Enhanced Biosensing Strategies from Electrogenerated Chemiluminescence: Recent Progress and Future Perspective
The need for ultrasensitive and highly accurate bioassays is critically required for the early detection of various biomarkers and diagnosis of cancer. Electrogenerated Chemiluminescence (ECL) is one such technique which shows powerful analytical ability by incorporating ECL active species for sensitive detection of targets. In this regard, the development of ECL as an assay technique is constantly being pushed for better performance and lower detection limits. Incorporation of sensitive immunosensing and aptasensing methods with ECL has the ability to multiply the advantages several-fold. The recent progress and methods utilized for the enhancement and amplification of ECL detection techniques based on highly sensitive immunosensors and aptasensors has been discussed in this review with regard to widely popular techniques.