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Issue 7, 2017
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Nanoscale metal–organic frameworks coated with poly(vinyl alcohol) for ratiometric peroxynitrite sensing through FRET

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Abstract

This work describes a facile yet powerful approach to energy-transfer NMOF (nanoscale metal–organic framework) fabrication for ratiometric peroxynitrite (ONOO) sensing. Poly(vinyl alcohol) (PVA) is chosen to organize the energy donor (NMOF) and acceptor (molecular probes). PVA can conveniently graft onto the NMOF surface and bind to the molecular probes bearing the arylboronic acid group through multiple weak coordination interactions. Due to efficient Förster resonance energy transfer (FRET), the bright blue fluorescence of the NMOF is quenched while the green or red emission from the acceptor is enhanced. Upon reacting with ONOO, the ONOO sensors depart from the NMOF and the FRET is interrupted and the fluorescence of the NMOF recovered. Based on this strategy, we developed two ratiometric ONOO nanosensors for the detection of ONOO in solutions and living cells. This work is the first report of NMOF ONOO sensors through FRET and could inspire the design of other NMOF based chemical sensors and biosensors.

Graphical abstract: Nanoscale metal–organic frameworks coated with poly(vinyl alcohol) for ratiometric peroxynitrite sensing through FRET

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Publication details

The article was received on 09 Mar 2017, accepted on 08 May 2017 and first published on 18 May 2017


Article type: Edge Article
DOI: 10.1039/C7SC01077J
Citation: Chem. Sci., 2017,8, 5101-5106
  • Open access: Creative Commons BY license
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    Nanoscale metal–organic frameworks coated with poly(vinyl alcohol) for ratiometric peroxynitrite sensing through FRET

    Z. Ding, J. Tan, G. Feng, Z. Yuan, C. Wu and X. Zhang, Chem. Sci., 2017, 8, 5101
    DOI: 10.1039/C7SC01077J

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