Metal interactions with nucleic acids
Welcome to the Dalton Transactions ‘metal interactions with nucleic acids’ themed issue.
Metal complex interactions with DNA
Increasing numbers of DNA structures are being revealed using a diverse range of transition metal complexes and biophysical spectroscopic techniques. Here we present a review of metal complex-DNA interactions in which several binding modes and DNA structural forms are explored.
Zinc complexes as fluorescent chemosensors for nucleic acids: new perspectives for a “boring” element
Recent applications of zinc(II) complexes as fluorescent probes for nucleic acids are described highlighting their potential as diagnostic tools.
Unprecedented dinuclear silver(I)-mediated base pair involving the DNA lesion 1,N6-ethenoadenine
For the first time, a dinuclear purine-based metal-mediated homo base pair has been incorporated into a B-DNA duplex.
Convenient detection of metal–DNA, metal–RNA, and metal–protein adducts with a click-modified Pt(II) complex
cis-[Pt(2-azido-1,3-propanediamine)Cl2] is a reagent for high-yield post-treatment fluorescent labelling of Pt(II) biomolecular targets using click chemistry and exhibits a bias in conformational isomers in the context of duplex DNA.
Antitumor properties of platinum(IV) prodrug-loaded silk fibroin nanoparticles
We have successfully generated silk nanoparticles loaded with the hydrophobic platinum(IV) antitumor prodrug PtBz achieving high cell selectivity factors.
Binding of an organo–osmium(II) anticancer complex to guanine and cytosine on DNA revealed by electron-based dissociations in high resolution Top–Down FT-ICR mass spectrometry
Binding of an organo–osmium anticancer complex not only to guanine but also cytosine on DNA is revealed by electron-detachment dissociation tandem MS.
Cobalt(III)porphyrin to target G-quadruplex DNA
A bulky cationic cobalt(III) porphyrin carrying two water molecules as axial ligands interacts in a π-stacking like mode with the 5′-external guanine quartet of G-quadruplex DNA.
Photoinduced interactions of two dirhodium complexes with d(GTCGAC)2 probed by 2D NOESY
2D 1H–1H NOESY reveals that irradiation of cis-H,H-[Rh2(HNOCCH3)2(dppz)(CH3CN)4]2+ results in covalent binding and end-capping of the complex to d(GTCGAC)2.
Redox-active and DNA-binding coordination complexes of clotrimazole
The coordination compounds bind to DNA by two different binding modes depending on the concentration, sequence of the DNA, and the structure of the complex.
Bifunctional Zn(II) complexes for recognition of non-canonical thymines in DNA bulges and G-quadruplexes
The aromatic pendent groups of Zn(II) tetraazamacrocyclic complexes were varied to study their role in the recognition of non-canonical thymines in a DNA bulge and in the human telomeric G-quadruplex.
Mono- and dinuclear metal complexes containing the 1,5,9-triazacyclododecane (aneN3) unit and their interaction with DNA
It takes two to tango: Only the dinuclear but not the mononuclear metal complexes of triazacyclododecane (aneN3) were able to induce the Z-DNA of poly d(GC).
Solution studies on DNA interactions of substitution-inert platinum complexes mediated via the phosphate clamp
NMR studies confirmed phosphate clamp–DNA binding in solution and the sequence dictates minor-groove spanning or backbone tracking.
Binding of copper(II) polypyridyl complexes to DNA and consequences for DNA-based asymmetric catalysis
Insight into the structure of DNA-based catalysts is obtained by elucidation of the DNA-binding mode of catalytically active copper complexes.
Characterisation of the interactions between substrate, copper(II) complex and DNA and their role in rate acceleration in DNA-based asymmetric catalysis
High effective molarity is responsible for the significant increase of binding of substrates to copper(II) complexes in DNA-based catalysis.
Interactions of selected gold(III) complexes with DNA G quadruplexes
The interactions of three Au(III) complexes with human telomeric DNA sequences: Auoxo6 turned out to be very effective in inducing and binding the G-quadruplex DNA conformation.
The induction of lysis in lysogenic strains of Escherichia coli by a new antitumor transplatin derivative and its DNA interactions
DNA is the cellular target for antitumor derivatives of transplatin including those containing small aliphatic amino ligands.
Competitive formation of DNA linkage isomers by a trinuclear platinum complex and the influence of pre-association
The trinuclear platinum drug BB3464 pre-associates in the minor groove at two different sites on a 14-mer duplex and this dictates the nature of the adducts formed in both 5′-5′ and 3′-3′ directions.
Protein ruthenation and DNA alkylation: chlorambucil-functionalized RAPTA complexes and their anticancer activity
The conjugation of chlorambucil to the RAPTA scaffold results in an anticancer active agent capable of cross-linking DNA and proteins.
Binding of Ru(terpyridine)(pyridine)dipyridophenazine to DNA studied with polarized spectroscopy and calorimetry
Achiral Ru(tpy)(py)dppz2+ intercalated into DNA has similar intermolecular interactions as opposite enantiomers of its structural isomer, the “light-switch” complex Ru(bpy)2dppz2+.
RNA and DNA binding of inert oligonuclear ruthenium(II) complexes in live eukaryotic cells
Oligonuclear polypyridylruthenium(II) complexes show selectivity for the nucleus of eukaryotic cells with a considerable preference for the RNA-rich nucleolus.
Syntheses of polypyridyl metal complexes and studies of their interaction with quadruplex DNA
A series of metal complexes with substituted terpyridines show high affinity towards quadruplex DNA, particularly bimetallic (trpy)Pt/M(cyclen) complexes.
Synthesis, cytotoxicity, DNA interaction and cell cycle studies of trans-diiodophosphine Pt(II) complexes
Diiodido phosphine Pt complexes were synthesized and their biological activity studied. The complex with isopropylamine was the best candidate.
DNA fragment conformations in adducts with Kiteplatin
The anticancer-active platinum complex with cis-1,4-diaminocyclohexane has proved to be very valuable in detecting multiple conformers in adducts with oligonucleotides.
About this collection
Guest edited by Professor Dr Jan Reedijk (Leiden University) and Professor Michael Hannon (University of Birmingham), this issue highlights a diverse number of topics within metal-nucleic acid chemistry.