Microneedle-based sensors for medical diagnosis
The field of microneedle sensors is reviewed discussing current trends and future applications.
Processing and surface modification of polymer nanofibers for biological scaffolds: a review
This review discusses existing and emerging polymeric nanofiber fabrication techniques, fiber surface modification via post-processing, and their combined effects on cell adhesion, proliferation, and migration.
Heterotypic supramolecular hydrogels
We reviewed heterotypic supramolecular hydrogels containing more than one component to illustrate their promise as soft biomaterials.
Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering
Pluripotent stem cell derived liver cells (hepatocytes) represent a promising alternative to primary tissue for biological and clinical applications.
Oxygen delivering biomaterials for tissue engineering
Various technologies have been developed to increase oxygen delivery in vivo and enhance the effectiveness of tissue engineering strategies. The article provides an overview of the underlying mechanisms driving these technologies.
Bioinspired materials for regenerative medicine: going beyond the human archetypes
Living organisms are skilful innovators and fabricators of materials, driven by the forces of evolution. We describe the translation process between natural material innovations and human tissue engineering.
Nanostructure-based surface-enhanced Raman scattering biosensors for nucleic acids and proteins
Nanostructure-based SERS platforms have been developed for nucleic acid and protein detection ranging from label-free, labeled and multiplex analyses.
Programmed planar-to-helical shape transformations of composite hydrogels with bioinspired layered fibrous structures
Composite hydrogels with both in-plane and out-of-plane structural gradient are fabricated by multi-step photolithography and exhibit programmed deformations and shape transformations under stimulation.
Viscosity-controlled printing of supramolecular-polymeric hydrogels via dual-enzyme catalysis
Hybrid hydrogels based on a guanidinium-containing oligopeptide are prepared via dual-enzyme-triggered reactions. An extended time window is available for in situ viscosity-controlled 3D printing.
Facile green synthesis of calcium carbonate/folate porous hollow spheres for the targeted pH-responsive release of anticancer drugs
Calcium carbonate/folate porous hollow spheres were prepared in a facile manner and used for the targeted delivery and pH-responsive sustained release of anticancer drugs.
A novel method for the synthesis of 1,2-benzisoxazoline-3-one and its application to hypochlorite recognition
The reaction of salicylhydroxamic acid with hypochlorite produces 1,2-benzisoxazoline-3-one, a heterocycle that contains a fluorophore.
Ultrasensitive ELISA+ enhanced by dendritic mesoporous silica nanoparticles
Ultrasensitive ELISA+ assay has been developed with a 2000 times enhancement of detection sensitivity compared to the commercial ELISA kit in serum.
High performance Cu/Cu2O nanohybrid electrocatalyst for nonenzymatic glucose detection
Described herein are Cu/Cu2O nanohybrids prepared via potential oscillation, and their high performance for nonenzymatic glucose detection applications.
Target-triggered autonomous assembly of DNA polymer chains and its application in colorimetric nucleic acid detection
One-dimensional DNA polymer chains were obtained based on the catalyzed hairpin assembly and sticky end self-assembly, which led to a signal amplified colorimetric nucleic acid assay.
Fluorinated smart micelles as enzyme-responsive probes for 19F-magnetic resonance
Labeling smart PEG–dendron hybrids with fluorine-containing groups transform their micelles into enzyme-responsive probes for 19F-magnetic resonance.
Cobalt disulfide nanowires as an effective fluorescent sensing platform for DNA detection
Cobalt disulfide nanowires are synthesized in solution using a facile two-step hydrothermal method for the first time and applied as an effective sensing platform for nucleic acid detection.
The first visually observable three-mode antibiotic switch and its relative 3D printing assisted applications
To regulate antibiotic treatments, the first visible three-mode antibiotic switch with residual removable characteristics was realized in this report.
N-dots as a photoluminescent probe for the rapid and selective detection of Hg2+ and Ag+ in aqueous solution
New N-dots for the sensitive and selective detection of Hg2+ and Ag+ without surface modifications.
Versatile rare-earth oxide nanocomposites: enhanced chemo/photothermal/photodynamic anticancer therapy and multimodal imaging
A novel theranostic nanocomposite was assembled by a stepwise modification of rare-earth oxide nanoparticles; both the photothermal and photodynamic therapy effects are enhanced due to the effective light protection of a two-photon sensitized Eu3+ complex.
A novel triphenylamine-BODIPY dendron: click synthesis, near-infrared emission and a multi-channel chemodosimeter for Hg2+ and Fe3+
A novel near-infrared emission triphenylamine-BODIPY dendron for Hg2+ and Fe3+ detection, fluorescent nanoparticle and living cell imaging.
Phase-changeable and bubble-releasing implants for highly efficient HIFU-responsive tumor surgery and chemotherapy
A multifunctional poly(lactic-co-glycolic acid) (PLGA)-based solid implant was constructed within a tumor for highly efficient HIFU-responsive tumor surgery and chemotherapy.
Regulation of local bone remodeling mediated by hybrid multilayer coating embedded with hyaluronan-alendronate/BMP-2 nanoparticles on Ti6Al7Nb implants
Hyaluronate-alendronate/BMP-2 nanoparticles were inserted into Gel/Chi multilayers on Ti6Al7Nb for enhancing BMP-2 stability and promoting local osteogenesis under osteoporosis.
Regulation of the growth, morphology, mechanical properties and biocompatibility of natural polysaccharide-based multilayers by Hofmeister anions
Herein the optimization of the physicochemical properties and surface biocompatibility of polyelectrolyte multilayers of the natural, biocompatible and biodegradable, linear polysaccharides hyaluronan and chitosan by Hofmeister anions was systematically investigated.
Covalent crosslinking of graphene oxide and carbon nanotube into hydrogels enhances nerve cell responses
Chemically crosslinking GOa and CNTpega followed by in situ reduction fabricated a conductive rGOa–CNTpega–OPF hydrogel that strongly stimulated neurite growth.
Overcoming ABCG2-mediated multidrug resistance by a mineralized hyaluronan–drug nanocomplex
A multicomponent nanocomplex generated by hyaluronan-based biomineralization was successfully employed to combat ABCG2-mediated multidrug resistance.
Synthesis of EDTA-assisted CeVO4 nanorods as robust peroxidase mimics towards colorimetric detection of H2O2
CeVO4 nanorods were developed as novel, simple and highly sensitive biomimetic catalysts and used for colorimetric detection of H2O2.
Competitive ligand exchange of crosslinking ions for ionotropic hydrogel formation
We describe a new approach to form hydrogels of ionotropic polymers using competitive displacement of chelated ions. This strategy enables control of ion release kinetics within an aqueous polymer solution and thus control over gelation kinetics across a wide range of pH.
Graphene oxide nanohybrid that photoreleases nitric oxide
Covalent functionalization of graphene oxide with a suitable NO photodonor leads to a nanohybrid material that releases NO under visible light and has potential applications in biomedical research.
A comparative study of the mechanical properties of hybrid double-network hydrogels in swollen and as-prepared states
Significant efforts have been made to develop very tough hydrogels at both swelling and as-prepared states towards many scientific and industrial applications.
A gold nanostar based multi-functional tumor-targeting nanoplatform for tumor theranostic applications
A gold nanostar based multi-functional tumor-targeting nanoplatform (DOX/GNSTs–PEG/PEI–FA) for tumor theranostic applications.
Electron transfer driven highly valent silver for chronic wound treatment
This paper shows that reducing the dose of silver, additionally conferring electron transfer potential, could simultaneously achieve good biocompatibility and strong bactericidal ability without introducing extra chemical residuals for chronic wound treatment.
Preparation of gelatin/Fe3O4 composite scaffolds for enhanced and repeatable cancer cell ablation
Gelatin/Fe3O4 composite scaffolds with controlled pore structures were prepared by a facile ice particulate templating method and they showed great potential for near-infrared photothermal cancer therapy.
Engineering DN hydrogels from regenerated silk fibroin and poly(N-vinylcaprolactam)
The development of biocompatible hydrogels that possess adequate elasticity and toughness to withstand mechanically active environments, remains a significant challenge for tissue engineering applications. In this study, a family of silk-based double network hydrogels have been fabricated that display elasticity closer to native cartilage.
A robust double-network hydrogel with under sea water superoleophobicity fabricated via one-pot, one-step reaction
A robust double-network (DN) hydrogel fabricated by a one-pot, one-step reaction is reported.
Dual responsive mesoporous silica nanoparticles for targeted co-delivery of hydrophobic and hydrophilic anticancer drugs to tumor cells
Dual responsive mesoporous silica nanoparticles integrating stepwise tumor targeting and co-delivery of multiple anticancer drugs were developed to attenuate the drug resistance of cancer cells.
Surface modification with E-cadherin fusion protein for mesenchymal stem cell culture
To effectively expand human mesenchymal stem cells (hMSCs) in vitro without affecting their innate biological properties, a fusion protein (hE-cad-Fc) was fabricated and used as a biomimetic matrix for MSC culture surface modification.
Nanostrontium ranelate incorporated injectable hydrogel enhanced matrix production supporting chondrogenesis in vitro
An injectable strontium ranelate nanoparticle-loaded composite gel provides a required environment for chondrogenesis, supplemented with the controlled release of strontium ranelate.
Facile fabrication of amphiphilic AIE active glucan via formation of dynamic bonds: self assembly, stimuli responsiveness and biological imaging
A one-pot strategy has been developed for the preparation of stimuli responsive AIE active glucan through formation of a dynamic Schiff base and a phenyl borate.
Azo-functionalized Fe3O4 nanoparticles: a near-infrared light triggered drug delivery system for combined therapy of cancer with low toxicity
A smart drug delivery system based on thermo-sensitive molecule was designed. When exposed to near infrared (NIR) light, Fe3O4 nanoparticles transfer the light to heat rapidly, leading to the cleavage of the Azo linker and the release of DOX.
Soy protein-directed one-pot synthesis of gold nanomaterials and their functional conductive devices
Gold nanomaterials were synthesized via a facile and green method, using soy protein isolate as reductant, template, and capping agent.
Laminar ventricular myocardium on a microelectrode array-based chip
Micromolded gelatin can be used to engineer laminar human myocardium on microelectrode array chips for electrophysiological studies and drug testing.
Development of a cell delivery system using alginate microbeads for tissue regeneration
Alginate microbeads incorporating adipose-derived stem cells (ASCs) have potential for delivering viable cells capable of facilitating tissue regeneration.
“Stealthy” chitosan/mesoporous silica nanoparticle based complex system for tumor-triggered intracellular drug release
A pH- and redox-sensitive “stealthy” chitosan/mesoporous silica nanoparticle-based complex system is prepared for tumor-triggered intracellular drug release.
Tunable self-assembly of Irinotecan-fatty acid prodrugs with increased cytotoxicity to cancer cells
A small library of Irinotecan-fatty acid prodrugs which can self-assemble into different nanostructures is constructed to achieve enhanced cytotoxicity.
The synergetic effect of nano-structures and silicon-substitution on the properties of hydroxyapatite scaffolds for bone regeneration
Control over the morphology and chemical composition of hydroxyapatite (HAp) bioceramic scaffolds is of great importance for their applications.
Anticoagulant sodium alginate sulfates and their mussel-inspired heparin-mimetic coatings
We synthesized novel sodium alginate sulfates (SASs) with different sulfation degrees. All the SASs, DA-g-SASs, and coated substrates had good anticoagulant properties and biocompatibilit.
Diblock- and triblock-copolymer based mixed micelles with high tumor penetration in vitro and in vivo
A series of self-assembled mixed micelles composed of TPGS and Pluronics were fabricated and their cellular uptake and exocytosis behaviors were studied in 2D cell and 3D tumor spheroid models.
Microgels with tunable affinity-controlled protein release via desolvation of self-assembled peptide nanofibers
We demonstrate an approach to fabricate microgels from self-assembled peptide nanofibers via desolvation. Proteins can be co-desolvated with nanofibers to create protein-loaded microgels. Modifying nanofibers with a protein-binding ligand provides tunable affinity-controlled protein release.
Microfluidically fabricated pH-responsive anionic amphiphilic microgels for drug release
Novel amphiphilic microgels with hydrophobic and hydrophilic monomer units on the polymer chains were fabricated with an on-chip polymerisation methodology using a novel chip design.
Targeting mitochondrial DNA with a two-photon active Ru(II) phenanthroline derivative
A novel phenanthroline Ru(II) derivative for targeting mitochondrial DNA was designed and its potential applications in biological processes were highlighted.
3D-printed bioceramic scaffolds with a Fe3O4/graphene oxide nanocomposite interface for hyperthermia therapy of bone tumor cells
Magnetic scaffolds display prominent magnetothermal ability, and can effectively kill tumor cells in an alternating magnetic field and improve bone formation ability in vitro.
A multifunctional core–shell nanoplatform for enhanced cancer cell apoptosis and targeted chemotherapy
A novel multifunctional nanoplatform was designed based on the combination of silver nanoparticles (AgNPs) with nucleolin-targeted and doxorubicin (Dox)-loaded manganese dioxide (MnO2) nanosheets to induce enhanced cancer cell apoptosis and targeted chemotherapy.
Tracking translocation of glucan microparticles targeting M cells: implications for oral drug delivery
Model glucan microparticles (GMs) targeting M cells are employed to track translocation through M cell pathways as well as to various organs via the systemic circulation.
Disulfide-crosslinked albumin hydrogels
Albumin hydrogels crosslinked by disulfide bonds between the protein's own thiol groups.
Mussel-inspired coatings on Ag nanoparticle-conjugated carbon nanotubes: bactericidal activity and mammal cell toxicity
Silver nanoparticle (AgNP)-based nanohybrids have been proposed as efficient antimicrobial agents because of their robust bactericidal activity.
Surface functionalized halloysite nanotubes decorated with silver nanoparticles for enzyme immobilization and biosensing
Illustrating the selective modification of the HNTs for the incorporation of AgNPs and site-specific covalent immobilization of the GOx enzymes.
A novel multifunctional biomimetic Au@BSA nanocarrier as a potential siRNA theranostic nanoplatform
A novel siRNA nanocarrier based on biomimetic Au@BSA nanoflowers is fabricated which could serve as a potential theranostic nanoplatform.
Synthesis of a three-layered SiO2@Au nanoparticle@polyaniline nanocomposite and its application in simultaneous electrochemical detection of uric acid and ascorbic acid
A novel three-layered SiO2@AuNP@PANI nanocomposite was synthesized and adopted for the simultaneous electrochemical determination of uric acid and ascorbic acid.
The stimulation of osteogenic differentiation of embryoid bodies from human induced pluripotent stem cells by akermanite bioceramics
We report the stimulation of osteogenic differentiation of embryoid body (EB) cells derived from human induced pluripotent stem cells (iPSCs) by akermanite bioceramics.
Phosphorylated poly(sebacoyl diglyceride) – a phosphate functionalized biodegradable polymer for bone tissue engineering
This study demonstrates a simply powerful way to make therapeutic materials: using small functional units (phosphates) to control bioactivity (osteogenesis).
Epitope imprinting enhanced IMAC (EI-IMAC) for highly selective purification of His-tagged protein
Selectivity of epitope imprinted sites is introduced on the IMAC surface through epitope surface imprinting. The obtained epitope imprinting enhanced IMAC (EI-IMAC) could purify His-tagged proteins with high selectivity without any major interference from the host proteins.
MMP-responsive theranostic nanoplatform based on mesoporous silica nanoparticles for tumor imaging and targeted drug delivery
A novel mesoporous silica-based multifunctional theranostic nanoplatform was reported, which can not only achieve MMP-2-activated fluorescence imaging, but also realize tumor targeted drug delivery and drug release indicating.
Characterisation of nanoscale carbide precipitation in as-cast Co–Cr–W-based dental alloys
The results of the present study indicate the importance of local chemistry along with carbide precipitation in the optimization of alloy design for achieving desirable properties such as high strength, ductility, and corrosion resistance in dental Co–Cr-based cast alloys.
Functionalizing micro-3D-printed protein hydrogels for cell adhesion and patterning
A versatile and dynamic photoconjugation platform is introduced that provides high, 3D spatial resolution for functionalizing micro-3D-printed (μ-3DP) hydrogels. Schwann cells are patterned on μ-3DP hydrogels precisely labeled with RGD, a cell adhesive peptide, demonstrating utility of this platform for cell culture applications.
Three label-free thrombin aptasensors based on aptamers and [Ru(bpy)2(o-mopip)]2+
The label free aptasensor based on an aptamer pair and [Ru(bpy)2(o-mopip)]2+–GO has been successfully applied to sandwich assays for thrombin detection.
Osmo-solidification of all-aqueous emulsion with enhanced preservation of protein activity
An “osmo-solidification” approach that solidifies all-aqueous emulsion droplets for encapsulating proteins with superior preservation of their activity.
A large-deformation phase transition electrothermal actuator based on carbon nanotube–elastomer composites
Large actuation occurs while the closed water is boiled to steam at an induced heating power. A closed liquid circulation system based on two of these actuators can work like a real heart.
Cellular endocytosis and trafficking of cholera toxin B-modified mesoporous silica nanoparticles
Mesoporous silica nanoparticles were functionalized with cholera toxin subunit B protein to influence their intracellular trafficking pathways.
A highly specific graphene platform for sensing collagen triple helix
We have designed a dye-labeled, highly positively charged single stranded collagen (ssCOL) peptide probe whose adsorption into GO quenches its fluorescence. The hybridization of the ssCOL probe with a complementary target sequence forms a triple stranded collagen (tsCOL) peptide, resulting in the retention of the fluorescence of the probe.
Biomimetic gelatin methacrylamide hydrogel scaffolds for bone tissue engineering
The biomimetic GelMA scaffolds which have highly porous, interconnected macropores, and rough surface could promote ADSC to differentiate into osteoblasts and bone formation.
About this collection
This on-going web collection features all the articles published in Journal of Materials Chemistry B in 2016 marked as HOT, as recommended by referees. Congratulations to all the authors whose articles are featured!