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Issue 36, 2016
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Processing and surface modification of polymer nanofibers for biological scaffolds: a review

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Abstract

Polymeric fibrous constructs possess high surface area-to-volume ratios when compared with solid substrates and are quite commonly used as tissue engineering and cell growth scaffolds. An overview of important design and material considerations for fibrous scaffolds as well as an outline of both established and emerging solution- and melt-based fabrication techniques is provided. Innovative post-process surface modification avenues using “click” chemistry with both single and dual active cues as well as gradient cues, which maintain the fibrous structure are described. By combining process parameters with post-process surface modification, researchers have been able to selectively tune cellular response after seeding and culturing on fibrous constructs.

Graphical abstract: Processing and surface modification of polymer nanofibers for biological scaffolds: a review

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Publication details

The article was received on 24 May 2016, accepted on 21 Jul 2016 and first published on 10 Aug 2016


Article type: Review Article
DOI: 10.1039/C6TB01303A
J. Mater. Chem. B, 2016,4, 5958-5974

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    Processing and surface modification of polymer nanofibers for biological scaffolds: a review

    A. M. Jordan, V. Viswanath, S. Kim, J. K. Pokorski and L. T. J. Korley, J. Mater. Chem. B, 2016, 4, 5958
    DOI: 10.1039/C6TB01303A

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