Themed collection Most downloaded articles of 2017: Organic and Biological Chemistry

This feature article focuses on the use of carboxylic acids as traceless directing groups and the application of this concept to achieve regiochemical control in organic chemistry.

This feature article discusses the range of stereospecific transformations available to enantioenriched boronic esters, and their applications in synthesis.

This Feature Article presents and discusses the use of different methods to quantify and explore the steric impact of N-heterocyclic carbene (NHC) ligands.

This feature article gives an overview of sugar-based polymers that can be made by ring-opening-polymerisation and their applications.

This feature article presents the principles and most recent examples of organic molecules in which long lived and highly intense room-temperature phosphorescence is switched on by rigidification of the matrix in a crystal or in a polymer or by interaction with other molecules.

This article reports the synthesis of fully arylated (hetero)arenes and categorizes this emerging topic by the type of (hetero)arene core and the type of chemistry employed to install the (hetero)aryl substituents.

We discuss the properties and potential future applications in catalysis, sensing and materials of ligands based on mechanically interlocked molecules.

A modular synthetic approach was developed that yielded thirty diverse lead-like scaffolds suitable for CNS drug discovery.

Core–shell structured Fe₃O₄@COFs were synthesized and used as a new absorbent for efficient enrichment of peptides and simultaneous exclusion of proteins.

Four novel bis-boronic acid compounds were synthesised via copper catalysed azide–alkyne cycloaddition (CuAAC) reactions.

We report the first examples of the simultaneous non-assisted replacement of ligands and the conversion of topology in MOFs by applying the PSM approach.

The inverse-electron demand Diels–Alder (IEDDA) click reaction between thiocarbamate-functionalized trans-cyclooctenes and tetrazines provides a new strategy for bio-orthogonal COS/H₂S delivery.

A multifunctional, solution processable, ultramicroporous polymer employed for white light emission in solution, nanoparticles, a gel and a transparent thin film.

A green one-pot hydrothermal route quantitatively generates high-purity fluorescence bisimide dyes without the need for catalysts or organic solvents.

The general coupling of amine/ether C(sp³)–H bonds with alkenyl/(hetero)aryl C–O electrophiles is reported with high selectivity.

In this study, we have developed a catalyst-free N-methylation of amines to prepare numerous methylamines using CO₂ as a methyl source, utilizing 2 eq. PhSiH₃ as the reductant.