Themed collection Soft Matter Open Access Spotlight


Complex remodeling of biomembranes and vesicles by condensate droplets
Condensate droplets arise from phase separation into two liquid phases α (white) and β (green). Vesicle membranes exposed to such droplets are divided up into two membrane segments (red and purple), which can form membrane nanotubes.
Soft Matter, 2025,21, 7370-7392
https://doi.org/10.1039/D5SM00585J

Materials science underpinnings of micro and nanoplastics
In this perspective, we discuss the fundamental mechanisms and the length scales responsible for the formation of micro- and nanoplastics (MNPLs), MNPL size, shape, and morphologies, their metrology, and open questions in the field.
Soft Matter, 2025,21, 6023-6033
https://doi.org/10.1039/D5SM00297D

Morphogenesis of confined biofilms: how mechanical interactions determine cellular patterning and global geometry
Bacterial biofilms that grow under confinement can mechanically interact with their environment to generate various global geometries and forms of cellular patterning.
Soft Matter, 2025,21, 1436-1450
https://doi.org/10.1039/D4SM01180E

(Sub-)microscale patterning via microcontact printing (μCP): recent advances, applications and future perspectives
Microcontact printing (μCP) is a versatile and low-cost technique for surface patterning, allowing for the fabrication of intricate designs with relative ease.
Soft Matter, 2025,21, 6658-6678
https://doi.org/10.1039/D5SM00355E

Co-assembly of nanometer- and submicrometer-sized colloidal particles into multi-component ordered superstructures
The co-assembly of nanometer- and submicrometer-sized colloidal particles can result in multi-component superstructures with unique properties.
Soft Matter, 2025,21, 5583-5654
https://doi.org/10.1039/D5SM00247H

Curvature-sensing and generation by membrane proteins: a review
We review the recent theoretical and simulation studies on interactions between curvature-inducing proteins and membranes.
Soft Matter, 2025,21, 3922-3940
https://doi.org/10.1039/D5SM00101C

Polyvinyl alcohol-based polarizers for new displays: molecules, processing and properties
This review clarifies the structure–process–property relationship in PVA-based polarizers.
Soft Matter, 2025,21, 3148-3167
https://doi.org/10.1039/D4SM01530D

Recent advances in nanoprecipitation: from mechanistic insights to applications in nanomaterial synthesis
Nanoprecipitation is a versatile, low-energy technique for synthesizing nanomaterials through phase separation, enabling precise tuning of nanomaterial properties.
Soft Matter, 2025,21, 2759-2781
https://doi.org/10.1039/D5SM00006H

Ion-conducting polymer thin films via chemical vapor deposition polymerization
Ion-conducting polymers (ICPs) are gaining interest in various scientific and technological fields. This review highlights advancements in ICP thin films using chemical vapor deposition (CVD) and addresses challenges of traditional methods.
Soft Matter, 2025,21, 1813-1834
https://doi.org/10.1039/D4SM01346H

Network design for soft materials: addressing elasticity and fracture resistance challenges
This review explores network designs that address the trade-off between toughness and elasticity, offering strategies to develop materials with both high fracture resistance and low hysteresis for advanced applications.
Soft Matter, 2025,21, 1603-1623
https://doi.org/10.1039/D4SM01430H

Liquid slide electrification: advances and open questions
This review is about drops of a liquid with high dielectric permittivity that slide over a solid surface with high electrical resistivity.
Soft Matter, 2025,21, 1251-1262
https://doi.org/10.1039/D4SM01289E

A tutorial for mesoscale computer simulations of lipid membranes: tether pulling, tubulation and fluctuations
A tutorial review on mesoscale computer simulations of fluid lipid membranes presenting three tutorials with repositories of ready-to-run codes for tether pulling, membrane tubulation and membrane fluctuation analysis.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00148J

Optical coherence tomography in soft matter
Optical coherence tomography (OCT) has been introduced through detailed tutorials, accompanied by a code package, as a powerful technique suitable for versatile investigations in fluid mechanics and soft matter physics.
Soft Matter, 2025,21, 3425-3442
https://doi.org/10.1039/D4SM01537A

Droplet spreading in a wedge: a route to fluid rheology for power-law liquids
The spreading of a drop in a wedge shows anomalous diffusion scaling, with the diffusion exponent directly linked to the fluid's rheological properties.
Soft Matter, 2025,21, 7014-7020
https://doi.org/10.1039/D5SM00286A

Free energy modelling of a spherical nanoparticle at an oil/water interface
In models of Pickering emulsion stabilisation, it is assumed that Young’s equation defines the angle of a solid particle at the oil/water interface. Here, we consider the implications for stability when the particle is displaced by an external force.
Soft Matter, 2025,21, 5188-5193
https://doi.org/10.1039/D5SM00501A

Microrheology of gel-forming airway mucins isolated from porcine trachea
A method to extract gel-forming mucins from pig trachea is developed. These airway mucins form viscous gels resembling human airway mucus, making them a useful model for lung disease research.
Soft Matter, 2025,21, 4999-5004
https://doi.org/10.1039/D4SM01343C

Transport of partially active polymers in chemical gradients
Connecting active and passive monomers to form partially active polymers can lead to directed transport towards regions of high or low chemical concentration.
Soft Matter, 2025,21, 1835-1840
https://doi.org/10.1039/D4SM01357C

Emulsification of lyotropic lamellar phases: new formulation routes for stabilized water-in-water emulsions
A new, simple and robust strategy for stabilizing water-in-water emulsions with coatings formed by a lamellar phase.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00748H

Controlling the local compliances of cruciform samples to probe equibiaxial failure
The cruciform sample geometry is redesigned to enable the measurement of uniaxial and equibiaxial failure stresses of a silicone elastomer that agree with the stresses observed in control measurements.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00644A

Cyclic loading of a heterogeneous non-linear poroelastic material
The solid strain and fluid flux response to cyclic loading of a poroelastic material with material heterogeneity are studied. The effect is found to vary with the type of load and heterogeneity, and is non-negligeable.
Soft Matter, 2025,21, 7487-7507
https://doi.org/10.1039/D5SM00580A

Signatures of polar order in a ferroelectric nematic liquid crystal: splay stiffening and twist softening
The recent discovery of ferroelectric nematics—genuine 3D ferroelectric fluids—has underscored the importance of electrostatic interactions in shaping the physical behaviour of soft matter systems.
Soft Matter, 2025,21, 7508-7518
https://doi.org/10.1039/D5SM00670H

Cell-scale dynamic modeling of membrane interactions with arbitrarily shaped particles
Time-resolved wrapping dynamics of anisotropic particles by fluid vesicles is modeled using a force-based triangulated surface framework. Simulations reveal nontrivial uptake pathways featuring sequential orientational transitions.
Soft Matter, 2025,21, 7420-7432
https://doi.org/10.1039/D5SM00567A

Dispersion behaviour of insoluble particles with different surface properties in non-aqueous media – biopolymer based oleogels
Illustration of the similarities and differences between dispersions of silica and plant protein particles as oil-structuring agents.
Soft Matter, 2025,21, 7460-7475
https://doi.org/10.1039/D5SM00596E

Comparison of acid- and base-catalysed sol–gel synthesis for the in situ crystallisation of a perovskite
We present a systematic comparison of acid- and base-catalysed silica ionic gels. These gels were compared based on the appearance, morphology, surface and porosity, and their practical utility in gel diffusion crystal growth of bismuth perovskites.
Soft Matter, 2025,21, 7476-7486
https://doi.org/10.1039/D5SM00608B

Polymer solution flow transitions and scaling laws for changing contraction ratios in planar constriction microchannels
The contraction and expansion flows positively correlate to the contraction ratio, CR, for all tested fluids except for polyethylene oxide solution which destabilizes (left plot) and grows vortices (right plot) nonmonotonically for CR alterations.
Soft Matter, 2025,21, 7404-7419
https://doi.org/10.1039/D5SM00688K

High throughput estimates of surface tension using steady droplet deformation in pressure-driven fluidic flows
High throughput surface tension measurements using steady droplet deformation and velocity in pressure driven flow (orange) compare well with pendant drop (blue).
Soft Matter, 2025,21, 7433-7448
https://doi.org/10.1039/D5SM00493D

Sedimentation equilibrium as a probe of the pressure equation of state of active colloids
We introduce a theoretical and computational framework for extracting the pressure equation of state (EoS) of an active suspension from its steady-state sedimentation profile.
Soft Matter, 2025,21, 7449-7459
https://doi.org/10.1039/D5SM00628G

Surfactant-laden micro-scale droplet coalescence in Bancroft-breaking systems
Microfluidic experiments show droplets coalescence criteria with viscosity ratio and surfactant concentration, and non-monotonic film drainage time is observed.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D4SM00644E

Protein condensates induce biopolymer filament bundling and network remodeling via capillary interactions
Protein condensate adsorption and spreading on actin filaments is investigated using fluorescence microscopy. We show condensates form capillary bridges that bundle filaments and induce network remodeling.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00508F

Diffusive probe penetration for characterization of diffusion-governing length scales in amphiphilic PEG–PCL co-networks
We determine the correlation length and hydrodynamic screening length of an amphiphilic PEG–PCL co-network and analyze their dependence on network composition to establish scaling laws for the targeted design of diffusion-based APCN applications.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00629E

Local deformation and dynamics of cross-linked hyaluronic acid gels at charged interfaces
Charged hydrogel adhesion and repulsion strongly depends on the surface charge and ionic environment. Oppositely charged surfaces deform the gels locally, while similarly charged surfaces lead to a hydration layer.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00616C

Tuning the size and stiffness of inflatable particles
We create inflatable particles that can stiffen or soften during inflation utilizing strain localization.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00808E

Branching dynamics in electrohydrodynamic instabilities of viscoelastic soft gels
The neutral stability curve gives the critical potential vs. wavenumber, with the straight line marking the transition wavenumber. Left of the intersection shows supercritical saturation, while the right side indicates subcritical rupture.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00727E

Transient interactions and local heterogeneity drive rotational–translational decoupling of nanorods in semidilute mucin solutions
We investigated the rotational and translational dynamics of gold nanorods in semidilute solutions of bovine submaxillary mucin (BSM), a biologically relevant bottlebrush polymer rich in MUC5B.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00742A

Activation of colloidal patchy particle networks
Networks of colloidal patchy particles exhibit a rich dynamical response when activated by self-propelled particles with moderate activity.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00615E

Programmable rheotaxis of magnetic rollers in time-varying fields
Time-varying fields direct ferromagnetic spheres to migrate with, against, or across shear flows, enabling self-guided microrobots to navigate surfaces without external feedback.
Soft Matter, 2025,21, 7344-7353
https://doi.org/10.1039/D5SM00682A

Multifunctional poly(ionic liquid)/graphitic carbon nitride membranes: visible light-driven photodegradation coupled with antifouling properties
Poly(ionic liquid) membranes with carbon nitride nanoparticle incorporation exhibit advanced properties.
Soft Matter, 2025,21, 7289-7307
https://doi.org/10.1039/D5SM00441A

On the self-assembly of αB-crystallin
In this work the self-assembly of the chaperone αB-crystallin is shown to follow the closed association model to a good approximation. The oligomeric form is found to consist of 18 monomers, approximately 7 nm in radius, independent of concentration.
Soft Matter, 2025,21, 7308-7317
https://doi.org/10.1039/D5SM00684H

Geometric frustration in twist-bend nematic droplets
We study textures formed in spherical droplets of twist-bend nematic liquid crystal with radial anchoring.
Soft Matter, 2025,21, 7270-7288
https://doi.org/10.1039/D5SM00530B

Lattice-dependent orientational order in active crystals
Crystals made of active particles that turn either toward or away from each other achieve states with orientational order that depends on the underlying crystalline lattice.
Soft Matter, 2025,21, 7228-7236
https://doi.org/10.1039/D5SM00627A

Hyperelastic characterization via deep indentation
Hyperelastic material characterization is crucial for understanding the behavior of soft materials—such as tissues, rubbers, hydrogels, and polymers—under quasi-static loading before failure.
Soft Matter, 2025,21, 7354-7360
https://doi.org/10.1039/D5SM00502G

Facile conversion of commercial silicones from thermoset to ultraviolet-set for increased processing versatility
This article demonstrates how to convert commercial thermoset silicone kits to UV-set materials following a convenient, easily accessible protocol.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00700C

Biomolecular condensate microstructure is invariant to sequence-encoded molecular and macroscopic properties
Coarse-grained simulations reveal that the internal organization of biomolecular condensates is robust to diverse arrays of sequence-encoded molecular and macroscopic properties.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00740B

Chirality and concentration govern polycatecholamine self-assembly: a comparative study of dopamine, levodopa, and norepinephrine
Precursor chemistry, concentration and chirality control polycatecholamine (pCA) polymerization. Analysis of dopamine, levodopa and norepinephrine reveals distinct kinetic and particle aggregation profiles for the rational design of pCA surfaces.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00718F

A unified approach to suspension cell mechanics
Power law rheology of HL60 cells renders mechanical measurements largely independent of experimental method, timescale and adhesion or suspension state. Specifically, the resting Young's modulus is not affected by buffer composition and viscosity.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00414D

Defect interactions through periodic boundaries in two-dimensional p-atics
The interaction between topological defects in 2D p-atics with periodic boundary conditions is different than Coulomb charges in the same configuration. This is due to topological solitons that are stabilized by the nontrivial domain topology.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00773A

Slipping and fluidisation in active crystalline rotors
Quincke roller active colloids self-assemble under confinement into rotors. A “magic number” of 61 particles forms a tiny crystallite which rotes and undergoes a series of slipping transitions as activity is increased.
Soft Matter, 2025,21, 7155-7164
https://doi.org/10.1039/D5SM00109A

Cation selectivities in zwitterion grafted nanopores: effect of zwitterion architecture
We conducted molecular dynamics simulations of aqueous salt solutions in the zwitterion-functionalized nanopore. Our results showed that reversing ZI dipole orientation promotes permselectivity of Na+/Cs+ over Li+ among monovalent cations.
Soft Matter, 2025,21, 7110-7124
https://doi.org/10.1039/D5SM00687B

Bacterial cell membrane models: choosing the lipid composition
Each lipid type in a model membrane influences membrane properties.
Soft Matter, 2025,21, 7054-7073
https://doi.org/10.1039/D5SM00378D

Nanotubes of pristine poly(3-hexylthiophene) with modulable conductive properties: the interplay between confinement-induced orientation and interfacial effects
Nanotubes of P3HT exhibit broadly modulable conductive properties in dependence on their thickness. Conductivity values higher for P3HT nanotubes than for the bulk or P3HT nanowires are reported, due to orientation effects.
Soft Matter, 2025,21, 7144-7154
https://doi.org/10.1039/D5SM00507H

Iso- to anisotropic wetting on microwrinkled surfaces with varying intrinsic wettability
We examine the combined effects of topography and intrinsic material wettability on the overall wetting behaviour of patterned surfaces, with widespread practical applications.
Soft Matter, 2025,21, 7125-7134
https://doi.org/10.1039/D5SM00525F

Cell mechanics, environmental geometry, and cell polarity control cell–cell collision outcomes
When cells attached to parallel nanofibers collide, they can form a train, reverse from the collision, or walk past each other. Simulations and linear stability analysis show the outcome depends on cell deformability, positive feedback of polarity, and fiber spacing.
Soft Matter, 2025,21, 7074-7090
https://doi.org/10.1039/D5SM00359H

Interplay of the structures and viscoelastic properties of polyampholyte gels with the interlude of neutral blocks
The reversible dissociation–association dynamical process of the ionic bonds offers gels excellent self-healing properties.
Soft Matter, 2025,21, 7042-7053
https://doi.org/10.1039/D5SM00407A

Active sorting to boundaries in active nematic–passive isotropic fluid mixtures
Extensile active flows drive sorting to an anchored boundary in an active nematic–passive isotropic fluid mixture.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00636H

Quantifying experimental errors in measuring colloidal interaction potentials with optical tweezers
We experimentally quantify the key error sources in optical tweezer measurements and systematically model their impact on the extraction of interaction potentials.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00551E

Emergence and evolution of a particulate network during gelation and coarsening of attractive colloids
Colloidal gelation involves formation of an interconnected and percolated network of particles, followed by its coarsening and maturation. We present quantitative analysis of this network through different structural and dynamical measures.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00572H

Coupling anisotropic curvature and nematic order: mechanisms of membrane shape remodeling
This study theoretically investigates how anisotropic curved membrane components (CMCs) control vesicle morphology through curvature sensing, nematic alignment, topological defects and volume constraints.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00620A

Tunable defect patterns induced by a low-frequency electric field in ferroelectric nematic liquid crystals
We investigate the generation of square-lattice defect arrays in ferroelectric nematic liquid crystals under the influence of an alternating field. The parameters of the structure depend on the frequency of the applied field and could be tuned.
Soft Matter, 2025, Advance Article
https://doi.org/10.1039/D5SM00747J

From single microgels to dense microgel monolayers – investigation by atomic force microscopy
Microgel monolayers at the solid–liquid interface are investigated using force spectroscopy with a sharp AFM tip. We show the effect of the lateral compression on the properties and internal structure of our microgels.
Soft Matter, 2025,21, 6984-6994
https://doi.org/10.1039/D5SM00522A

Phase behavior of catenated-linear DNA mixtures
This study highlights topology's role in the phase behavior of polymer blends: catenated DNA network (kDNA)-linear DNA (λ-DNA) mixtures phase separates above a critical λ-DNA concentration, unlike circular-linear blends which remain uniformly mixed.
Soft Matter, 2025,21, 6919-6929
https://doi.org/10.1039/D5SM00461F

Deciphering supramolecular and polymer-like behavior in metallogels: real-time insights into temperature-modulated gelation and rapid self-assembly dynamics
Bis(pyridyl) urea gelators (L2, L1 + L2) self-assemble into anisotropic fibrillar networks; L2 forms dense, entangled gels, while L1 + L2 shows distinct, dynamic morphologies, revealing isomer-specific assembly pathways.
Soft Matter, 2025,21, 6963-6974
https://doi.org/10.1039/D5SM00420A

Phase-field model for quantitative analysis of droplet wetting
A phase-field algorithm is used to quantitatively describe wetting morphologies.
Soft Matter, 2025,21, 6937-6952
https://doi.org/10.1039/D5SM00593K

Modelling transcriptional silencing and its coupling to 3D genome organisation
Using 3D simulations, this study uncovers how distinct gene silencing mechanisms reshape chromatin, modulate gene expression noise, and drive unique transcription factor cluster patterns—revealing hidden dynamics of genome regulation.
Soft Matter, 2025,21, 6975-6983
https://doi.org/10.1039/D5SM00686D

Dynamic self-organization in fire ant rafts underpins collective longevity and threat responsiveness
Fire ant rafts dynamically self-organize to conserve energy by separating into active and inactive phases, through formation of stationary clusters that can dissolve rapidly under external stimuli, enabling a swift decentralized collective response.
Soft Matter, 2025,21, 6879-6890
https://doi.org/10.1039/D5SM00390C

Turbulent-like flows in quasi two-dimensional dense suspensions of motile colloids
Dense suspensions of Quincke random walkers exhibit turbulent-like flows mimicking those of bacterial suspensions.
Soft Matter, 2025,21, 6852-6858
https://doi.org/10.1039/D5SM00192G

Structural complexity driven by liquid–liquid crystal phase separation of smectics
Demixing of smectics can exhibit a diverse range of condensate morphologies. Here we demonstrate that solvent swelling of the smectic can reduce layer bending rigidity, giving rise to more structurally-complex morphologies.
Soft Matter, 2025,21, 6751-6761
https://doi.org/10.1039/D5SM00487J

Patterns with long and short-range order in monoloyers of binary mixtures with competing interactions
Patterns with long- and short-range order in a monolayer of a self-assembling mixture of particles or macromolecules are studied by MD simulations in a generic model inspired by biological and soft matter systems.
Soft Matter, 2025,21, 6801-6813
https://doi.org/10.1039/D5SM00543D

Errors matter when measuring Poisson's ratio of nearly incompressible elastomers
Multiple pathways exist for measuring Poisson’s ratio. Not all methods are appropriate for nearly incompressible materials.
Soft Matter, 2025,21, 6689-6696
https://doi.org/10.1039/D5SM00535C

Microfluidic memristive oscillators as universal logic gates for neuromorphic computing
To combat the ever growing energy demand of machine learning, we design novel, neuromorphic, iontronic circuits inspired by Shinriki oscillators and based on microfluidic memristors. We show that they form the universal logic NAND gate.
Soft Matter, 2025,21, 6707-6716
https://doi.org/10.1039/D5SM00601E

Stabilizing light-responsive azobenzene films in an aqueous environment with thin polymer coatings
PDMS and parylene C coatings on azobenzene films are compared. Both enable surface relief grating inscription in water, however parylene C offers improved biocompatibility, cell adhesion, and stability, making it ideal for cell culture applications.
Soft Matter, 2025,21, 6779-6790
https://doi.org/10.1039/D5SM00563A
About this collection
Browse our 2025 Open Access articles!
All featured articles are published Gold Open Access and are free to read in Soft Matter.