Themed collection Drug design and discovery

The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anti-tuberculosis, anti-diabetic, and anti-Alzheimer drugs.

Benzofuran compounds are a class of compounds that are ubiquitous in nature.

Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and other diseases.

Alzheimer's disease is a progressive and irreversible neurodegenerative disease, associated with a decreased cognitive function and severe behavioral abnormalities.

Coumarin–chalcone hybrid is an interesting template for medicinal chemists to develop therapeutic agents with diverse pharmacological activity.

The purpose of this article is to provide an overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity.

The present article systematically gives a comprehensive review of current development of benzofuran-based compounds as antimicrobial agents and the perspectives that they hold for future research.

This review covers the current aspects of leishmaniasis including marketed drugs, new antileishmanial agents, and possible drug targets of antileishmanial agents.

Naphthoquinone moieties are present in drugs such as doxorubicin which are used clinically to treat solid cancers.

Pyrrole is widely known as a biologically active scaffold which possesses a diverse nature of activities.

In this critical review, we provide a comprehensive view of the chemistry of ortho-quinone methides as versatile reactive intermediates in organic synthesis.

Cyclic molecular frameworks, especially the benzannulated medium-sized and macrocyclic ring (BMR) systems, constitute an integral component of a large number of biologically significant natural or synthetic molecules.

Corydalis plants are rich sources of isoquinoline alkaloids with various biological activities as well as drug-like properties.

This review reports the development of multicomponent reactions over the last 10 years.

Teixobactin is a head to side-chain cyclic depsipeptide with a guanidino based residue within the cycle, three D-amino acids in the tail, and a N-methylated terminal residue.

Medicinal plants are widely used against diabetes mellitus. Here, we provide DiaNat-DB, the first publicly available database of secondary metabolites from medicinal plants, chemically characterized, and integrated with antidiabetic activity.

The synthetic efficacy and biological relevance extend an opportunity to further drug-discovery development of fluoro-spiro-isoxazolines as novel anti-viral and anti-cancer agents.

Small molecule cholinesterase (ChE) inhibitors represent one of the most effective therapeutic strategies for the treatment of Alzheimer's disease (AD).

Chikungunya virus (CHIKV) is an emerging arbovirus, which has recently become globally important.

Cytotoxic nickel(II) complexes with an N-substituted isatin thiosemicarbazone were synthesized and their interaction with CT DNA and BSA protein was investigated, which was supported by molecular docking studies.

In response to an increased demand for effective anticancer drugs, a series of disodium sulphonamides of L-glutamic acid (L1–L3) was synthesized. Sulphonamides were complexed with copper(II), nickel(II) and ruthenium(III) ions, separately and respectively.