Unprecedented dinuclear silver(i)-mediated base pair involving the DNA lesion 1,N6-ethenoadenine†
Abstract
The DNA lesion 1,N6-ethenoadenine (εA) has been investigated with respect to its metal-binding properties. A synthetic DNA duplex comprising an εA : εA mispair readily forms doubly silver(I)-mediated base pairs εA–Ag(I)2–εA, representing the first example for a dinuclear metal-mediated homo base pair of a purine derivative. It also constitutes the first example for a Hoogsteen-type metal-mediated homo base pair within a B-DNA duplex.
- This article is part of the themed collection: Metal Interactions with Nucleic Acids