Introduction to Biosensors
Shaoqin Liu and Ning Gu, Journal of Materials Chemistry B themed issue on Biosensors.
Assessing the range of enzymatic and oxidative tunability for biosensor design
This review aims to inspire novel biosensor design by addressing materials chemistries through the lense of enzymatic and oxidative susceptibility in the spectra of inflammatory disease biomarkers.
Enhanced biosensing strategies using electrogenerated chemiluminescence: recent progress and future prospects
An overview of enhancement strategies for highly sensitive ECL-based sensing of bioanalytes enabling early detection of cancer.
Nanomaterial-based biosensors for DNA methyltransferase assay
We review the recent advances in the development of nanomaterial-based biosensors for DNA methyltransferase assay.
Stretchable and tough conductive hydrogels for flexible pressure and strain sensors
This review summarises recent advances in stretchable and tough conductive hydrogel sensors for wearable and implantable devices.
Nanomaterial-based gas sensors used for breath diagnosis
Gas-sensing applications commonly use nanomaterials (NMs) because of their unique physicochemical properties, including a high surface-to-volume ratio, enormous number of active sites, controllable morphology, and potential for miniaturisation.
Aptamer-based nanostructured interfaces for the detection and release of circulating tumor cells
This paper summarizes various aptamer-functionalized nanostructured interfaces for the detection and release of circulating tumor cells.
Wearable biochemical sensors for human health monitoring: sensing materials and manufacturing technologies
Recent achievements and challenges in materials and manufacturing technologies of sensing electrodes in wearable biosensors have been highlighted.
Genetically encoded light-up RNA aptamers and their applications for imaging and biosensing
Light-up RNA aptamers and their applications in bioimaging and biosensing of small ligands and biomacromolecules are described.
From design to applications of stimuli-responsive hydrogel strain sensors
Stimuli-responsive hydrogel strain sensors that synergize the advantages of both hydrogel and smart functional materials have attracted increasing interest from material design to emerging applications in health monitors and human–machine interfaces.
Recent development of biofuel cell based self-powered biosensors
BFC-based SPBs have been used as power sources for other devices and as sensors for detecting toxicity and BOM.
Advances in functional nucleic acid based paper sensors
This article provides an extensive review of paper-based sensors that utilize functional nucleic acids, particularly DNA aptamers and DNAzymes, as recognition elements.
Recent advances of tissue-interfaced chemical biosensors
This review discusses recent advances of tissue interfaced chemical biosensors, highlights current challenges and gives an outlook on future possibilities.
Aggregation-induced emission luminogens for RONS sensing
The development of AIE bioprobes for RONS sensing in living systems is now summarized. We discuss some representative examples of AIEgen based bioprobes in terms of their molecular design, sensing mechanism and sensitive sensing in vitro and in vivo.
An efficient strategy for circulating tumor cell detection: surface-enhanced Raman spectroscopy
Circulating tumor cells (CTCs) are circulating cancer cells that shed from tumor tissue into blood vessels and circulate in the blood to invade other organs, which results in fatal metastases. Surface-enhanced Raman scattering (SERS) has great potentials in CTCs detection.
Controlled/“living” radical polymerization-based signal amplification strategies for biosensing
Controlled/“living” radical polymerization-based signal amplification strategies and their applications in highly sensitive biosensing of clinically relevant biomolecules are reviewed.
Emerging intraoral biosensors
Intraoral biosensors are emerging as reliable medical devices for non-invasive health-care monitoring.
Multi-emission metal–organic framework composites for multicomponent ratiometric fluorescence sensing: recent developments and future challenges
Ratiometric fluorescence sensors that are achieved via the ratiometric fluorescence intensity changes of emission peaks based on multi-emission fluorescence probes show a huge advantage.
Biosensors and bioassays for determination of matrix metalloproteinases: state of the art and recent advances
This review highlights the recent advances in nanomaterial-based immunoassays for MMP abundance measurements and nanomaterial-based biosensors for MMP activity determination.
Luminescence approaches for the rapid detection of disease-related receptor proteins using transition metal-based probes
Abnormally expressed receptor proteins are proved to be one of the crucial biomarkers for specific human diseases. Transitional metal based strategies possess delightful strengths in the in-field and real-time visualization of receptor proteins.
Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy
A tunable linker-based signal amplification strategy yielding 6-fold enhanced sensitivity for low magnification dark-field quantitative assays.
Ti3C2Tx MXene-derived TiO2/C-QDs as oxidase mimics for the efficient diagnosis of glutathione in human serum
A Ti3C2Tx MXene-derived TiO2/C-QD oxidase mimic was developed and used for the efficient diagnosis of glutathione in human serum.
A dual-targeted CeO2–DNA nanosensor for real-time imaging of H2O2 to assess atherosclerotic plaque vulnerability
A novel dual-targeted CeO2–DNA nanosensor by modifying with folic acid (FA) and CD36 antibody was designed.
Platinum ions mediate the interactions between DNA and carbon quantum dots: diagnosis of MRSA infections
The isothermal amplification products of mecA and femA genes induce the fluorescence quenching of platinum ions-capped carbon quantum dots to allow the specific identification of methicillin-resistant Staphylococcus aureus.
Optical nanogap antennas as plasmonic biosensors for the detection of miRNA biomarkers
Gold nanogap antennas fabricated by hole-mask colloidal lithography as sensitive substrates for plasmonic biosensing.
Toehold-regulated competitive assembly to accelerate the kinetics of graphene oxide-based biosensors
With toehold-regulation, the kinetics of graphene oxide-based biosensors can be accelerated.
A perylenetetracarboxylic dianhydride and aniline-assembled supramolecular nanomaterial with multi-color electrochemiluminescence for a highly sensitive label-free immunoassay
A novel multi-color ECL nanomaterial assembled from 3,4,9,10-perylenetetracarboxylic dianhydride (PTCDA) and aniline (An) was used for highly sensitive label-free CEA detection.
Novel perylene probe-encapsulated metal–organic framework nanocomposites for ratiometric fluorescence detection of ATP
Schematic illustration of PDI@ZIF-8 nanocomposite synthesis and ratiometric fluorescence assay for ATP sensing. 2-MIm: 2-methylimidazole.
Silver nanoprism-based plasmonic ELISA for sensitive detection of fluoroquinolones
Silver nanoprism-based plasmonic ELISA for qualitative and quantitative detection of fluoroquinolones.
Structurally coloured contact lens sensor for point-of-care ophthalmic health monitoring
A structurally coloured contact lens sensor has been developed for point-of-care diagnosis of eye diseases.
Flexible and stretchable dual mode nanogenerator for rehabilitation monitoring and information interaction
Sensors with flexibility and stretchability are the key functional modules of converter between mechanical motions and electric signals for intelligent robots and rehabilitation training systems.
Boosting biomolecular interactions through DNA origami nano-tailored biosensing interfaces
Nano-tailored DNA origami designs nanostructure the bioreceptor layer of encoded microparticles in an innovative microfluidic platform, hereby boosting biomolecular interactions.
Nucleoside-based fluorescent carbon dots for discrimination of metal ions
Using nucleosides and citrate as starting materials, a series of fluorescent carbon dots were synthesized showing different quenching properties by metal ions for their detection by a sensor array.
Glutamate detection at the cellular level by means of polymer/enzyme multilayer modified carbon nanoelectrodes
Carbon nanoelectrodes in the sub-micron range were modified with an enzyme cascade immobilized in a spatially separated polymer double layer system for the detection of glutamate at the cellular level.
Stretchable gold fiber-based wearable electrochemical sensor toward pH monitoring
A stretchable gold fiber-based wearable electrochemical pH two-electrodes sensing system for human health monitoring.
Biomolecular detection, tracking, and manipulation using a magnetic nanoparticle-quantum dot platform
Fluorescent and magnetic materials play a significant role in biosensor technology, enabling sensitive quantification and separations with applications in diagnostics, purification, quality control, and therapeutics.
Graphene–nucleic acid biointerface-engineered biosensors with tunable dynamic range
Programmed biosensors with tunable quantification range and higher specificity have been constructed by engineering graphene–nucleic acid biointerfaces.
Electrodeposition of nickel nanostructures using silica nanochannels as confinement for low-fouling enzyme-free glucose detection
This work reports an enzyme-free glucose sensor based on nickel nanostructures electrodeposited on a fluorine-doped tin oxide (FTO) electrode modified with a silica nanochannel membrane (SNM).
Highly efficient electrochemiluminescence of ruthenium complex-functionalized CdS quantum dots and their analytical application
Highly efficient electrochemiluminescence of ruthenium complex-functionalized CdS quantum dots via ECL resonance energy transfer (ECL-RET) and their analytical application.
A paper-based SERS assay for sensitive duplex cytokine detection towards the atherosclerosis-associated disease diagnosis
Novel SERS based sensing assay was built by combining nanoporous membrane with sandwich immunoassay for duplex cytokines detection. It can be used as a promising candidate for clinical application due to its excellent performance in human serum.
Ultrasensitive self-enhanced electrochemiluminescence sensor based on novel PAN@Ru@PEI@Nafion nanofiber mat
A novel self-enhanced electrochemiluminescence nanofiber mat was for the first time prepared by one-step electrospinning a mixture of polyacrylonitrile, Ru(bpy)32+, poly(ethylenimine) and Nafion.
A single-liquid miniature biofuel cell with boosting power density via gas diffusion bioelectrodes
A single-liquid glucose–O2 cell is constructed by gas diffusion electrode. O2 diffusion directly from air to active sites of enzyme enhances the enzymatic reaction rate. The maximum power output density of the cell is 53 μW cm−2.
Turn-on fluorescent glutathione detection based on lucigenin and MnO2 nanosheets
A GSH sensing platform using lucigenin as a fluorescent probe in the presence of MnO2 nanosheets was reported for the first time.
Functionalized tungsten disulfide nanotubes for dopamine and catechol detection in a tyrosinase-based amperometric biosensor design
Functionalized tungsten disulfide nanotubes were evaluated as an enzyme support for electrochemical biosensors.
A self-assembled RNA-triple helix hydrogel drug delivery system targeting triple-negative breast cancer
A novel RNA-triple-helix hydrogel for treatment of triple negative breast cancers (TNBCs) by incorporating RNA-triple-helix and siRNA duplexes of CXCR4 into the same RNA nanoparticles was developed, without the synthetic polycationic reagents.
A colorimetric and electrochemical dual-mode biosensor for thrombin using a magnetic separation technique
A colorimetric and electrochemical dual-mode biosensor for thrombin based on the combination of a magnetic separation technique and a signal amplification strategy.
Biotinylated and fluorophore-incorporated polymeric mixed micelles for tumor cell-specific turn-on fluorescence imaging of Al3+
We construct tumor-targeting fluorescent mixed nano-micelles for tumor cell-specific turn-on fluorescence imaging of Al3+.
About this collection
Guest edited by Shaoqin Liu (Harbin Institute of Technology) and Ning Gu (Southeast University).
In the last couple of decades, a broad range of materials, including organic small molecules, inorganic materials, hydrogels, hybrids, or emerging nanomaterials and structures, have been proposed for the biosensors, skin-like electronics, implantable electronics, medicine diagnosis and monitoring, and so on. These new materials results in numerous new methods and techniques. These technologies have shown great advantages over conventional assays, particularly in sensitivity, selectivity, and practicality.
This themed issue in Journal of Materials Chemistry B aims to explore the latest developments in the materials design and synthesis, novel design and function of biosensors and bioelectronics, and potential applications for healthcare and biomedicine diagnosis.