Themed collection Journal of Materials Chemistry B Recent Review Articles
Engineering microbes to synthesize functionalized biopolymers
Engineering the metabolism of microbes has allowed simultaneous co-production of functional small molecules and biopolymers.
Chemical and molecular tools to probe biological sex differences at multiple length scales
Sex differences in biology are observed at multiple different length scales and across organ systems.
Fluidic enabled bioelectronic implants: opportunities and challenges
Fluidics are enabling new possibilities in bioelectronic medicine and research.
The importance of water content on the conductivity of biomaterials and bioelectronic devices
Water content derived from the environment is as an important a variable as temperature for affecting the conductivity and for understanding the charge transport mechanisms within conductive biomaterials as well as bioelectronic devices.
Active nanomotors surpass passive nanomedicines: current progress and challenges
We summarise the superiorities of nanomotors over traditional nanomedicines, state-of-the-art applications and current challenges of using nanomotors in the biomedical field.
Carbon-based nanostructures for cancer therapy and drug delivery applications
Carbon-based nanostructures as drug carriers have attracted a great deal of interest over the past half of the century because of their promising chemical, thermal, physical, optical, mechanical, electrical properties, and their structural diversity.
Effective design of organic luminogens for near-infrared-II fluorescence imaging and photo-mediated therapy
Organic luminogens possess excellent photonic features that are essential for biomedical applications.
Biomedical polymer scaffolds mimicking bone marrow niches to advance in vitro expansion of hematopoietic stem cells
Hematopoietic stem cell (HSC) transplantation provides an effective platform for the treatment of hematological disorders.
Multicomponent carrier-free nanodrugs for cancer treatment
This article outlines the construction strategies of multi-component carrier-free nanodrugs based on the fundamental properties of their constituent substances (organic/inorganic and hydrophilic/hydrophobic), and prospects for the development.
Lanthanide-based MOFs: synthesis approaches and applications in cancer diagnosis and therapy
Metal–organic frameworks (MOFs) have attracted considerable attention as emerging nanomaterials.
Advances in microRNA from adipose-derived mesenchymal stem cell-derived exosome: focusing on wound healing
ADMSC-Exo-miRNAs as therapeutic strategies for wound healing.
A review on in vitro/in vivo response of additively manufactured Ti–6Al–4V alloy
This review paper introduced a novel 3B-based classification (Biofunctionality, Bioactivity, Biostability), which mainly governs native body response, to provide a comprehensive overview to examine the in vitro and in vivo responses of additively manufactured Ti64 implants.
Application of bioactive metal ions in the treatment of bone defects
In recent years, the research of metal ions has become more extensive in bone tissue engineering. We review the mechanism and application of metal ions in the treatment of different pathological types of bone defects in bone tissue engineering.
Surface antimicrobial functionalization with polymers: fabrication, mechanisms and applications
In this review, the development, mechanism and applications of antimicrobial surfaces with polymer-based modification strategies are highlighted.
Bioinspired porphyrin–peptide supramolecular assemblies and their applications
This paper summarizes the different assembly strategies adopted in recent years, the effects of driving forces on self-assembly, and the application of porphyrin–peptides, and briefly discusses the challenges and prospects for future research.
Getting drugs to the brain: advances and prospects of organic nanoparticle delivery systems for assisting drugs to cross the blood–brain barrier
Organic-nanoparticles (NPs) delivery systems for crossing the blood–brain barrier.
Chondroitin sulfate-based composites: a tour d’horizon of their biomedical applications
Chondroitin sulfate (CS), a natural anionic mucopolysaccharide, belonging to the glycosaminoglycan family, has been in the limelight for its unique properties in diverse biomedical applications.
When 2D nanomaterials meet biomolecules: design strategies and hybrid nanostructures for bone tissue engineering
2D nanomaterials show great potential in bone tissue engineering due to their unique physical and chemical surface properties.
Biobased polymer resources and essential oils: a green combination for antibacterial applications
Essential oils (EOs) can act as natural biocide agents when introduced in renewable/bio-based polymers. The nature of EOs influences the mechanical properties and the antibacterial activities of the final bio-based materials.
Metal-porphyrinic framework nanotechnologies in modern agricultural management
Metal-porphyrinic frameworks find multiple important applications in agriculture based on their rich properties including semi-conductivity, strong absorption of visible light and fluorescence, porosity, and photosensitization of singlet oxygen.
Nanomaterials and paper-based electrochemical devices: merging strategies for fostering sustainable detection of biomarkers
This review aims to analyze how the paper material offers unique and polyvalent properties to bridge together multiple uses of nanomaterials and develop electrochemical biosensors for application in the biomedical field.
Current status and future prospects of nanoscale metal–organic frameworks in bioimaging
The importance of diagnosis and in situ monitoring of lesion regions and transportation of bioactive molecules has a pivotal effect on successful treatment, reducing side effects, and increasing the chances of survival in the case of diseases.
Advances in applications of piezoelectronic electrons in cell regulation and tissue regeneration
We summarized the mechanisms of cellular response to piezoelectronic electrons and the applications of piezoelectronic electrons in cell regulation and tissue regeneration according to the types of cells and tissues.
Modulating liquid–liquid phase separation of FUS: mechanisms and strategies
This review summarizes the regulations of liquid–liquid phase separation involving fused in sarcoma protein (FUS) by physical stimuli, biochemical modulators and protein structural modifications.
Rare earth-doped nanocrystals for bioimaging in the near-infrared region
An overview of strategies from designing high-quality rare-earth-doped nanoparticles to bioimaging in the NIR region.
Biodegradable bioelectronics for biomedical applications
Primary materials for biodegradable bioelectronics: conductive materials blended with biodegradable components, conjugated polymers with biodegradable moieties, naturally derived conjugated biopolymers, and aqueously dissolvable inorganic materials.
Microfluidic-based functional materials: new prospects for wound healing and beyond
Microfluidics has been applied to fabricate high-performance functional materials contributing to all physiological stages of wound healing. The advances of microfluidic-based functional materials for wound healing have been summarized.
Advanced bioactive hydrogels for the treatment of myocardial infarction
Bioactive hydrogels exhibit physicochemical-responsive activities to repair infarcted myocardium and restore the cardiac function after myocardial infarction.
Polyethyleneimine-based immunoadjuvants for designing cancer vaccines
PEI-based cancer vaccines increase the cellular uptake of antigens and adjuvants by dendritic cells and promote activation and antigen cross-presentation to effectively cross-prime antigen-specific T cells and B cells for robust antitumor immunity.
Porous biomaterials for tissue engineering: a review
The field of porous biomaterials has grown rapidly over the past decades.
The design strategies and biological applications of probes for the gaseous signaling molecule hydrogen sulfide
Herein, we review the fluorescent probes for the detection of H2S levels and dynamics in living cells and organisms and discuss the design methods, response mechanisms, and applications.
Oxygenation therapies for improved wound healing: current trends and technologies
Oxygenation therapies for wound healing.
Nanotechnology-integrated ferroptosis inducers: a sharp sword against tumor drug resistance
This review introduces the roles of key ferroptosis-regulating molecules in the progression of drug resistance and reviews the design of ferroptosis-inducing strategies based on nanotechnology for overcoming drug resistance.
Stimuli-responsive delivery strategies for controllable gene editing in tumor therapeutics
The CRISPR system has attracted significant attention due to its great potential in tumor therapy.
Nanomaterial integrated 3D printing for biomedical applications
Herein, recent advances in nanomaterials integrated with 3D printing technologies are summarized to inform the reader about the cutting-edge technology in the development of advanced 3D-printed structures for biomedical applications.
Nucleic acid paranemic structures: a promising building block for functional nanomaterials in biomedical and bionanotechnological applications
This review highlights the PX-based DNA nanostructures in biological systems, dynamic systems, and biomedical contexts.
Emerging approaches for preventing cytokine release syndrome in CAR-T cell therapy
Strategies for reducing CRS in CAR-T cells capitalize on the specificity between CAR-T cells, cytokines, and their receptors, the role of macrophages in cytokine release, and genetic constructs to ablate CAR-T function reversibly and irreversibly.
Recent advances in nanotechnology mediated mitochondria-targeted imaging
Mitochondria play a critical role in cell growth and metabolism.
Molecularly imprinted polymers in diagnostics: accessing analytes in biofluids
Bio-applied molecularly imprinted polymers (MIPs) are biomimetic materials with tailor-made synthetic recognition sites, mimicking biological counterparts known for their sensitive and selective analyte detection.
Emerging nanobiotechnology-encoded relaxation tuning establishes new MRI modes to localize, monitor and predict diseases
Tumor microenvironment-activated longitudinal or transverse relaxation tuning shows highly promising applications. Smart MRI contrast agents exhibit high potential for tracking cancer progression and evolution and monitoring treatment process.
Recent advances in biomedical applications of bacterial outer membrane vesicles
This review comprehensively covers the extraction, characterization, functionalization and biomedical applications of bacterial outer membrane vesicles (OMVs).
Latest on biomaterial-based therapies for topical treatment of psoriasis
Biomaterials demonstrate great potential in the treatment of psoriasis.
Design of hydrogel-based wearable EEG electrodes for medical applications
We are in the evolution of continuous monitoring of neural activity with non-invasive wearable EEGs. The development of hydrogel electrodes technology is important for home-use systems for long-term EEG monitoring and diagnostics of disease.
Recent progress of nanomedicine in secreted phospholipase A2 as a potential therapeutic target
This paper systematically reviews recent studies on nanomedicines targeting sPLA2 overexpression in many inflammatory diseases and various types of cancer during the past few years.
Chitosan-based oral colon-specific delivery systems for polyphenols: recent advances and emerging trends
Chitosan has been widely used to assemble different types of oral colon-targeted delivery systems, which attract great attention in the delivery of polyphenols to the colon for the treatment of colon and non-colon diseases.
Conjugated polymer-based luminescent probes for ratiometric detection of biomolecules
We summarize the recent research progress concerning conjugated polymer-based luminescent probes for ratiometric detection of biomolecules.
Cell membrane-engineered nanoparticles for cancer therapy
This review mainly summarizes the research progress of cell membrane extraction and coating technology, with an emphasis on the treatment of cancer with cell membrane-engineered nanoparticles from various sources.
Recent advances in biomaterial-assisted cell therapy
This review summarizes the recent research progress in various cell therapies and surveys the biomaterials developed to assist cell-based therapeutics for wide applications in diverse disease treatments.
Hemostatic biomaterials to halt non-compressible hemorrhage
This review covers the design principles of hemostatic biomaterials based on biochemical and mechanical mechanisms, and discusses the remaining challenges and immediate opportunities to manage non-compressible hemorrhage with biomaterials.
Rational construction of polycystine-based nanoparticles for biomedical applications
This review summarizes the development of reduction-responsive disulfide-crosslinked PCys2-based nanoparticles through one-pot polymerization, post-polymerization modification, and post-polymerization self-assembly for biomedical applications.
Electrospun nanofibers for manipulating soft tissue regeneration
By integrating multiple types of guidance cues, electrospun nanofiber scaffolds can be used to manipulate cell behaviors and thus facilitate soft tissue regeneration, including nerves, skin, heart, blood vessels, and cornea.
Thioether-based ROS responsive polymers for biomedical applications
Thioether-based reactive oxygen species (ROS) responsive polymers and polypeptides, with the ability to self-assemble in aqueous media and disassemble or being transformed in the presence of ROS, are ideal candidates for target biomedical therapies.
Magnetomechanical force: an emerging paradigm for therapeutic applications
Magnetomechanical force for therapeutic applications.
Bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management
This review provides the recent progress, intrinsic interactions between structures and bioactive performances, current limitations and future directions of bioactive hydrogels based on polysaccharides and peptides for soft tissue wound management.
Biofunctionalized metal–organic frameworks and host–guest interactions for advanced biomedical applications
With highly favorable properties such as enormous internal surface areas, high porosity and large flexibility, metal–organic frameworks (MOFs) have emerged as promising materials for applications such as gas storage and separation, catalysis, wastewater filtration, etc.
Supramolecular biomaterials for enhanced cancer immunotherapy
Supramolecular self-assembly offers the possibility for modulating nanostructures and reprogramming immunological properties, paving the way for enhanced cancer immunotherapy.
Smart biomaterials and their potential applications in tissue engineering
Smart biomaterials have been rapidly advancing ever since the concept of tissue engineering was proposed.
Delivery process and effective design of vectors for cancer therapy
This review aims to summarize different drug delivery vehicles and delivery processes to provide ideas for effective cancer therapy.
Membrane-fusogenic biomimetic particles: a new bioengineering tool learned from nature
This review aims to highlight the recent advances, key limitations, and future directions of membrane-fusogenic biomimetic particles for biomedical applications.
Recent development in the design of artificial enzymes through molecular imprinting technology
Recent advances in the preparation of high-performance artificial enzymes based on MIPs and molecularly imprinted nanozymes.
Recent advances in protein-imprinted polymers: synthesis, applications and challenges
This review summarized the recent advances of protein imprinted polymers (PIPs) focused on the imprinting methods and highlighted applications.
Semiconducting polymer dots as fluorescent probes for in vitro biosensing
Semiconducting polymer dots (Pdots) are novel fluorescent probes with relatively high brightness, fast emission rate, and excellent photostability. This review systematically summarizes their applications for in vitro biosensing.
Connecting the dynamics and reactivity of arylboronic acids to emergent and stimuli-responsive material properties
The stimuli-responsive material properties of arylboronate ester-based materials originate from the dynamics and reactivity of arylboronic acids.
Electrospun nanofibers for bone regeneration: from biomimetic composition, structure to function
This review summarizes the advances in bone regeneration of electrospun nanofibers, focusing their compositions, structures, functions, and fabrication technologies, which provide guidance for design of electrospun nanofibers for bone regeneration.
An update on biomaterials as microneedle matrixes for biomedical applications
In this review, we have summarised and reviewed the current matrix materials used for the preparation of MNs in light of the five aspects. In addition, we conclude with a summary of the MN products used on the market and their applications.
Nanoparticles for oral delivery: targeted therapy for inflammatory bowel disease
As a group of chronic and idiopathic gastrointestinal (GI) disorders, inflammatory bowel disease (IBD) is characterized by recurrent intestinal mucosal inflammation.
Tannic acid: a versatile polyphenol for design of biomedical hydrogels
Tannic acid (TA), a natural polyphenol, is a hydrolysable amphiphilic tannin derivative of gallic with diverse potential for engineering biomedical hydrogels.
Recent advances in functionally modified polymers for mucoadhesive drug delivery
The functional modifications of polymers for mucoadhesive drug delivery and mucosal transport mechanism.
Aggressive strategies for regenerating intervertebral discs: stimulus-responsive composite hydrogels from single to multiscale delivery systems
Stimulus responsive composite hydrogels combines with ready-to-use particles to form multi-scale delivery system. After solidification in vivo, the biological agents slowly released induce stem cells to differentiate into IVD tissue.
Metal–organic frameworks as a therapeutic strategy for lung diseases
This review focuses on the design and application of MOF-based drugs against lung diseases, and discusses the possibility of preparing MOF-based inhalable formulations and the challenges and opportunities of MOFs in clinical applications targeting lung diseases.
About this collection
This collection contains recent Review-type articles published by Journal of Materials Chemistry B, the home for high impact applications, properties and synthesis of exciting new materials for biology and medicine. New articles will be added to this collection as soon as possible after publication.