Photo-Degradable Micelles for Co-delivery of Nitric Oxide and Doxorubicin
The emerging therapeutic potentials of nitric oxide (NO) have spurred the rapid development of NO donors to maximize the therapeutic outcomes. Although polymeric NO donors have shown extended releasing times and optimized biodistributions, many of the previous macromolecular NO donors are non-degradable. Herein, we devise a macromolecular NO donor by integrating the photoresponsive N,N'-dinitroso-p-phenylenediamine (DNP) derivatives into the middle block of an amphiphilic triblock copolymer. The photo-mediated NO release process transforms the DNP to quinondimine (QDI) derivatives, enabling the degradation of the resulting polymers due to the spontaneous hydrolysis of QDI moieties. We demonstrated that the NO release process could be selectively activated by visible light irradiation both in vitro and in vivo. Moreover, photo-triggered simultaneous release of NO and DOX could be achieved by taking the advantage of the NO release-mediated micelle disassembly. This work provides new insights into the design of degradable macromolecular NO donors where the polymer breakdown could be actuated by triggered NO release.
- This article is part of the themed collection: Journal of Materials Chemistry B Emerging Investigators