broaden the accessibility of thiol-functional polymers including formation of dendritic hydrogels via TEC chemistry.

Graphical abstract: Facile thiolation of hydroxyl functional polymers
From the themed collection: Pioneering Investigators
Communication

Water-based acrylic coatings reinforced by PISA-derived fibers

Polymerization-induced self-assembly (PISA) provides nanofibers that may be used as reinforcing fillers for all-organic aqueous coatings.

Graphical abstract: Water-based acrylic coatings reinforced by PISA-derived fibers
From the themed collection: Pioneering Investigators
Communication

Sequence-coded ATRP macroinitiators

Sequence-defined oligourethanes were transformed into ATRP initiators and used for the synthesis of precision macromolecular architectures.

Graphical abstract: Sequence-coded ATRP macroinitiators
From the themed collection: Pioneering Investigators
Communication

Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units.

Graphical abstract: Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers
From the themed collection: Pioneering Investigators
Communication

Aqueous RAFT at pH zero: enabling controlled polymerization of unprotected acyl hydrazide methacrylamides

A first example of controlled radical polymerization of monomers containing unprotected acyl hydrazide pendent groups was demonstrated using aqueous RAFT polymerization at pH = 0.

Graphical abstract: Aqueous RAFT at pH zero: enabling controlled polymerization of unprotected acyl hydrazide methacrylamides
From the themed collection: Pioneering Investigators
Paper

Anti-protein and anti-bacterial behavior of amphiphilic silicones

Silicones bulk-modified with various PEO-silane amphiphiles were demonstrated to be resistant to plasma proteins, several bacteria, and a fungus.

Graphical abstract: Anti-protein and anti-bacterial behavior of amphiphilic silicones
From the themed collection: Pioneering Investigators
Paper

Synthesis of molecular brushes by telomerization

This work reports the straightforward synthesis of molecular brushes by telomerization from polythiol multifunctional macrotransfer agents.

Graphical abstract: Synthesis of molecular brushes by telomerization
From the themed collection: Pioneering Investigators
Open Access Paper

Introduction of anti-fouling coatings at the surface of supramolecular elastomeric materials via post-modification of reactive supramolecular additives

A covalent anti-fouling is introduced at the surface of supramolecular ureidopyrimidinone (UPy) based materials to prevent both protein and cell adhesion.

Graphical abstract: Introduction of anti-fouling coatings at the surface of supramolecular elastomeric materials via post-modification of reactive supramolecular additives
From the themed collection: Pioneering Investigators
Paper

Enzyme-targeted nanoparticles for delivery to ischemic skeletal muscle

In this study, we show for the first time enzyme-directed assembly of intravenously (IV) delivered nanoparticles in ischemic skeletal muscle, which has applications for drug delivery to damaged muscle of the type prevalent in peripheral artery disease (PAD).

Graphical abstract: Enzyme-targeted nanoparticles for delivery to ischemic skeletal muscle
From the themed collection: Pioneering Investigators
Paper

Self-assembly of poly(vinylidene fluoride)-block-poly(2-(dimethylamino)ethylmethacrylate) block copolymers prepared by CuAAC click coupling

Self-assembly of PDMAEMA-b-PVDF block copolymers.

Graphical abstract: Self-assembly of poly(vinylidene fluoride)-block-poly(2-(dimethylamino)ethylmethacrylate) block copolymers prepared by CuAAC click coupling
From the themed collection: Pioneering Investigators
Paper

An indacenodithiophene-based semiconducting polymer with high ductility for stretchable organic electronics

An alkyl-substituted indacenodithiophene-based donor–acceptor π-conjugated polymer (PIDTBPD) with low stiffness and high ductility is reported.

Graphical abstract: An indacenodithiophene-based semiconducting polymer with high ductility for stretchable organic electronics
From the themed collection: Pioneering Investigators
Paper

A study of fused-ring thieno[3,4-e]pyrazine polymers as n-type materials for organic supercapacitors

Conjugated polymer pseudocapacitors achieve high capacitances because they store charge through fast, reversible redox reactions.

Graphical abstract: A study of fused-ring thieno[3,4-e]pyrazine polymers as n-type materials for organic supercapacitors
From the themed collection: Pioneering Investigators
Paper

Switchable 19F MRI polymer theranostics: towards in situ quantifiable drug release

A switchable polymeric 19F magnetic resonance imaging (MRI) contrast agent was synthesised whereby the transverse (T2) relaxation times increased as a therapeutic was released from a hyperbranched polymer (HBP) scaffold.

Graphical abstract: Switchable 19F MRI polymer theranostics: towards in situ quantifiable drug release
From the themed collection: Pioneering Investigators
Paper

Structure–cytotoxicity relationship of drug-initiated polymer prodrug nanoparticles

Cladribine (CdA)-based polymer prodrug nanoparticles were obtained by “drug-initiated” RAFT polymerization of squalenyl methacrylate (SqMA) from two different CdA-bearing chain transfer agents (CTAs) to evaluate the influence of the nature of the linkage between CdA and the CTA, and the bulkiness of the polymer, on the drug release and the biological performance.

Graphical abstract: Structure–cytotoxicity relationship of drug-initiated polymer prodrug nanoparticles
From the themed collection: Polymer Chemistry Lectureship Winners
Paper

Thermosensitive spontaneous gradient copolymers with block- and gradient-like features

Amphiphilic gradient copolymers with thermoresponsive properties were synthesized in one pot via RAFT copolymerization.

Graphical abstract: Thermosensitive spontaneous gradient copolymers with block- and gradient-like features
From the themed collection: Pioneering Investigators
Paper

Chalcogenide hybrid inorganic/organic polymers (CHIPs) via inverse vulcanization and dynamic covalent polymerizations

Poly(sulfur-random-styrene) was made via inverse vulcanization and used for dynamic covalent copolymerization (DCP) to incorporate novel vinylic monomers.

Graphical abstract: Chalcogenide hybrid inorganic/organic polymers (CHIPs) via inverse vulcanization and dynamic covalent polymerizations
From the themed collection: Pioneering Investigators
Paper

Hollow amphiphilic crosslinked nanocapsules from sacrificial silica nanoparticle templates and their application as dispersants for oil spill remediation

Hollow nanocapsules were constructed using a sacrificial silica scaffold to produce novel oil remediation agents.

Graphical abstract: Hollow amphiphilic crosslinked nanocapsules from sacrificial silica nanoparticle templates and their application as dispersants for oil spill remediation
From the themed collection: Pioneering Investigators
Paper

Norbornene-modified poly(glycerol sebacate) as a photocurable and biodegradable elastomer

Photocurable norbornene-functionalized poly(glycerol sebacate) (Nor-PGS) has been developed to fabricate cytocompatible, biodegradable and elastomeric scaffolds for tissue engineering applications.

Graphical abstract: Norbornene-modified poly(glycerol sebacate) as a photocurable and biodegradable elastomer
From the themed collection: Pioneering Investigators
Paper

1,2,3-Triazolium-based linear ionic polyurethanes

We report the synthesis and detailed characterization of a series of ionic polyurethanes issued from the polyaddition of a 1,2,3-triazolium-functionalized diol monomer having a bis(trifluoromethylsulfonyl)imide counter-anion with four aliphatic, cycloaliphatic or aromatic commercial diisocyanates.

Graphical abstract: 1,2,3-Triazolium-based linear ionic polyurethanes
From the themed collection: Pioneering Investigators
Paper

A comprehensive kinetic study of the conventional free-radical polymerization of seven-membered cyclic ketene acetals

The current study reports on the kinetic analysis of the free-radical polymerization of several seven-membered cyclic ketene acetal monomers.

Graphical abstract: A comprehensive kinetic study of the conventional free-radical polymerization of seven-membered cyclic ketene acetals
From the themed collection: Pioneering Investigators
Paper

A mechanistic investigation of Pickering emulsion polymerization

Unravelling the mechanism of Pickering emulsion polymerization using silica nanoparticles as the stabilizer.

Graphical abstract: A mechanistic investigation of Pickering emulsion polymerization
From the themed collection: Pioneering Investigators
Paper

Exploring structural effects in single-chain “folding” mediated by intramolecular thermal Diels–Alder chemistry

We describe a method to fold single polymer chains into nanoparticles using simple thermal Diels–Alder (DA) chemistry.

Graphical abstract: Exploring structural effects in single-chain “folding” mediated by intramolecular thermal Diels–Alder chemistry
From the themed collection: Pioneering Investigators
Paper

Preparation of polythiophene microrods with ordered chain alignment using nanoporous coordination template

The properties of polymeric materials can be amplified by macromolecular alignment.

Graphical abstract: Preparation of polythiophene microrods with ordered chain alignment using nanoporous coordination template
From the themed collection: Pioneering Investigators
Paper

Ethylene polymerization catalyzed by dinickel complexes with a double-decker structure

Double-decker dinickel catalysts, even without any substituent on an ortho-position, afforded high molecular weight polyethylene with high crystallinity and less branching.

Graphical abstract: Ethylene polymerization catalyzed by dinickel complexes with a double-decker structure
From the themed collection: Pioneering Investigators
Paper

Synthesis of aliphatic polycarbonates with a tuneable thermal response

The synthesis of aliphatic polycarbonates with a tuneable thermal-response is reported by a ‘click-and mix’ approach.

Graphical abstract: Synthesis of aliphatic polycarbonates with a tuneable thermal response
From the themed collection: Pioneering Investigators
Paper

Sustainable polyvinyl acetals from bioaromatic aldehydes

Water-degradable polyvinyl acetals with high glass transition temperatures (114–157 °C) were made via acetalization of polyvinyl alcohol (PVA) with bioaromatic aldehydes.

Graphical abstract: Sustainable polyvinyl acetals from bioaromatic aldehydes
From the themed collection: Pioneering Investigators
Open Access Paper

The hydrolytic behavior of N,N′-(dimethylamino)ethyl acrylate-functionalized polymeric stars

Well-defined N,N′-(dimethylamino)ethyl acrylate (DMAEA) functionalized polymeric stars have been synthesized via an arm-first approach.

Graphical abstract: The hydrolytic behavior of N,N′-(dimethylamino)ethyl acrylate-functionalized polymeric stars
From the themed collection: Pioneering Investigators
Paper

Improving tumor chemotherapy effect using an injectable self-healing hydrogel as drug carrier

A self-healing hydrogel has been used as the anti-tumor drug carrier to improve the chemotherapy effect.

Graphical abstract: Improving tumor chemotherapy effect using an injectable self-healing hydrogel as drug carrier
From the themed collection: Pioneering Investigators
Paper

One-shot controlled/living copolymerization for various comonomer sequence distributions via dual radical and cationic active species from RAFT terminals

One-shot control of comonomer sequence distributions was demonstrated by dual radical and cationic copolymerization using RAFT mediator.

Graphical abstract: One-shot controlled/living copolymerization for various comonomer sequence distributions via dual radical and cationic active species from RAFT terminals
From the themed collection: Pioneering Investigators
Paper

Shape memory polymer foams prepared from a heparin-inspired polyurethane/urea

Shape memory foams have been prepared using a heparin-inspired polyurea/urethane that displays excellent resistance to platelet adherence.

Graphical abstract: Shape memory polymer foams prepared from a heparin-inspired polyurethane/urea
From the themed collection: Pioneering Investigators
Paper

Oxygen tolerant photopolymerization for ultralow volumes

A benchtop approach is developed for the synthesis of various polymeric architectures using an aqueous Reversible Addition–Fragmentation chain Transfer (RAFT) photopolymerization technique.

Graphical abstract: Oxygen tolerant photopolymerization for ultralow volumes
From the themed collection: Polymer Chemistry Lectureship Winners
Paper

Poly(glycerol sebacate) nanoparticles for encapsulation of hydrophobic anti-cancer drugs

Physical encapsulation of hydrophobic compounds into nanocarriers that are stable in aqueous medium is of high interest as it can increase solubilization of the drug, lower its toxicity, control its pharmacokinetic profile and thus overall improve the therapeutic efficacy.

Graphical abstract: Poly(glycerol sebacate) nanoparticles for encapsulation of hydrophobic anti-cancer drugs
From the themed collection: Pioneering Investigators
36 items

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