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Thermosensitive Spontaneous Gradient Copolymers with Block- and Gradient-like Features


Reversible addition-fragmentation chain transfer (RAFT) copolymerization was used to prepare copolymers of N-isopropyl acrylamide (NIPAM) and vinyl acetate (VAc) and with mole fractions of NIPAM ranging from 0.1 to 0.6 and targeted degrees of polymerization of 100 and 250. The measured kinetic parameters and obtained experimental results revealed that this copolymerization system leads to a “one pot” synthesis of amphiphilic gradient copolymers, which have thermoresponsive and self-assembly characteristics resembling those of the analogous block copolymers but with some intriguing differences. Their self-assembly behavior in water suggests the formation of dynamic aggregates which respond rapidly to changes in solubility as revealed 1H NMR spectroscopy, in contrast to the kinetically frozen aggregates formed by block copolymers. Furthermore, despite their block-like composition profiles, these copolymers display a single, broad glass transition, as is typically found in linear gradient copolymers. The synthetic approach presented in this contribution could readily be adapted to other comonomer systems to provide an accessible and economic alternative to the conventional multi-step preparation of block copolymers.

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Publication details

The article was received on 23 Mar 2017, accepted on 19 Apr 2017 and first published on 19 Apr 2017

Article type: Paper
DOI: 10.1039/C7PY00495H
Citation: Polym. Chem., 2017, Accepted Manuscript
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    Thermosensitive Spontaneous Gradient Copolymers with Block- and Gradient-like Features

    R. Yañez-Macias, I. Kulai, J. Ulbrich, T. Yildirim, P. Sungur, S. Hoeppener, R. Guerrero-Santos, U. S. Schubert, M. Destarac, C. Guerrero-Sanchez and S. Harrisson, Polym. Chem., 2017, Accepted Manuscript , DOI: 10.1039/C7PY00495H

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