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An autonomous wearable system for diurnal sweat biomarker data acquisition

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Abstract

To track dynamically varying and physiologically relevant biomarker profiles in sweat, autonomous wearable platforms are required to periodically sample and analyze sweat with minimal or no user intervention. Previously reported sweat sensors are functionally limited to capturing biomarker information at one time-point/period, thereby necessitating repeated user intervention to increase the temporal granularity of biomarker data. Accordingly, we present a compact multi-compartment wearable system, where each compartment can be activated to autonomously induce/modulate sweat secretion (via iontophoretic actuation) and analyze sweat at set time points. This system was developed following a hybrid-flex design and a vertical integration scheme—integrating the required functional modules: miniaturized iontophoresis interfaces, adhesive thin film microfluidic-sensing module, and control/readout electronics. The system was deployed in a human subject study to track the diurnal variation of sweat glucose levels in relation to the daily food intake. The demonstrated autonomous operation for diurnal sweat biomarker data acquisition illustrates the system's suitability for large-scale and longitudinal personal health monitoring applications.

Graphical abstract: An autonomous wearable system for diurnal sweat biomarker data acquisition

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Supplementary files

Article information


Submitted
13 Aug 2020
Accepted
06 Oct 2020
First published
07 Oct 2020

Lab Chip, 2020, Advance Article
Article type
Paper

An autonomous wearable system for diurnal sweat biomarker data acquisition

H. Hojaiji, Y. Zhao, M. C. Gong, M. Mallajosyula, J. Tan, H. Lin, A. M. Hojaiji, S. Lin, C. Milla, A. M. Madni and S. Emaminejad, Lab Chip, 2020, Advance Article , DOI: 10.1039/D0LC00820F

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