Jump to main content
Jump to site search

Issue 41, 2017
Previous Article Next Article

The use of carboxylic acids as traceless directing groups for regioselective C–H bond functionalisation

Author affiliations

Abstract

The ability to selectively functionalise a specific C–H bond is a long-standing challenge due to the ubiquity of such bonds in organic molecules. One of the most common approaches to overcome this obstacle consists of installing directing groups into substrates to direct the functionalisation towards the desired C–H bond, leaving behind the directing group in the molecule. Alternatively, carboxylic acids have been employed as traceless directing groups that are easily removed after carboxylic acid-directed installation of the desired functionality. This review focuses on the development of this concept and its application to organic synthesis during the last decade.

Graphical abstract: The use of carboxylic acids as traceless directing groups for regioselective C–H bond functionalisation

Back to tab navigation

Article information


Submitted
07 Mar 2017
Accepted
28 Apr 2017
First published
28 Apr 2017

This article is Open Access

Chem. Commun., 2017,53, 5584-5597
Article type
Feature Article

The use of carboxylic acids as traceless directing groups for regioselective C–H bond functionalisation

M. Font, J. M. Quibell, G. J. P. Perry and I. Larrosa, Chem. Commun., 2017, 53, 5584
DOI: 10.1039/C7CC01755C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements