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Issue 35, 2016
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Graphene oxide nanohybrid that photoreleases nitric oxide

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We report herein a photoresponsive nanoplatform that delivers nitric oxide (NO) on demand, achieved by the covalent functionalization of graphene oxide (GO) with an amino-terminated nitric oxide (NO) photodonor (NOP1). The resulting GO–NOP1 hybrid nanomaterial is dispersible in water, is very stable in the dark and has been thoroughly characterized by SEM, TEM, AFM, XRD, FTIR and UV-Vis absorption spectroscopy. Photolysis experiments demonstrate that the photodecomposition of the NO photoreleaser integrated into the GO scaffold occurs with an efficiency similar to that observed for a free model compound, ruling out any significant quenching effect (i.e. photoinduced energy/electron transfer) and accounting for the excellent preservation of its photochemical properties upon grafting. A combination of direct amperometric detection and indirect measurements based on a fluorometric assay prove that the remote-controlled release of NO from the GO–NOP1 nanoplatform is exclusively regulated by visible light stimuli.

Graphical abstract: Graphene oxide nanohybrid that photoreleases nitric oxide

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The article was received on 28 Jun 2016, accepted on 04 Aug 2016 and first published on 04 Aug 2016

Article type: Paper
DOI: 10.1039/C6TB01599A
Citation: J. Mater. Chem. B, 2016,4, 5825-5830
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    Graphene oxide nanohybrid that photoreleases nitric oxide

    N. Marino, S. Petralia, M. Perez-Lloret, J. Mosinger, S. Conoci and S. Sortino, J. Mater. Chem. B, 2016, 4, 5825
    DOI: 10.1039/C6TB01599A

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