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Issue 4, 2017
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Sensing telomerase: From in vitro detection to in vivo imaging

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Abstract

Telomerase is a ribonucleoprotein reverse transcriptase that is responsible for maintaining the telomere length in cells. Telomerase overexpresses in almost all malignant tumor cells, and it has become a promising biomarker and a potential therapy target for cancers. Consequently, accurate and efficient quantification of the telomerase is highly essential to medical diagnostics and therapeutics. Recently, a series of novel telomerase detection methods with excellent performance have been developed, but a overview of in vivo telomerase detection methods is lacking. In this Minireview, we summarize the emerging strategies for telomerase assays in the last five years, including both in vitro assays and in vivo imaging methods, and discuss their future directions as well.

Graphical abstract: Sensing telomerase: From in vitro detection to in vivo imaging

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Publication details

The article was received on 28 Oct 2016, accepted on 12 Dec 2016 and first published on 13 Dec 2016


Article type: Minireview
DOI: 10.1039/C6SC04801C
Citation: Chem. Sci., 2017,8, 2495-2502
  • Open access: Creative Commons BY license
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    Sensing telomerase: From in vitro detection to in vivo imaging

    L. Wang, F. Ma, B. Tang and C. Zhang, Chem. Sci., 2017, 8, 2495
    DOI: 10.1039/C6SC04801C

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