Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy

Author affiliations

Abstract

Nanoparticle-enhanced assays read by high-magnification dark-field microscopy require time-intensive analysis methods subject to selection bias, which can be resolved by using low magnification dark-field assays (LMDFA), at the cost of reduced sensitivity. We have simulated and experimentally validated a tunable linker-based signal amplification strategy yielding 6-fold enhanced LMDFA sensitivity.

Graphical abstract: Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy

  • This article is part of the themed collection: Biosensors
Back to tab navigation

Supplementary files

Article information


Submitted
08 Feb 2020
Accepted
19 May 2020
First published
19 May 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Communication

Simulation-directed amplifiable nanoparticle enhanced quantitative scattering assay under low magnification dark field microscopy

D. Sun, L. Yang, C. J. Lyon and T. Hu, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB00350F

Social activity

Search articles by author

Spotlight

Advertisements