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Themed collection Journal of Materials Chemistry B Emerging Investigators

44 items
Profile

Journal of Materials Chemistry B profiles: contributors to the Emerging Investigators 2020 issue

Journal of Materials Chemistry B profiles contributors to the Emerging Investigators 2020 issue.

Graphical abstract: Journal of Materials Chemistry B profiles: contributors to the Emerging Investigators 2020 issue
Highlight

Functional peptide-based drug delivery systems

Representative strategies for designing smart drug delivery systems by using functional peptides in the past few years are highlighted in this review.

Graphical abstract: Functional peptide-based drug delivery systems
Perspective

Aqueous surface gels as low friction interfaces to mitigate implant-associated inflammation

Soft implant surfaces should be designed with an eye toward natural, healthy biointerfaces, which use high water content aqueous gel gradients to reduce contact pressures and frictional shear stresses and thus reduce inflammation and discomfort.

Graphical abstract: Aqueous surface gels as low friction interfaces to mitigate implant-associated inflammation
Perspective

Chemoreactive nanomedicine

Triggering specific chemical reactions in the disease microenvironment can produce species for disease treatment that have high theranostic performance and low side effects on healthy cells/tissues.

Graphical abstract: Chemoreactive nanomedicine
From the themed collection: Journal of Materials Chemistry B HOT Papers
Perspective

Overcoming the biological barriers in the tumor microenvironment for improving drug delivery and efficacy

The strategies and obstacles for overcoming the barriers in the tumor microenvironment are presented.

Graphical abstract: Overcoming the biological barriers in the tumor microenvironment for improving drug delivery and efficacy
Review Article

Liquid-phase electron microscopy imaging of cellular and biomolecular systems

Liquid-phase electron microscopy, a new method for real-time nanoscopic imaging in liquid, makes it possible to study cells or biomolecules with a singular combination of spatial and temporal resolution. We review the state of the art in biological research in this growing and promising field.

Graphical abstract: Liquid-phase electron microscopy imaging of cellular and biomolecular systems
Review Article

Self-assembly of trigonal building blocks into nanostructures: molecular design and biomedical applications

This review introduces trigonal building blocks and summarizes their structural characteristics, self-assembly ability and biomedical applications.

Graphical abstract: Self-assembly of trigonal building blocks into nanostructures: molecular design and biomedical applications
Review Article

Self-immolative polymers in biomedicine

Biomedical use cases for self-immolative polymers.

Graphical abstract: Self-immolative polymers in biomedicine
Review Article

From cells-on-a-chip to organs-on-a-chip: scaffolding materials for 3D cell culture in microfluidics

Integrating ECM materials in microfluidics for 3D cell culture.

Graphical abstract: From cells-on-a-chip to organs-on-a-chip: scaffolding materials for 3D cell culture in microfluidics
From the themed collection: Editor’s Choice: Microfluidics
Review Article

Multimaterial and multifunctional neural interfaces: from surface-type and implantable electrodes to fiber-based devices

Development of neural interfaces from surface electrodes to fibers with various type, functionality, and materials.

Graphical abstract: Multimaterial and multifunctional neural interfaces: from surface-type and implantable electrodes to fiber-based devices
Review Article

Vapor-deposited functional polymer thin films in biological applications

Vapor-deposited polymer thin films empower the next-generation biological applications including bio-separations, biosensors & bio-MEMS, drug delivery and tissue engineering.

Graphical abstract: Vapor-deposited functional polymer thin films in biological applications
Review Article

Discovery and design of soft polymeric bio-inspired materials with multiscale simulations and artificial intelligence

Establishing the “Materials 4.0” paradigm requires intimate knowledge of the virtual space in materials design.

Graphical abstract: Discovery and design of soft polymeric bio-inspired materials with multiscale simulations and artificial intelligence
Open Access Review Article

Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

Selecting the appropriate nanoparticle, functionalization chemistry and sensing methodology can speed up the translation of liquid biopsies into the clinic.

Graphical abstract: Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies
From the themed collection: Recent Open Access Articles
Review Article

Engineering nanoparticles to tackle tumor barriers

Engineering strategies of nanoparticles were elaborated to overcome delivery barriers from the perspectives of trans-vascular transport and interstitial transport.

Graphical abstract: Engineering nanoparticles to tackle tumor barriers
Review Article

Recent progress in dynamic covalent chemistries for liquid crystal elastomers

This review article discusses the recent progress in designing, synthesizing and programming liquid crystal elastomers with different dynamic covalent bonds.

Graphical abstract: Recent progress in dynamic covalent chemistries for liquid crystal elastomers
Review Article

Biological applications of water-soluble polypeptides with ordered secondary structures

Herein, recent advances in the synthesis of the water-soluble polypeptides with ordered secondary structures via ring-opening polymerization of NCA/NTA and their biological applications are described.

Graphical abstract: Biological applications of water-soluble polypeptides with ordered secondary structures
From the themed collection: Journal of Materials Chemistry B HOT Papers
Review Article

Design of nanomaterials for applications in maternal/fetal medicine

This review discusses the design parameters that are important to consider when developing nanomaterials for applications in maternal/fetal health.

Graphical abstract: Design of nanomaterials for applications in maternal/fetal medicine
Communication

Enabling nanopore technology for sensing individual amino acids by a derivatization strategy

A derivatization strategy was demonstrated for reliable identification of individual amino acids using an α-hemolysin nanopore.

Graphical abstract: Enabling nanopore technology for sensing individual amino acids by a derivatization strategy
Communication

Programmable assembly of gold nanoparticle nanoclusters and lattices

Deterministic assembly of metallic nanoparticles (e.g. gold nanoparticles) into prescribed configurations has promising applications in many fields such as biosensing and drug delivery.

Graphical abstract: Programmable assembly of gold nanoparticle nanoclusters and lattices
Communication

Regulation of cell binding and entry by DNA origami mediated spatial distribution of aptamers

Customizing the spatial distribution of aptamers on DNA origami nanoboxes can regulate the internalization and proliferation of cancer cells.

Graphical abstract: Regulation of cell binding and entry by DNA origami mediated spatial distribution of aptamers
Communication

Effect of molecular weight and polymer composition on gallol-functionalized underwater adhesive

A gallol-functionalized polymer showed strong adhesion ability underwater. The effect of molecular weight and gallol content have been optimized resulting in the underwater adhesion strength as high as 4 MPa.

Graphical abstract: Effect of molecular weight and polymer composition on gallol-functionalized underwater adhesive
From the themed collection: Polymers in liquid formulations
Paper

Real-time monitoring of human Schwann cells on heparin-collagen coatings reveals enhanced adhesion and growth factor response

In this work, we evaluate the enhancing effect of six bilayers of heparin/collagen (HEP/COL)6 layer-by-layer coatings on human Schwann cell (hSCs) adhesion and proliferation in the presence or absence of nerve growth factor (NGF).

Graphical abstract: Real-time monitoring of human Schwann cells on heparin-collagen coatings reveals enhanced adhesion and growth factor response
Paper

Multimodal spectroscopic investigation of the conformation and local environment of biomolecules at an electrified interface

A combination of mid-infrared plasmons and time-resolved fluorescence are used to probe biomolecules at a buried electrochemically active interface.

Graphical abstract: Multimodal spectroscopic investigation of the conformation and local environment of biomolecules at an electrified interface
Paper

Antioxidant shape amphiphiles for accelerated wound healing

We reported a series of POSS-based antioxidant shape amphiphiles for preventing cell oxidative damage and promoting wound healing.

Graphical abstract: Antioxidant shape amphiphiles for accelerated wound healing
Open Access Paper

Anisotropic, porous hydrogels templated by lyotropic chromonic liquid crystals

Approaches to control the microstructure of hydrogels enable the control of cell–material interactions and the design of stimuli-responsive materials.

Graphical abstract: Anisotropic, porous hydrogels templated by lyotropic chromonic liquid crystals
From the themed collection: Recent Open Access Articles
Paper

Photo-degradable micelles for co-delivery of nitric oxide and doxorubicin

Photo-degradable triblock copolymers enable the co-delivery of nitric oxide and doxorubicin exerting an improved therapeutic effect.

Graphical abstract: Photo-degradable micelles for co-delivery of nitric oxide and doxorubicin
Paper

An antibody–supermolecule conjugate for tumor-specific targeting of tumoricidal methylated β-cyclodextrin-threaded polyrotaxanes

A conjugate of an anti-HER2 antibody and polyrotaxane containing methylated β-cyclodextrins (Me-PRX) was designed to achieve a tumor-specific delivery of Me-PRX. The antibody–Me-PRX conjugates efficiently uptaken into HER2-positive cells and induced autophagic cell death.

Graphical abstract: An antibody–supermolecule conjugate for tumor-specific targeting of tumoricidal methylated β-cyclodextrin-threaded polyrotaxanes
Paper

Ultra-thin, transparent, porous substrates as 3D culture scaffolds for engineering ASC spheroids for high-magnification imaging

We investigated a porous nanosheet to induce the formation of spheroids consisting of adipose-tissue derived stem cells, which is useful not only for engineering 3D cellular organization, but also for imaging the detailed structure of the spheroid.

Graphical abstract: Ultra-thin, transparent, porous substrates as 3D culture scaffolds for engineering ASC spheroids for high-magnification imaging
Paper

Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y1 receptor-overexpressed breast cancer

Y1 receptor ligand-modified nanobubbles could target breast cancer cells and improve therapeutic efficacy with reduced side effects under ultrasound irradiation during chemotherapy.

Graphical abstract: Active targeting nano-scale bubbles enhanced ultrasound cavitation chemotherapy in Y1 receptor-overexpressed breast cancer
Paper

Exploring the inner environment of protein hydrogels with fluorescence spectroscopy towards understanding their drug delivery capabilities

Time-resolved fluorescence have used to explore the inner surface and solvation dynamics within protein hydrogels assisting in rationalizing their drug binding and release capabilities.

Graphical abstract: Exploring the inner environment of protein hydrogels with fluorescence spectroscopy towards understanding their drug delivery capabilities
Open Access Paper

14N–1H HMQC solid-state NMR as a powerful tool to study amorphous formulations – an exemplary study of paclitaxel loaded polymer micelles

14N–1H HMQC experiments are powerful experiments to characterize amorphous drug–polymer formulations of paclitaxel yielding well-separated signals in the 14N dimension as well as information on the symmetry of 14N and 14N–1H interactions.

Graphical abstract: 14N–1H HMQC solid-state NMR as a powerful tool to study amorphous formulations – an exemplary study of paclitaxel loaded polymer micelles
From the themed collection: Recent Open Access Articles
Paper

An MRI contrast agent based on a zwitterionic metal-chelating polymer for hepatorenal angiography and tumor imaging

A zwitterionic MRI contrast agent Gd-PAA with exceptionally high r1 was designed for hepatorenal angiography and tumor imaging.

Graphical abstract: An MRI contrast agent based on a zwitterionic metal-chelating polymer for hepatorenal angiography and tumor imaging
Paper

Effect of conjugated (EK)10 peptide on structural and dynamic properties of ubiquitin protein: a molecular dynamics simulation study

Peptide conjugation modulates the stability and biological acitivty of proteins via the allosteric effect.

Graphical abstract: Effect of conjugated (EK)10 peptide on structural and dynamic properties of ubiquitin protein: a molecular dynamics simulation study
Paper

Gap-enhanced resonance Raman tags for live-cell imaging

Gap-enhanced resonance Raman tags enable long-term, high-resolution and high-speed (1 ms per pixel) live-cell imaging with a laser power of 50 μW.

Graphical abstract: Gap-enhanced resonance Raman tags for live-cell imaging
Paper

Tuning hydrogel properties with sequence-defined, non-natural peptoid crosslinkers

Helical peptoid crosslinkers confer tunable mechanical properties and enzymatic stability to hydrogels for cell culture.

Graphical abstract: Tuning hydrogel properties with sequence-defined, non-natural peptoid crosslinkers
Paper

Calcium alendronate-coated composite scaffolds promote osteogenesis of ADSCs via integrin and FAK/ERK signalling pathways

Calcium alendronate-coated composite scaffolds not only displayed excellent cytocompatibility and cell adhesion but also promoted osteogenic differentiation of ADSCs.

Graphical abstract: Calcium alendronate-coated composite scaffolds promote osteogenesis of ADSCs via integrin and FAK/ERK signalling pathways
Paper

Phosphate-responsive 2D-metal–organic-framework-nanozymes for colorimetric detection of alkaline phosphatase

Phosphate-responsive peroxidase-mimicking two-dimensional-metal–organic-framework nanozymes were employed to develop alkaline phosphatase assays with tunable dynamic ranges and colorimetric logic gates.

Graphical abstract: Phosphate-responsive 2D-metal–organic-framework-nanozymes for colorimetric detection of alkaline phosphatase
Paper

Morphology tunable and acid-sensitive dextran–doxorubicin conjugate assemblies for targeted cancer therapy

Morphology tunable and acid-sensitive dextran–doxorubicin conjugate assemblies (DD-M and DDF-V) were developed for targeted cancer therapy.

Graphical abstract: Morphology tunable and acid-sensitive dextran–doxorubicin conjugate assemblies for targeted cancer therapy
Paper

Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro

Hydrolytically stable, phototunable hybrid-hydrogels containing clickable decellularized extracellular matrix enable spatiotemporal control over fibroblast activation.

Graphical abstract: Clickable decellularized extracellular matrix as a new tool for building hybrid-hydrogels to model chronic fibrotic diseases in vitro
Paper

In vivo immunological response of exposure to PEGylated graphene oxide via intraperitoneal injection

2D PEGylated graphene oxide showed stealth-but-immune-activating capacity on macrophages, along with specific intraperitoneal immunological response in vivo.

Graphical abstract: In vivo immunological response of exposure to PEGylated graphene oxide via intraperitoneal injection
From the themed collection: Journal of Materials Chemistry B HOT Papers
Paper

Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy

We have reported a facile strategy to tune the photoconversion of organic dye aggregates for achieving potent photo-induced cancer therapy.

Graphical abstract: Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy
Paper

Self-assembly of paramagnetic amphiphilic copolymers for synergistic therapy

Theranostic nanoparticles composed of amphiphilic paramagnetic polymers are assembled for dual mode imaging and synergistic therapy.

Graphical abstract: Self-assembly of paramagnetic amphiphilic copolymers for synergistic therapy
Paper

Theranostics system caged in human serum albumin as a therapy for breast tumors

Biomimetic materials are attracting increasing attention in the field of drug delivery due to their low immunogenicity, good biocompatibility and degradability.

Graphical abstract: Theranostics system caged in human serum albumin as a therapy for breast tumors
Paper

Tumor-specific nanomedicine via sequential catalytic reactions for accurate tumor therapy

A tumor-targeting nanoreactor was developed to perform TME-triggered chain catalytic reactions and achieved satisfactory and accurate tumor therapy.

Graphical abstract: Tumor-specific nanomedicine via sequential catalytic reactions for accurate tumor therapy
44 items

About this collection

Journal of Materials Chemistry B is proud to present this themed issue highlighting 2020’s rising stars of materials chemistry research. This issue gathers the very best work from materials chemists in the early stages of their independent career.
Each contributor was recommended by experts in their fields as carrying out work with the potential to influence future directions in materials chemistry. Congratulations to all of those who feature on their important work so far in the field of materials for biology and medicine.

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