Themed collection Drug design and discovery

21 items
Open Access Review Article

CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review

The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anti-tuberculosis, anti-diabetic, and anti-Alzheimer drugs.

Graphical abstract: CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review
From the themed collection: Chemistry in the battle against infections
Open Access Review Article

Natural source, bioactivity and synthesis of benzofuran derivatives

Benzofuran compounds are a class of compounds that are ubiquitous in nature.

Graphical abstract: Natural source, bioactivity and synthesis of benzofuran derivatives
From the themed collection: Drug design and discovery
Open Access Review Article

Recent developments in the synthesis and biological activity of acridine/acridone analogues

Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and other diseases.

Graphical abstract: Recent developments in the synthesis and biological activity of acridine/acridone analogues
From the themed collection: Drug design and discovery
Open Access Review Article

Two decades of new drug discovery and development for Alzheimer's disease

Alzheimer's disease is a progressive and irreversible neurodegenerative disease, associated with a decreased cognitive function and severe behavioral abnormalities.

Graphical abstract: Two decades of new drug discovery and development for Alzheimer's disease
From the themed collection: Drug design and discovery
Review Article

Coumarin–chalcone hybrids: promising agents with diverse pharmacological properties

Coumarin–chalcone hybrid is an interesting template for medicinal chemists to develop therapeutic agents with diverse pharmacological activity.

Graphical abstract: Coumarin–chalcone hybrids: promising agents with diverse pharmacological properties
From the themed collection: Drug design and discovery
Review Article

Selected organophosphorus compounds with biological activity. Applications in medicine

The purpose of this article is to provide an overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity.

Graphical abstract: Selected organophosphorus compounds with biological activity. Applications in medicine
From the themed collection: Chemistry in the battle against infections
Review Article

Benzofuran: an emerging scaffold for antimicrobial agents

The present article systematically gives a comprehensive review of current development of benzofuran-based compounds as antimicrobial agents and the perspectives that they hold for future research.

Graphical abstract: Benzofuran: an emerging scaffold for antimicrobial agents
From the themed collection: Drug design and discovery
Review Article

Antileishmanial drug discovery: comprehensive review of the last 10 years

This review covers the current aspects of leishmaniasis including marketed drugs, new antileishmanial agents, and possible drug targets of antileishmanial agents.

Graphical abstract: Antileishmanial drug discovery: comprehensive review of the last 10 years
From the themed collection: Drug design and discovery
Review Article

Understanding cancer and the anticancer activities of naphthoquinones – a review

Naphthoquinone moieties are present in drugs such as doxorubicin which are used clinically to treat solid cancers.

Graphical abstract: Understanding cancer and the anticancer activities of naphthoquinones – a review
From the themed collection: Drug design and discovery
Review Article

Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics

Pyrrole is widely known as a biologically active scaffold which possesses a diverse nature of activities.

Graphical abstract: Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics
From the themed collection: Drug design and discovery
Review Article

ortho-Quinone methide (o-QM): a highly reactive, ephemeral and versatile intermediate in organic synthesis

In this critical review, we provide a comprehensive view of the chemistry of ortho-quinone methides as versatile reactive intermediates in organic synthesis.

Graphical abstract: ortho-Quinone methide (o-QM): a highly reactive, ephemeral and versatile intermediate in organic synthesis
From the themed collection: Drug design and discovery
Review Article

Importance and synthesis of benzannulated medium-sized and macrocyclic rings (BMRs)

Cyclic molecular frameworks, especially the benzannulated medium-sized and macrocyclic ring (BMR) systems, constitute an integral component of a large number of biologically significant natural or synthetic molecules.

Graphical abstract: Importance and synthesis of benzannulated medium-sized and macrocyclic rings (BMRs)
From the themed collection: Drug design and discovery
Review Article

Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis

Corydalis plants are rich sources of isoquinoline alkaloids with various biological activities as well as drug-like properties.

Graphical abstract: Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis
From the themed collection: Drug design and discovery
Review Article

Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis

This review reports the development of multicomponent reactions over the last 10 years.

Graphical abstract: Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis
From the themed collection: Drug design and discovery
Communication

Re-evaluation of the N-terminal substitution and the D-residues of teixobactin

Teixobactin is a head to side-chain cyclic depsipeptide with a guanidino based residue within the cycle, three D-amino acids in the tail, and a N-methylated terminal residue.

Graphical abstract: Re-evaluation of the N-terminal substitution and the D-residues of teixobactin
From the themed collection: Drug design and discovery
Open Access Paper

DiaNat-DB: a molecular database of antidiabetic compounds from medicinal plants

Medicinal plants are widely used against diabetes mellitus. Here, we provide DiaNat-DB, the first publicly available database of secondary metabolites from medicinal plants, chemically characterized, and integrated with antidiabetic activity.

Graphical abstract: DiaNat-DB: a molecular database of antidiabetic compounds from medicinal plants
From the themed collection: Drug design and discovery
Open Access Paper

Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents

The synthetic efficacy and biological relevance extend an opportunity to further drug-discovery development of fluoro-spiro-isoxazolines as novel anti-viral and anti-cancer agents.

Graphical abstract: Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents
From the themed collection: Drug design and discovery
Open Access Paper

Discovery of new acetylcholinesterase and butyrylcholinesterase inhibitors through structure-based virtual screening

Small molecule cholinesterase (ChE) inhibitors represent one of the most effective therapeutic strategies for the treatment of Alzheimer's disease (AD).

Graphical abstract: Discovery of new acetylcholinesterase and butyrylcholinesterase inhibitors through structure-based virtual screening
From the themed collection: Drug design and discovery
Paper

Inhibition of chikungunya virus replication by hesperetin and naringenin

Chikungunya virus (CHIKV) is an emerging arbovirus, which has recently become globally important.

Graphical abstract: Inhibition of chikungunya virus replication by hesperetin and naringenin
From the themed collection: Drug design and discovery
Paper

Synthesis, DNA/protein binding, molecular docking, DNA cleavage and in vitro anticancer activity of nickel(II) bis(thiosemicarbazone) complexes

Cytotoxic nickel(II) complexes with an N-substituted isatin thiosemicarbazone were synthesized and their interaction with CT DNA and BSA protein was investigated, which was supported by molecular docking studies.

Graphical abstract: Synthesis, DNA/protein binding, molecular docking, DNA cleavage and in vitro anticancer activity of nickel(ii) bis(thiosemicarbazone) complexes
From the themed collection: Drug design and discovery
Paper

Anticancer metallodrugs of glutamic acid sulphonamides: in silico, DNA binding, hemolysis and anticancer studies

In response to an increased demand for effective anticancer drugs, a series of disodium sulphonamides of L-glutamic acid (L1–L3) was synthesized. Sulphonamides were complexed with copper(II), nickel(II) and ruthenium(III) ions, separately and respectively.

Graphical abstract: Anticancer metallodrugs of glutamic acid sulphonamides: in silico, DNA binding, hemolysis and anticancer studies
From the themed collection: Drug design and discovery
21 items

About this collection

We are very pleased to present our 10th Anniversary collection on Drug design and discovery!

Looking back over the last 10 years, we would like to showcase some of the very best articles that have been published in RSC Advances. Many of these papers have been cited hundreds of times, providing valuable advances for further research, and some continue to be among the journal’s most downloaded articles as of today.

We hope you enjoy our 10th Anniversary collection on Drug design and discovery!

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