Intramolecular Morita–Baylis–Hillman and Rauhut–Currier reactions. A catalytic and atom economic route for carbocycles and heterocycles
Intramolecular MBH and RC reactions: glorious past and future opportunities.
Recent advances in the application of deep eutectic solvents as sustainable media as well as catalysts in organic reactions
This review highlights the recent advances using deep eutectic solvents (DESs), deep eutectic ionic liquids (DEILs), low-melting mixtures (LMMs) or low transition temperature mixtures (LTTMs) as green media as well as catalysts in organic reactions.
New developments in direct functionalization of C–H and N–H bonds of purine bases via metal catalyzed cross-coupling reactions
This review provides a concise overview on the cross-coupling reactions in direct functionalization of purine bases in recent years.
Pyrrole: a resourceful small molecule in key medicinal hetero-aromatics
Pyrrole is widely known as a biologically active scaffold which possesses a diverse nature of activities.
A new C–C bond formation model based on the quantum chemical topology of electron density
Pseudodiradical structures and GEDT involved in the C–C single bond formation in non-polar, polar and ionic organic reactions.
Palladium-catalyzed Suzuki reaction in aqueous solvents applied to unprotected nucleosides and nucleotides
Nucleoside analogues have attracted much attention due to their potential biological activities.
Recent advances in 4(3H)-quinazolinone syntheses
The new routes and strategies for the synthesis of valuable 4(3H)-quinazolinones have been summarized.
Recent developments in palladium catalysed carbonylation reactions
Carbonylation reactions with a special emphasis on catalyst–product separation techniques are reviewed and discussed.
Recent development of direct asymmetric functionalization of inert C–H bonds
This review summarized recent development (contributions after 2009) in the area of direct catalytic asymmetric functionalization reactions of inert C–H bonds.
Understanding short-side-chain perfluorinated sulfonic acid and its application for high temperature polymer electrolyte membrane fuel cells
We summarize the properties of short-side-chain perfluorinated sulfonic acid membranes and provide insight into its micro-morphologies, mass diffusion and enhanced proton transportation.
Glutaraldehyde in bio-catalysts design: a useful crosslinker and a versatile tool in enzyme immobilization
Glutaraldehyde is one of the most widely used reagents in the design of biocatalysts.
Recent advances in the Cu(I)-catalyzed azide–alkyne cycloaddition: focus on functionally substituted azides and alkynes
The review is focused on synthetic applications of functionally substituted azides and terminal alkynes in the CuAAC combined with other transformations, such as multicomponent reactions, cross-coupling reactions, different cyclizations, etc.
Recent advances in transition-metal-free direct C–C and C–heteroatom bond forming reactions
This review highlights the progress in transition-metal-free carbon–carbon and carbon–heteroatom bond forming reactions, focusing on base and iodonium oxidant assisted inter- and intramolecular cross-couplings.
Base promoted direct C4-arylation of 4-substituted-pyrazolin-5-ones with diaryliodonium salts
A metal-free approach for the C4-arylation of 4-substituted-pyrazolin-5-ones with diaryliodonium salts was developed.
N-heterocyclic carbene-catalysed pentafluorophenylation of aldehydes
N-heterocyclic carbenes have been utilized as highly efficient organocatalysts to catalyse multifluorophenylation of aldehydes with fluorinated aryltrimethylsilanes to afford the corresponding adducts in 49–99% yields.
Synthesis of functionalized γ-lactones via a three-component cascade reaction catalyzed by consecutive N-heterocyclic carbene systems
Two consecutive N-heterocyclic carbene (NHC) catalytic systems were combined in a one-pot cascade reaction for the assembly of aromatic aldehydes and 2-haloenals into a structurally complex γ-lactone backbone.
Selective CO2 adsorption in a porphyrin polymer with benzimidazole linkages
A new nanoporous porphyrin-based benzimidazole linked polymer, PBILP, was synthesized.
A general route to 1,5-disubstituted 1,2,3-triazoles with alkyl/alkyl, alkyl/aryl, aryl/aryl combinations: a metal-free, regioselective, one-pot three component approach
An experimentally simple one-pot reaction, affording 1,5-disubstituted 1H-1,2,3-triazoles in good to excellent yields by combining vinyl sulfones, sodium azide and alkyl bromides, -tosylates, -mesylates or aryl amines, -iodides is reported.
L-Proline catalyzed multicomponent one-pot synthesis of gem-diheteroarylmethane derivatives using facile grinding operation under solvent-free conditions at room temperature
L-Proline catalyzed one-pot synthesis of gem-(β-dicarbonyl)-arylmethanes has been developed via a three-component reaction between indoles, aldehydes and C–H activated acids on grinding them together under solvent-free conditions at room temperature.
ConMedNP: a natural product library from Central African medicinal plants for drug discovery
Lipinski violations and compound distribution in ConMedNP by plant family of origin.
γ-valerolactone using a continuous-flow reactor
This study describes the heterogeneous catalysed continuous synthesis of γ-valerolactone (GVL) using a continuous-flow reactor, H-Cube® and H-Cube Pro™, equipped with 5% Ru/C, 10% Pd/C and RANEY® Ni CatCart®.
New generation biofuels:
γ-valerolactone into valeric esters in one pot
Copper supported on amorphous SiO2–ZrO2 was found to be an active catalyst for the one pot transformation of γ-valerolactone to ethyl and pentyl valerate.
Facile synthesis and photovoltaic applications of a new alkylated bismethano fullerene as electron acceptor for high open circuit voltage solar cells
In this work, a bis-adduct C60 derivative was facilely synthesized using an alkyl solubilizing group. This semiconductor offers a higher LUMO level compared to PCBM, which resulted in a significantly enhanced Voc of 0.73 V in organic solar cells.
Relevance of the acidic 1-butyl-3-methylimidazolium hydrogen sulphate ionic liquid in the selective catalysis of the biomass hemicellulose fraction
The process represents a sustainable and selective approach of biomass hemicellulose fraction transformation into pivot chemicals, such as xylose and furfural, solely mediated by the acidic [bmim][HSO4] ionic liquid.
Efficient adsorption of Europhtal onto activated carbon modified with ligands (1E,2E)-1,2-bis(pyridin-4-ylmethylene)hydrazine (M) and (1E,2E)-1,2-bis(pyridin-3-ylmethylene)hydrazine (SCH-4); response surface methodology
Porous activated carbon was modified with (1E,2E)-1,2-bis(pyridin-4-ylmethylene)hydrazine (M) and (1E,2E)-1,2-bis(pyridin-3-ylmethylene)hydrazine (SCH-4).
Speed versus stability – structure–activity effects on the assembly of two-component gels
Modifying the peripheral peptides dramatically changes the time required for gelation under ambient conditions, whilst an enthalpy–entropy balance means that as the temperature increases, the thermal stability of the gels is very similar.
Novel biodegradable poly(propylene fumarate)-co-poly(L-lactic acid) porous scaffolds fabricated by phase separation for tissue engineering applications
Three-dimensional polymer scaffolds with interconnected porous structures were fabricated by thermally induced phase separation of novel biodegradable poly(propylene fumarate)-co-poly(L-lactic acid).
Organocatalysis by p-sulfonic acid calixarene: a convenient and efficient route to 2,3-dihydroquinazolin-4(1H)-ones in water
An efficient and eco-friendly method is reported for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones using p-sulfonic acid calixarene as a recyclable organocatalyst in excellent yields in water at room temperature.
Deep eutectic solvent based on choline chloride and malonic acid as an efficient and reusable catalytic system for one-pot synthesis of functionalized pyrroles
Deep eutectic solvent (DES) based on choline chloride and malonic acid was applied as catalyst and reaction medium for synthesis of pyrroles by one-pot, four-component reaction of amines, aldehydes, 1,3-dicarbonyl compounds and nitromethane.
Hyperattenins A–I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy
Nine new bioactive polyprenylated acylphloroglucinols were isolated from the aerial parts of Hypericum attenuatum Choisy.
Can elongation of the π-system in triarylamine derived sensitizers with either benzothiadiazole and/or ortho-fluorophenyl moieties enrich their light harvesting efficiency? – a theoretical study
This study established that elongation of the π-system in a series of hypothetical triphenylamine dyes by the judicious placement either a fluorophenyl or benzothiadiazole group, or a combination of both groups, results in improved light harvesting efficiency in DSSCs.
Benzimidazolin-2-ylidene N-heterocyclic carbene complexes of ruthenium as a simple catalyst for the N-alkylation of amines using alcohols and diols
Simple non-chelating ruthenium benzimidazolin-2-ylidene complexes as efficient N-alkylation catalysts using alcohols and diols following a hydrogen borrowing strategy.
Magnesium complexes bearing N,N-bidentate phenanthrene derivatives for the stereoselective ring-opening polymerization of rac-lactides
Magnesium complexes based on N,N-bidentate phenanthrene derivatives derived from Schiff bases were synthesized and investigated as catalysts for rac-lactide polymerization.
Journey on greener pathways: use of Euphorbia condylocarpa M. bieb as reductant and stabilizer for green synthesis of Au/Pd bimetallic nanoparticles as reusable catalysts in the Suzuki and Heck coupling reactions in water
This work reports on the green synthesis of Au/Pd bimetallic nanoparticles by using Euphorbia condylocarpa M. bieb root extract and their application as separable catalysts for ligand-free Suzuki and Heck coupling reactions in water.
Biodiesel production, characterization, engine performance, and emission characteristics of Malaysian Alexandrian laurel oil
This article studies the production and characterization of Malaysian Alexandrian laurel oil and the effect of common blends on engine performance and emissions.
Production of γ-valerolactone from biomass-derived compounds using formic acid as a hydrogen source over supported metal catalysts in water solvent
Au/ZrO2 is a reusable and acid-tolerant catalyst for production of γ-valerolactone from biomass-derived compounds using formic acid as hydrogen source.
A near-infrared fluorescent sensor for selective detection of cysteine and its application in live cell imaging
We develop a NIR fluorescent sensor based on cyanine dyes for the selective detection of Cys.
Synthesis and characterization of novel bio-based benzoxazines from eugenol
Polybenzoxazines are phenolic-like materials that possess dimensional and thermal stability, and they release no by-products during their polymerization.
Cyclic 3-hydroxymelatonin, a key metabolite enhancing the peroxyl radical scavenging activity of melatonin
The peroxyl radical scavenging activity of cyclic 3-hydroxymelatonin (3-OHM) has been investigated and compared with that melatonin, AMK, AFMK, and Trolox. It is proposed that the protective effects of melatonin against peroxyl radicals become important after being metabolized into 3-OHM.
LDA-promoted asymmetric synthesis of β-trifluoromethyl-β-amino indanone derivatives with virtually complete stereochemical outcome
Reactions of 1-indanones and (SS)-N-tert-butanesulfinyl-(3,3,3)-trifluoroacetaldimine were developed, which used catalytic amounts of LDA with complete stereochemical outcome and excellent yields.
Imidazole as organocatalyst for multicomponent reactions: diversity oriented synthesis of functionalized hetero- and carbocycles using in situ-generated benzylidenemalononitrile derivatives
The multicomponent reaction of malononitrile, aldehyde and naphthol/4-hydroxycoumarine/2-hydroxynaphthoquinone/kojic acid/enolizable ketone or thiol in the presence of imidazole provides very interesting molecular diversity.
Oxidative synthesis of quinazolinones and benzothiadiazine 1,1-dioxides from 2-aminobenzamide and 2-aminobenzenesulfonamide with benzyl alcohols and aldehydes
An interesting procedure for the zinc-catalyzed oxidative transformation of ready available 2-aminobenzamide, 2-aminobenzenesulfonamide with benzyl alcohols has been developed.
About this collection
This collection is Guest Edited by Editorial Board Member Professor Russell Cox . It contains selected reviews, communications and full papers published from 2013 to 2015. The collection brings together articles with the continued aim of inspiring new authors to submit their best work to the journal, but also to highlight great work by regular authors. These articles are already among the most highly cited works in the journal, illustrating their impact. The subject areas include those traditionally regarded as organic, such as synthesis, catalysis, heterocyclic and organometallic chemistry, natural products chemistry and method development. In addition, it also includes articles from overlapping areas including green chemistry, fuel production, ionic solvents and materials chemistry, where there is a strong organic and biological component. Underpinning all are theoretical and computational studies. Finally, emerging areas such as photovoltaics and chemical biology have strong organic chemistry foundations and also find a natural home in this RSC Advances collection. Overall, this selection aims to illustrate the breadth, depth and impact of papers published in RSC Advances in the area of organic chemistry and stimulate new submissions in these and allied areas.