Themed collection Drug design and discovery
CuAAC-ensembled 1,2,3-triazole-linked isosteres as pharmacophores in drug discovery: review
The review lays emphasis on the significance of 1,2,3-triazoles synthesized via CuAAC reaction having potential to act as anti-microbial, anti-cancer, anti-viral, anti-inflammatory, anti-tuberculosis, anti-diabetic, and anti-Alzheimer drugs.
Natural source, bioactivity and synthesis of benzofuran derivatives
Benzofuran compounds are a class of compounds that are ubiquitous in nature.
Recent developments in the synthesis and biological activity of acridine/acridone analogues
Many people in the world struggle with cancer or bacterial, parasitic, viral, Alzheimer's and other diseases.
Two decades of new drug discovery and development for Alzheimer's disease
Alzheimer's disease is a progressive and irreversible neurodegenerative disease, associated with a decreased cognitive function and severe behavioral abnormalities.
Coumarin–chalcone hybrids: promising agents with diverse pharmacological properties
Coumarin–chalcone hybrid is an interesting template for medicinal chemists to develop therapeutic agents with diverse pharmacological activity.
Selected organophosphorus compounds with biological activity. Applications in medicine
The purpose of this article is to provide an overview of the latest applications of organophosphorus compounds (OPs) that exhibit biological activity.
Benzofuran: an emerging scaffold for antimicrobial agents
The present article systematically gives a comprehensive review of current development of benzofuran-based compounds as antimicrobial agents and the perspectives that they hold for future research.
Antileishmanial drug discovery: comprehensive review of the last 10 years
This review covers the current aspects of leishmaniasis including marketed drugs, new antileishmanial agents, and possible drug targets of antileishmanial agents.
Understanding cancer and the anticancer activities of naphthoquinones – a review
Naphthoquinone moieties are present in drugs such as doxorubicin which are used clinically to treat solid cancers.
Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics
Pyrrole is widely known as a biologically active scaffold which possesses a diverse nature of activities.
ortho-Quinone methide (o-QM): a highly reactive, ephemeral and versatile intermediate in organic synthesis
In this critical review, we provide a comprehensive view of the chemistry of ortho-quinone methides as versatile reactive intermediates in organic synthesis.
Importance and synthesis of benzannulated medium-sized and macrocyclic rings (BMRs)
Cyclic molecular frameworks, especially the benzannulated medium-sized and macrocyclic ring (BMR) systems, constitute an integral component of a large number of biologically significant natural or synthetic molecules.
Biologically active isoquinoline alkaloids with drug-like properties from the genus Corydalis
Corydalis plants are rich sources of isoquinoline alkaloids with various biological activities as well as drug-like properties.
Recent developments in solvent-free multicomponent reactions: a perfect synergy for eco-compatible organic synthesis
This review reports the development of multicomponent reactions over the last 10 years.
Re-evaluation of the N-terminal substitution and the D-residues of teixobactin
Teixobactin is a head to side-chain cyclic depsipeptide with a guanidino based residue within the cycle, three D-amino acids in the tail, and a N-methylated terminal residue.
DiaNat-DB: a molecular database of antidiabetic compounds from medicinal plants
Medicinal plants are widely used against diabetes mellitus. Here, we provide DiaNat-DB, the first publicly available database of secondary metabolites from medicinal plants, chemically characterized, and integrated with antidiabetic activity.
Synthesis and biological evaluation of fluoro-substituted spiro-isoxazolines as potential anti-viral and anti-cancer agents
The synthetic efficacy and biological relevance extend an opportunity to further drug-discovery development of fluoro-spiro-isoxazolines as novel anti-viral and anti-cancer agents.
Discovery of new acetylcholinesterase and butyrylcholinesterase inhibitors through structure-based virtual screening
Small molecule cholinesterase (ChE) inhibitors represent one of the most effective therapeutic strategies for the treatment of Alzheimer's disease (AD).
Inhibition of chikungunya virus replication by hesperetin and naringenin
Chikungunya virus (CHIKV) is an emerging arbovirus, which has recently become globally important.
Synthesis, DNA/protein binding, molecular docking, DNA cleavage and in vitro anticancer activity of nickel(II) bis(thiosemicarbazone) complexes
Cytotoxic nickel(II) complexes with an N-substituted isatin thiosemicarbazone were synthesized and their interaction with CT DNA and BSA protein was investigated, which was supported by molecular docking studies.
Anticancer metallodrugs of glutamic acid sulphonamides: in silico, DNA binding, hemolysis and anticancer studies
In response to an increased demand for effective anticancer drugs, a series of disodium sulphonamides of L-glutamic acid (L1–L3) was synthesized. Sulphonamides were complexed with copper(II), nickel(II) and ruthenium(III) ions, separately and respectively.
About this collectionWe are very pleased to present our 10th Anniversary collection on Drug design and discovery!
Looking back over the last 10 years, we would like to showcase some of the very best articles that have been published in RSC Advances. Many of these papers have been cited hundreds of times, providing valuable advances for further research, and some continue to be among the journal’s most downloaded articles as of today.
We hope you enjoy our 10th Anniversary collection on Drug design and discovery!