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Issue 9, 2020

Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery

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Abstract

Patient-centered therapeutic management for chronic medical conditions is a desired but unmet need, largely attributable to the lack of adequate technologies for tailored drug administration. While triggered devices that control the delivery of therapeutics exist, they often rely on impractical continuous external activation. As such, next generation continuously tunable drug delivery systems independent of sustained external activation remain an elusive goal. Here we present the development and demonstration of a silicon carbide (SiC)-coated nanofluidic membrane that achieves reproducible and tunable control of drug release via electrostatic gating. By applying a low-intensity voltage to a buried electrode, we showed repeatable and reproducible in vitro release modulation of three model analytes. A small fluorophore (Alexa Fluor 647), a large polymer poly(sodium 4-styrenesulfonate) and a medically relevant agent (DNA), were selected as representatives of small molecule therapeutics, polymeric drug carriers, and biological therapeutics, respectively. Unlike other drug delivery systems, our technology performed consistently over numerous cycles of voltage modulation, for over 11 days. Importantly, low power consumption and minimal leakage currents were achieved during the study. Further, the SiC coating maintained integrity and chemical inertness, shielding the membrane from degradation under simulated physiological and accelerated conditions for over 4 months. Through leveraging the flexibility offered by electrostatic gating control, our technology provides a valuable strategy for tunable delivery, setting the foundation for the next generation of drug delivery systems.

Graphical abstract: Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery

Supplementary files

Article information


Submitted
05 Feb 2020
Accepted
27 Mar 2020
First published
02 Apr 2020

This article is Open Access

Lab Chip, 2020,20, 1562-1576
Article type
Paper

Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery

N. Di Trani, A. Silvestri, A. Sizovs, Y. Wang, D. R. Erm, D. Demarchi, X. Liu and A. Grattoni, Lab Chip, 2020, 20, 1562 DOI: 10.1039/D0LC00121J

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