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Novel perylene probe-encapsulated metal–organic framework nanocomposites for ratiometric fluorescence detection of ATP

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Abstract

Adenosine triphosphate (ATP) plays an important role in various biological processes and the ATP level is closely associated with many diseases. Herein, a novel ratiometric fluorescence assay for ATP was developed based on the excimer-monomer transfer of a perylene probe. By encapsulating a perylene probe, N,N′-bis(6-caproic acid)-3,4:9,10-perylenediimide (PDI), into zeolitic imidazolate framework-8 (ZIF-8) nanocrystals, fluorescent nanocomposites (PDI@ZIF-8) with significant excimer emission of the perylene probe were prepared for the first time. The presence of ATP will trigger the decomposition of PDI@ZIF-8 due to much stronger coordination between ATP and Zn2+ than that of 2-methylimidazole and Zn2+. As a result, the encapsulated PDI probes were released, leading to significantly increased monomer emission accompanying the decrease in the excimer emission. The excimer-monomer transition signal was utilized for ratiometric ATP sensing and its potential application for detecting ATP in cell lysates was also successfully demonstrated.

Graphical abstract: Novel perylene probe-encapsulated metal–organic framework nanocomposites for ratiometric fluorescence detection of ATP

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Supplementary files

Article information


Submitted
21 Oct 2019
Accepted
23 Jan 2020
First published
24 Jan 2020

J. Mater. Chem. B, 2020, Advance Article
Article type
Paper

Novel perylene probe-encapsulated metal–organic framework nanocomposites for ratiometric fluorescence detection of ATP

X. Zhou, J. Li, L. Tan, Q. Li and L. Shang, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/C9TB02319D

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