Issue 8, 2015

Interactions of selected gold(iii) complexes with DNA G quadruplexes

Abstract

The interactions of three representative gold(III) complexes with human telomeric DNA sequences were analysed using a variety of biophysical methods, including DNA melting, circular dichroism, SPR and ESI MS; remarkable interactions were highlighted for all tested complexes, although they were associated to significantly different binding profiles. The most interesting compound was Auoxo6, a dinuclear gold(III) complex, which beyond manifesting a conspicuous binding affinity for the G-quadruplex conformation, turned out to be very effective in inducing a non-canonical secondary structure. These findings may clear the way for novel biological and pharmacological applications of this class of metal compounds.

Graphical abstract: Interactions of selected gold(iii) complexes with DNA G quadruplexes

Supplementary files

Article information

Article type
Paper
Submitted
03 Sep 2014
Accepted
12 Nov 2014
First published
13 Nov 2014

Dalton Trans., 2015,44, 3633-3639

Interactions of selected gold(III) complexes with DNA G quadruplexes

P. Gratteri, L. Massai, E. Michelucci, R. Rigo, L. Messori, M. A. Cinellu, C. Musetti, C. Sissi and C. Bazzicalupi, Dalton Trans., 2015, 44, 3633 DOI: 10.1039/C4DT02698E

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