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Nanoscale metal-organic frameworks coated with poly(vinyl alcohol) for ratiometric peroxynitrite sensing through FRET

Abstract

This work describes a facile yet powerful approach to energy-transfer NMOF(Nanoscale metal-organic framework) for ratiometric peroxynitrite (ONOO-) sensing. Poly(vinyl alcohol)(PVA) is chosen to organize energy donor (NMOF) and acceptor (molecular probes). PVA can conveniently graft onto NMOF surface and bind to the molecular probes that bearing with arylboronic acid group through multiple weak coordination interactions. Due to efficient Förster resonance energy transfer (FRET), the bright blue fluorescence of NMOF is quenched while green or red emission from acceptor is enhanced. Upon reacting with ONOO-, the ONOO- sensors depart from NMOF and the FRET is interrupted and the fluorescence of NMOF recovered. Based on this strategy, we developed two ratiometric ONOO- nanosensors for the detection of ONOO- in solutions and living cells. This work is the first report of NMOF ONOO- sensors through FRET and could inspire the design of other NMOF based chemical sensors and biosensors.

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Publication details

The article was received on 09 Mar 2017, accepted on 08 May 2017 and first published on 18 May 2017


Article type: Edge Article
DOI: 10.1039/C7SC01077J
Citation: Chem. Sci., 2017, Accepted Manuscript
  • Open access: Creative Commons BY license
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    Nanoscale metal-organic frameworks coated with poly(vinyl alcohol) for ratiometric peroxynitrite sensing through FRET

    Z. Ding, J. Tan, G. Feng, Z. Yuan, C. Wu and X. Zhang, Chem. Sci., 2017, Accepted Manuscript , DOI: 10.1039/C7SC01077J

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