Jump to main content
Jump to site search
Access to RSC content Close the message box

Continue to access RSC content when you are not at your institution. Follow our step-by-step guide.



Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

Author affiliations

Abstract

Tumor-derived extracellular vesicles have emerged as an alternative source of cancer biomarkers in liquid biopsies. Despite their clinical potential, traditional methods for isolation and analysis have hampered their translation into the clinic. The use of nanomaterial-based biosensors can speed up the development of analytical methods for quantifying extracellular vesicles in a specific, highly reproducible, robust, fast and inexpensive way. Here we review the utility of extracellular vesicles as a novel type of liquid biopsies and the recent advances in nanoparticle-based biosensors for their analysis. We aim to emphasise the limitations and challenges that hinder extracellular vesicle analysis using these biosensors and point out potential solutions.

Graphical abstract: Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

Back to tab navigation

Article information


Submitted
01 Apr 2020
Accepted
02 Jun 2020
First published
04 Jun 2020

This article is Open Access

J. Mater. Chem. B, 2020, Advance Article
Article type
Review Article

Nanoparticle-based biosensors for detection of extracellular vesicles in liquid biopsies

B. Martín-Gracia, A. Martín-Barreiro, C. Cuestas-Ayllón, V. Grazú, A. Line, A. Llorente, J. M. de la Fuente and M. Moros, J. Mater. Chem. B, 2020, Advance Article , DOI: 10.1039/D0TB00861C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

Reproduced material should be attributed as follows:

  • For reproduction of material from NJC:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
  • For reproduction of material from PCCP:
    [Original citation] - Published by the PCCP Owner Societies.
  • For reproduction of material from PPS:
    [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
  • For reproduction of material from all other RSC journals:
    [Original citation] - Published by The Royal Society of Chemistry.

Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.


Social activity

Search articles by author

Spotlight

Advertisements