Themed collection 2023 RSC Advances Popular Advances Collection

Self-healing polymers (SHPs) garner significant interest for their nature-inspired ability to regenerate surfaces, enhancing material durability and sustainability. This review highlights recent advances in SHPs, emphasizing scratch-regenerating technology, testing methods, and prospects.

Halichlorine and pinnaic acids are structurally related to natural alkaloids isolated from different marine organisms. This review summarizes the asymmetric synthesis strategies of halichlorine and pinnaic acid using a 6-azaspiro[4.5]decane skeleton as the key intermediate.

Cancer is the second most high-morbidity disease throughout the world.

The discovery and valorization of the unique homogeneous linear catechyl lignin (C-lignin) are systematically summarized.

Urease is produced by some bacteria and fungi, and its inhibition has been of interest as a potential therapeutic strategy for the treatment of certain bacterial infections and urea-related disorders.

A novel Cu(II)-acidic deep eutectic solvent was synthesized by the eco-friendly strategy and applied as multifunctional catalytic solvent system to furnish high yield of 1,2,3-triazoles in reducing agent- and base-free condition via CuAAC reaction.

The 4-MHA, a key node in the biosynthetic flow of actinomycins under NRPS catalysis, is also converted into actinrhaters A and B.

Bio-guided isolation was applied to Vietnamese Marchantia polymorpha L. to find alpha-glucosidase inhibition.

Eighteen isatin-based benzyloxybenzaldehyde derivatives from three subseries, ISB, ISFB, and ISBB, were synthesized and their ability to inhibit monoamine oxidase (MAO) was evaluated.

Herein, the promotional effects of Mg, Fe, and Pt on Ni-based catalysts supported on Al₂O₃-CeO₂ (Ni/Al₂O₃-CeO₂) were investigated in the dry reforming of methane (DRM) reaction.

In deep well drilling, the addition of functionalized additives into mud systems becomes imperative due to the adverse impact of elevated borehole temperatures and salts on conventional additives, causing them to compromise their intrinsic functionalities.

The paclitaxel-containing micelle bearing NO donor (NO/PTX) exhibited improved anticancer effect in Bel-7402 cells and H22 xenograft mice by the modes of ferroptosis, pyroptosis, ERS and apoptosis-associated networks.

Teucrium yemense (Defl.), a medicinal plant, grows in Yemen and Saudi Arabia and is also referred to as Reehal Fatima. The plant has a long history of use in these regions for the treatment of diabetes, rheumatism, and renal conditions.

A series of thiazoline and thiazolidinone-based 4-hydroxycoumarin derivatives were synthesized as anticancer agents using both conventional synthesis procedures and microwave-assisted techniques.

Anti-proliferative evaluation and in silico validation of synthesized substituted-3-hydroxy-2-oxindoles.

Pyrene-armed calix[4]arene conjugates non-covalently bind to DNA/RNA, as well as to mononucleotides, with an amazing affinity.

A series of 25 fluorescent conjugates sharing a common peptidic scaffold was developed for in vitro investigation of the multidrug resistant P-glycoprotein (P-gp) expression.

Bicyclic hydantoinothiolactone, as the key intermediate for production of (+)-biotin, has been efficiently and high-stereoselectively synthesized from the cheap starting material L-cystine via nine steps in 44% overall yield.

This study introduces novel coumarin–hydrazone hybrids, assessed for their potential as α-glucosidase inhibitors to treat diabetes. Compounds checked for α-glucosidase inhibition and in silico docking was also carried out. Studies suggest promising therapeutic significance and pharmaceutical use.

Four previously undescribed drimane sesquiterpenoids were isolated from cultures of the wood-inhabiting basidiomycete Dentipellis fragilis along with two other drimanes that were previously only known as synthetic or biotransformation products.

The gram-scale synthesis of benzofuranyl acetic acid via a Willgerodt–Kindler rearrangement is presented. Additionally, the antifungal activity against Fusarium oxysporum was tested for ten different benzofuranyl acetic acid amides.

A series of ten novel compounds were synthesized by incorporating a 1,3 thiazole core into amantadine and their structures were validated using different analytical and spectral methods such as FTIR, EI-MS, ¹H NMR, and ¹³C NMR.

The one-pot green synthesis of 1,4 dihydropyridines using nanostructured AlCl₃@ZnO under solvent-free ambient temperature conditions has been effectively accomplished. The proposed reaction protocol is sustainable, environmentally-friendly and offers economic viability.

The novel NIR photosensitizer, CyI-S-diCF₃, with excellent GSH consumption ability and ¹O₂ production efficiency, was successfully used for GSH depletion-assisted enhanced photodynamic therapy through disrupting redox homeostasis.

The modification of natural products is one of the key areas of synthetic organic chemistry for obtaining valuable chemical building blocks that have medicinal significance.

Sever blood lose in carcinogenic colorectal hemorrhage due to longitudinal ulcer, ultimately become fatal if left untreated.

A hybrid compound consisting of myricetin and nobiletin (MNH) was designed and synthesized, which might represent a protective effect against HUA via modulating the gut microbiota composition and serum metabolite profile.

For drug delivery applications, silica nanoemulsion encapsulated with organic compounds are becoming increasingly more desirable.

Isodon ternifolius (D.Don) Kudô is an important Asian herb used in traditional medicine against several diseases.

The objective of this study is to evaluate a series of molecules based on cyclosulfamide as potential anticancer agents.

New 2-oxo-chromene-7-oxymethylene acetohydrazide derivatives 4a–d were designed and synthesized with a variety of bioactive chemical fragments.

Through a redox reaction, Fe²⁺ was introduced into CoV₂O₆-NF and was transformed into high oxidation state Fe^(2+δ)+, acting as a partial active center to accelerate the OER process. CoV₂O₆-Fe-NF exhibited an overpotential of 298 mV at 100 mA cm⁻².

Graphical abstract of the study scheme indicatig Nigella sativa's promising inhibition of dengue virus enzymes.

New meroterpenoid derivative (austalide Z) isolated from the marine-derived fungal endophyte Aspergillus sp. with 9 known compounds. Cytotoxic evaluation of the isolated compounds against Caco-2 cell lines reveal weak to moderate activities.

A novel nano-graphene oxide supported ionic liquid/Fe (NGO/IL–Fe) is prepared, characterized and used as a powerful and highly recoverable nanocatalyst in the synthesis of tetrahydrobenzo[b]pyrans under green conditions.

Compound 19 arrested the MCF-7 cells at the G2/M phase probably through inhibition of CDK1 and elicited apoptosis. It did not violate Lipinski's rule of five and has a low blood brain barrier penetration and high intestinal absorption.

In an attempt to develop effective and safe antibacterial agents, thiazinanones bearing the quinolone scaffold were prepared by reaction of the corresponding (quinolinylmethylene)hydrazinecarbothioamides with 2,3-diphenylcycloprop-2-enone.

Protective effects of salazinic acid on male spermatogenic dysfunction in STZ-induced diabetic albino rats.

A novel and recyclable core–shell magnetic Ni^II-picolylamine/TCT/APTES@SiO₂@Fe₃O₄ with high specific area was introduced for the synthesis of pyridine derivatives.

Anchoring of Ni(II) complex onto the surface of mesoporous KIT-6 modified under mild reaction conditions as a highly efficient and reusable nanocatalyst for the synthesis of 5-substituted tetrazoles and pyranopyrazoles.

Centaurea scoparia flavonoids bind to the appropriate binding site on β-lactoglobulin via polar and hydrophobic interactions and bind to and inhibit xanthine oxidase.

A systematic study of the comparative performances of 4% Ga-, 4% Zr-, and 1% Cr-impregnated H-ZSM-5 catalysts for oxidative dehydrogenation of propane in the presence and absence of CO₂ is presented.

Central nervous system (CNS) diseases are a significant health burden globally, with the development of novel drugs lagging behind clinical needs.

The electrochemical behavior and sensing performance of an electrode modified with NiFe₂O₄ (NFO), MoS₂, and MoS₂–NFO were thoroughly investigated using CV, EIS, DPV, and CA measurements, respectively.

Toward finding potential and novel anticancer agents, we designed and prepared novel differently substituted unsymmetrical azine-modified thiadiazole sulfonamide derivatives using the “combi-targeting approach”.

Theoretical simulations reveal the general mechanism of antenna anchoring to the core in PSII.

An eco-friendly and efficient approach for the synthesis of 2-(1H-tetrazole-5-yl) acrylonitrile derivatives as the preferred product from raw materials through multicomponent domino reactions (MDRs) was introduced.

Calcination temperatures of 500, 625 and 750 °C were studied over a Ni/Al₃Fe₁ catalyst on glycerol valorization. The catalyst calcined at 625 °C showed the best performance due to its high activity and selectivity to 1,2-propanediol.

Two new triterpenes recurvatanes A and B were isolated from Mussaenda recurvata using bioactive-guided investigation.

Particles depicted in scanning electron micrographs are automatically identified and classified according to size and shape with a deep-learning algorithm. The procedure works for both SE images and STEM images.

Silica supported lanthanum trifluoroacetate and trichloroacetate as green Lewis acid catalysts were developed by a novel, simple, cheap, and environment friendly method and utilized them in the synthesis of arylimidazole derivatives via one pot solvent-free approach.

HIV-1 gp120 is the key component for viral entry through interaction with CD4 D1. The 5 best docking solutions were retained according to the docking scores. SD1 bound to gp120 at which 15 residues formed 20 hydrogen bonds with 16 residues of gp120.

Ethylene Oxide (EO) is an essential raw material used in various consumer products like different glycol derivatives, ethoxylates, and polymers.

Xanthine oxidase (XO) is a key target for gout treatment.

High-efficiency and durable V–Ti–Nb ternary catalyst prepared by a wet-solid mechanochemical method to enhance efficient condensation of HAc/HCHO to AA/MA.