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Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

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Abstract

We report nanoassemblies based on block copolymers of N-(2-hydroxypropyl)methacrylamide (HPMA) in which drug cleavage enhances the biological compatibility of the original polymer carrier by regeneration of HPMA units. Drug release via ester hydrolysis suggests this approach offers potential for stimuli-responsive drug delivery under acidic conditions.

Graphical abstract: Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

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Publication details

The article was received on 02 Feb 2017, accepted on 12 Feb 2017 and first published on 22 Feb 2017


Article type: Communication
DOI: 10.1039/C7PY00196G
Citation: Polym. Chem., 2017, Advance Article
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    Poly(N-(2-hydroxypropyl)methacrylamide)–valproic acid conjugates as block copolymer nanocarriers

    J. A. Alfurhood, H. Sun, C. P. Kabb, B. S. Tucker, J. H. Matthews, H. Luesch and B. S. Sumerlin, Polym. Chem., 2017, Advance Article , DOI: 10.1039/C7PY00196G

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