Themed collection Wearable and Implantable Sensors

There has been an emerging interest in the development of microfluidic wearable technologies, arising from increasing demands in the areas of healthcare.

Emerging wearable and implantable biodevices with shape-adaptable capabilities have been significantly revolutionizing the diagnosis and treatment of disease.

Tasoglu, Yetisen and co-workers review the emerging medical and health-related applications of optical fibers, illustrating the new wave for the fabrication of implantable devices, wearable sensors, and photodetection and therapy setups.

Flexible biosensors represent an increasingly important and rapidly developing field of research.

Non-invasive wearable sensing technology extracts mechanical, electrical, optical, and chemical information from the human body.

PDMS thin-film transfer and enzyme microstamping enabled 3-in-1 Si/PDMS hybrid chemtrode for multi-analyte sensing and chemical delivery in vivo.

For microfluidic applications, we propose a nanochannel for easy fabrication and integration, which is capable of an easy transition between the 3 regimes on demand. We demonstrated an ionic diode and pre-concentration/sensing of DNA.

This work presents a wearable electrofluidic actuation system, which exploits the alternating current electrothermal (ACET) effects to engineer biofluid flow profiles on the body.

The applications of optical fibers are impeded in implantable medical diagnostics due to incompatibility with biological tissues, and immune reaction in vivo.

We present a hybrid-flex wearable system to autonomously analyze sweat—induced at programmable secretion rates—for diurnal biomarker data acquisition.

Wearable bioelectronic systems are one of the most important tools for human health and motion monitoring.

Soft, skin-interfaced microfluidic platforms are capable of capturing, storing, and assessing sweat chemistry and total sweat loss, which provides essential insight into human physiological health.

SLOCK is a sweat based platform for monitoring circadian relevant biomarkers-cortisol and DHEA, using electrochemical detection modality.

Control of molecular diffusion through nanofluidic channels using electrostatic gating.

A rapid and cost-effective method for monitoring proteins in tear-fluid is reported, which enables biomarker monitoring using contact lenses toward personalized mobile-health applications.

On-chip digital microfluidic flowmetry can be designed and incorporated into standard microfluidic devices for high-precision multiplexed microflow measurements.

A liquid metal-based soft sensor for droplet detection and evaluation in flexible microchannels.

Presented is an ultra-simple wearable local sweat volume monitoring patch based on swellable hydrogels.

Soft microfluidics with reference reactions enable quantitative sweat ammonia–ethanol assay.

The all-fluidic low-pass filtering feature of dilatometric strain sensors has the potential to suppress physiological noise.

Point-of-care (POC) diagnostics have shown excellent potential in rapid biological analysis and health/disease monitoring.

A wearable, multi-modal sensing patch for sweat rate and electrolyte analysis with inbuilt cross-verification schemes to ensure data integrity.

We devise a simple, scalable, and low-cost “CAD-to-3D Device” fabrication and integration scheme, which renders 3D and complex microfluidic architectures for wearable biofluid sampling, manipulation, and sensing.

An implantable nanofluidic device for remote controlled drug delivery.

Passive sweat collection and colorimetric analysis.

Combining experimental and theoretical approach, we demonstrate practical solutions to limiting currents in capillary-based electrophoretic delivery devices.

A PDMS-based handy microsensor for on-chip microscale integrable pressure monitoring with high resolution.

A digital flowmetry sensor is fabricated with low limit of detection and wide dynamic range, that is suitable for lab-on-chip or wearable sweat sensing systems.

A wearable sweat biosensing device is demonstrated that stimulates sweat and continuously measures sweat ethanol concentrations at 25 s intervals, which is then correlated with blood ethanol during a >3 hour testing phase.

A novel flexible enzyme-electrode sensor was fabricated with a big cylindrical working electrode which, cooperating with the surface-modified 3D nanostructure, significantly improved the sensitivity.

A passive wearable microfluidic sensor for the 24 hour monitoring of intraocular pressure using a smartphone.

Moving to ultra-low (<100 nL) sample volumes presents numerous challenges, many of which can be resolved by implementation of open nanofluidic films.

Implementation of wearable sweat sensors for continuous measurement of fluid based biochemical markers is an attractive alternative to common, yet intrusive and invasive, practices such as urine or blood analysis.

A wearable microfluidic system and smartphone optics module enabled in situ analysis of sweat.

We developed a wearable tactile sensor using flexible microfluidics. This liquid-based sensor is thin, flexible and sensitive enough to be mounted on the skin or embedded in a fabric glove to detect tactile forces.