Issue 41, 2015

Antileishmanial drug discovery: comprehensive review of the last 10 years

Abstract

Leishmaniasis, a group of diseases caused by hemoflagellate obligate intracellular protozoa (trypanosomatids) from the genus Leishmania, has not received the attention it deserves and has developed into a major health problem in developing countries. No effective vaccine is available against leishmaniasis, so chemotherapy is the only effective way to treat all forms of the disease. However, the drugs currently used for treatment of human cutaneous and visceral leishmaniasis are toxic, having severe adverse reactions which limit their use. Therefore, development of novel, effective, and safe antileishmanial agents, with reduced side effects, is a major priority for health researchers, and large numbers of research reports have been published on antileishmanial agents in the last 10 years. Herein, we comprehensively review the developments of the last decade, covering all aspects of leishmaniasis including clinically used drugs, various new classes of antileishmanial agents (synthetic as well as natural), patented antileishmanial agents, and possible drug targets.

Graphical abstract: Antileishmanial drug discovery: comprehensive review of the last 10 years

Article information

Article type
Review Article
Submitted
11 Feb 2015
Accepted
18 Mar 2015
First published
19 Mar 2015

RSC Adv., 2015,5, 32376-32415

Antileishmanial drug discovery: comprehensive review of the last 10 years

J. N. Sangshetti, F. A. Kalam Khan, A. A. Kulkarni, R. Arote and R. H. Patil, RSC Adv., 2015, 5, 32376 DOI: 10.1039/C5RA02669E

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