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Issue 99, 2014
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ortho-Quinone methide (o-QM): a highly reactive, ephemeral and versatile intermediate in organic synthesis

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Abstract

Since its first observation in 1907, ortho-quinone methide (o-QM) has occupied a strategic place within the framework of reactive intermediates in organic synthesis. In recent years, o-QM has enhanced its importance as a versatile reactive intermediate, and its applications in organic synthesis, material chemistry, fine chemicals, and pharmaceuticals are increasing rapidly. This critical review summarizes the key concepts behind o-QMs and provides an overview of current applications in organic synthesis to provide an appropriate background for synthetic, medicinal and combinatorial developments. This review covers the literature from its origin to the mid of 2014 (112 references).

Graphical abstract: ortho-Quinone methide (o-QM): a highly reactive, ephemeral and versatile intermediate in organic synthesis

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Article information


Submitted
24 Jun 2014
Accepted
07 Oct 2014
First published
07 Oct 2014

RSC Adv., 2014,4, 55924-55959
Article type
Review Article
Author version available

ortho-Quinone methide (o-QM): a highly reactive, ephemeral and versatile intermediate in organic synthesis

M. S. Singh, A. Nagaraju, N. Anand and S. Chowdhury, RSC Adv., 2014, 4, 55924
DOI: 10.1039/C4RA11444B

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