Themed collection In celebration of Chinese New Year

In this perspective, we discuss the challenges, advances and opportunities in electroanalytical chemistry at nanoelectrodes, including nanoelectrode fabrication, real-time characterizations, and high-performance electrochemical instrumentation.

We reviewed recent advances in telomerase assays including both in vitro detection and in vivo imaging.

A ratiometric two-photon probe was designed to visualize HClO levels in tissues, revealing the generation of HClO in the wound-repairing process of mice for the first time.

A 2D nano-reactor was constructed within a pillar–layer-MOF, in which a moderately stable 2D phosphorus material was synthesized.

White-light emission from a single molecule was realized and tuned via multistimuli including excitation, solvent polarity, temperature and host–guest interactions.

A pre-protective strategy for precise tumor targeting and efficient photodynamic therapy was developed using a switchable DNA/upconversion nanocomposite.

We developed a novel strategy for enhanced radiation therapy based on a mitochondria targeted titanium dioxide-gold nanoradiosensitizer.

This article investigates structures of ionic liquids.

We develop a single quantum dot (QD)-based nanosensor for sensitive detection of DNA methylation at both CpG and non-CpG sites.

Here we report a chemical strategy that uses rigid molecules to straightforwardly construct amphiphilic carbon dots (ACDs) with high luminescence quantum yields (QYs).

We demonstrate the simultaneous detection of human 8-oxoguanine DNA glycosylase 1 and human alkyladenine DNA glycosylase at the single-molecule level.

The doping of Pd with a small amount of Te can selectively convert CO₂ to CO with a low overpotential.

We report a unified photoredox-catalysis strategy for both hydroxylation and amidation of tertiary and benzylic C–H bonds.

The first total syntheses of schilancidilactones A and B, schilancitrilactone A, and 20-epi-schilancitrilactone A have been accomplished.

A new class of highly luminescent bis(alkynyl)gold(III) N⁁C complexes has been utilized as emissive materials in OLEDs and exhibits mechanochromic behaviors.

We have developed a new fluorescent and photoacoustic dual-mode probe, ER-P, for the detection of ER polarity of liver tissues in normal and diabetic mice.

A hetero[6]rotaxane bearing three different kinds of macrocycle is designed and successfully synthesized through a one-pot “click” reaction by employing a facile and efficient integrative self-sorting principle.

A powerful material discovery tool is invented by combining SSW global optimization with neural network computing, which identifies unprecedented TiO₂ phases.

We demonstrate a sensitive, easy and fast method for the fluorometric probing of the lipase level as acute pancreatitis biomarkers based on the novel interfacially controlled aggregation-induced emission (AIE) mechanism.

This work describes a facile yet powerful approach to energy-transfer NMOF (nanoscale metal–organic framework) fabrication for ratiometric peroxynitrite (ONOO⁻) sensing.

Flavoenzymes are ubiquitous in biological systems and catalyze a diverse range of chemical transformations.

An alpha-cyclodextrin (α-CD)-based gold/DNA nanomachine was developed as a novel theranostic agent for tumor-selective diagnosis and therapy.

An N-nitrosation reactivity-based two-photon fluorescent probe for the specific detection of NO was rationally designed, prepared, and applied in the in situ detection of nitric oxide in ischemia reperfusion injury mouse model under two-photon microscopy for the first time.

An integrative metalloproteomic approach to unveil the role of antimicrobial metals in general using bismuth as an example.

The present study described bipyridine-based organosilica nanotubes with ∼50 nm length; these nanotubes provide highly active and robust molecular iridium heterogeneous catalysts for C–H oxidation of heterocycles and cycloalkanes as well as C–H borylation of arenes.

A new class of platinum(II) terpyridine complexes with a phosphole-derived bridging alkynyl ligand have been prepared.

A peroxynitrite-specific two-photon fluorescent probe was developed for revealing drug-induced hepatotoxicity using peroxynitrite as a biomarker.

A nuclear-targeted siRNA delivery system was developed for long-term gene silencing in cancer cells. The nanocarrier consists of gold nanoparticles, synthetic siRNAs and nuclear localization signal peptides.

We demonstrated contact electrification induced interfacial redox reactions and developed a direct electrochemical nanoimprint lithography method applicable to crystalline semiconductors.

POSS-functionalized platinum(II) complexes demonstrate systematically controllable morphological transformations through interplay of intermolecular interactions.

We report experiments and simulations demonstrating that multiple distinct motion trajectories of individual nanoparticles can be discerned from time-resolved current traces.

Cosensitization of two dyes with different molecular sizes and photovoltaic characteristics is demonstrated to successfully prevent the “trade-off” effect, leading to an excellent power-conversion efficiency of 10.09% under one-sun and 11.12% under 0.3 sun 4 irradiation.

Direct attachment of a photoactive bis-thienyl unit to benzo[b]phosphole oxide has led to a new photochromic compound that shows excellent performance in ambient thin film conditions.

Water rotational dynamics in NaSCN and KSCN solutions at a series of concentrations are investigated using femtosecond infrared spectroscopy and theory.

Dual modulated luminescence of carbogenic nanodots derived from zeolites has been acquired by controlling the concentration and pH value of CND aqueous dispersions.