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Open nanofluidic films with rapid transport and no analyte exchange for ultra-low sample volumes

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Abstract

Moving to ultra-low (<100 nL) sample volumes presents numerous challenges, many of which can be resolved by implementation of open nanofluidic films. These nanofluidic films are fabricated using a hexagonal network of gold-coated open microchannels which capture all of the following innovative advantages: (1) sample volumes of <100 nL cm−2; (2) zero analyte exchange and loss with the film materials; (3) rapid and omni-directional wicking transport of >500 nL min−1 per square of film; (4) ultra-simple roll-to-roll fabrication; (5) stable and bio-compatible super-hydrophilicity for weeks in air by peptide surface modification. Validation includes both detailed in vitro characterization and in vivo validation with sweat transport from the human skin. Sampling times (skin-to-sensor) of <3 min were achieved, setting new benchmarks for the field of wearable sweat sensing. This work addresses significant challenges for sweat biosensing, or for any other nano-liter regime (<100 nL) fluid sampling and sensing application.

Graphical abstract: Open nanofluidic films with rapid transport and no analyte exchange for ultra-low sample volumes

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Publication details

The article was received on 15 Feb 2018, accepted on 04 Jul 2018 and first published on 13 Jul 2018


Article type: Paper
DOI: 10.1039/C8LC00186C
Citation: Lab Chip, 2018, Advance Article
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    Open nanofluidic films with rapid transport and no analyte exchange for ultra-low sample volumes

    N. B. Twine, R. M. Norton, M. C. Brothers, A. Hauke, E. F. Gomez and J. Heikenfeld, Lab Chip, 2018, Advance Article , DOI: 10.1039/C8LC00186C

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