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Issue 20, 2016
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Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering

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Abstract

Pluripotent stem cell derived liver cells (hepatocytes) represent a promising alternative to primary tissue for biological and clinical applications. To date, most hepatocyte maintenance and differentiation systems have relied upon the use of animal derived components. This serves as a significant barrier to large scale production and application of stem cell derived hepatocytes. Recently, the use of defined biologics has overcome those limitations in two-dimensional monolayer culture. In order to improve the cell phenotype further, three-dimensional culture systems have been employed to better mimic the in vivo situation, drawing upon materials chemistry, engineering and biology. In this review we discuss efforts in the field, to differentiate pluripotent stem cells towards hepatocytes under defined conditions.

Graphical abstract: Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering

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Publication details

The article was received on 05 Feb 2016, accepted on 14 Apr 2016 and first published on 15 Apr 2016


Article type: Review Article
DOI: 10.1039/C6TB00331A
Citation: J. Mater. Chem. B, 2016,4, 3433-3442
  • Open access: Creative Commons BY license
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    Pluripotent stem cell derived hepatocytes: using materials to define cellular differentiation and tissue engineering

    B. Lucendo-Villarin, H. Rashidi, K. Cameron and D. C. Hay, J. Mater. Chem. B, 2016, 4, 3433
    DOI: 10.1039/C6TB00331A

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