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Issue 12, 2018
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A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy

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Abstract

Radiation therapy (RT) has been widely used for malignant tumor treatment. However, the large dosage of ionizing radiation and high frequency of radiotherapy in clinical cancer therapy cause severe damage to normal tissues adjacent to tumors. Therefore, how to increase the local treatment efficacy and reduce the damage to normal tissues has been a challenge for RT. Herein, we developed a novel strategy for enhanced RT based on a mitochondria targeted titanium dioxide-gold nanoradiosensitizer. When irradiated with X-rays, the nanosensitizer could produce reactive oxygen species (ROS) in the mitochondria, which induced the domino effect on the ROS burst. The overproduced ROS accumulated in mitochondria, resulting in mitochondrial collapse and irreversible cell apoptosis. A colony formation assay indicated that the cell survival rate when incubated with the mitochondrial targeted nanosensitizer was significantly lower than that of non-targeted groups. As demonstrated by in vivo experiments, the tumor was significantly suppressed even just once RT with the nanosensitizer.

Graphical abstract: A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy

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Publication details

The article was received on 15 Oct 2017, accepted on 06 Feb 2018 and first published on 28 Feb 2018


Article type: Edge Article
DOI: 10.1039/C7SC04458E
Citation: Chem. Sci., 2018,9, 3159-3164
  • Open access: Creative Commons BY license
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    A mitochondria-targeted nanoradiosensitizer activating reactive oxygen species burst for enhanced radiation therapy

    N. Li, L. Yu, J. Wang, X. Gao, Y. Chen, W. Pan and B. Tang, Chem. Sci., 2018, 9, 3159
    DOI: 10.1039/C7SC04458E

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