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Themed collection Editor’s Choice – Ning Jiao

20 items
Open Access Perspective

Electro-organic synthesis – a 21st century technique

This perspective provides insight into recent electro-organic methods and general trends in this field, and opens up prospects for future viewpoints.

Graphical abstract: Electro-organic synthesis – a 21st century technique
From the themed collection: 2020 Chemical Science HOT Article Collection
Open Access Perspective

Tuning the stability of organic radicals: from covalent approaches to non-covalent approaches

Covalent and non-covalent approaches to tune the stability of organic radicals through steric effects and the delocalization of spin density.

Graphical abstract: Tuning the stability of organic radicals: from covalent approaches to non-covalent approaches
From the themed collection: Editor’s Choice – Jinlong Gong
Open Access Minireview

A happy medium: the synthesis of medicinally important medium-sized rings via ring expansion

Ring expansion strategies are ideally suited to make synthetically challenging, medium-sized rings with much potential in medicinal chemistry.

Graphical abstract: A happy medium: the synthesis of medicinally important medium-sized rings via ring expansion
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

Silyloxymethanesulfinate as a sulfoxylate equivalent for the modular synthesis of sulfones and sulfonyl derivatives

An efficient protocol for the modular synthesis of sulfones and sulfonyl derivatives has been developed utilizing sodium tert-butyldimethylsilyloxymethanesulfinate (TBSOMS-Na) as a sulfoxylate (SO22−) equivalent.

Graphical abstract: Silyloxymethanesulfinate as a sulfoxylate equivalent for the modular synthesis of sulfones and sulfonyl derivatives
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

A copper-catalyzed asymmetric oxime propargylation enables the synthesis of the gliovirin tetrahydro-1,2-oxazine core

The bicyclic tetrahydro-1,2-oxazine subunit of gliovirin is synthesized through a diastereoselective copper-catalyzed cyclization of an N-hydroxyamino ester.

Graphical abstract: A copper-catalyzed asymmetric oxime propargylation enables the synthesis of the gliovirin tetrahydro-1,2-oxazine core
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

Total synthesis of biseokeaniamides A–C and late-stage electrochemically-enabled peptide analogue synthesis

A late-stage electrochemical decarboxylation enables rapid access to structural analogues of biseokeaniamides A–C, cytotoxic lipopeptide natural products.

Graphical abstract: Total synthesis of biseokeaniamides A–C and late-stage electrochemically-enabled peptide analogue synthesis
From the themed collection: Celebrating 10 years of Chemical Science
Open Access Edge Article

Peptide late-stage C(sp3)–H arylation by native asparagine assistance without exogenous directing groups

An efficient method for peptide late-stage C(sp3)-H arylations assisted by unmodified side chain of asparagine (Asn) without any exogenous directing group has been reported.

Graphical abstract: Peptide late-stage C(sp3)–H arylation by native asparagine assistance without exogenous directing groups
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

Programmable synthesis of multiply arylated cubanes through C–H metalation and arylation

Cubane has attracted attention due to its unique 3D structure. Herein, we report the programmable synthesis of multiply arylated cubanes. The developed reaction allows the late-stage and regioselective installation of aryl groups.

Graphical abstract: Programmable synthesis of multiply arylated cubanes through C–H metalation and arylation
From the themed collection: Celebrating 10 years of Chemical Science
Open Access Edge Article

Palladium-catalyzed dearomative 1,4-difunctionalization of naphthalenes

The dearomative 1,4-difunctionalization of naphthalenes is achieved by imitating the reactivity of simple conjugated dienes in aromatic systems, providing functionalized spirooxindoles in high yields (up to 99%) with exclusive diastereoselectivity.

Graphical abstract: Palladium-catalyzed dearomative 1,4-difunctionalization of naphthalenes
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

Transferring axial molecular chirality through a sequence of on-surface reactions

The axial chirality of reactants is transferred through multistep on-surface reactions to chiral polymers and to prochiral graphene nanoribbons.

Graphical abstract: Transferring axial molecular chirality through a sequence of on-surface reactions
From the themed collection: 2020 Chemical Science HOT Article Collection
Open Access Edge Article

Facile access to diverse all-carbon quaternary center containing spirobicycles by exploring a tandem Castro–Stephens coupling/acyloxy shift/cyclization/semipinacol rearrangement sequence

An efficient construction of spirocyclo[4.5]decane derivatives is developed via a Castro–Stephens coupling/1,3-acyloxy shift/cyclization/semipinacol rearrangement sequence.

Graphical abstract: Facile access to diverse all-carbon quaternary center containing spirobicycles by exploring a tandem Castro–Stephens coupling/acyloxy shift/cyclization/semipinacol rearrangement sequence
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

Sulfoxide-mediated oxidative cross-coupling of phenols

A metal-free, oxidative coupling of phenols with various nucleophiles, including arenes, 1,3-diketones and other phenols, is reported.

Graphical abstract: Sulfoxide-mediated oxidative cross-coupling of phenols
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

Lipshutz-type bis(amido)argentates for directed ortho argentation

Bis(amido)argentate (TMP)2Ag(CN)Li2 was designed as a tool for highly chemoselective aromatic functionalization via unprecedented directed ortho argentation (DoAg).

Graphical abstract: Lipshutz-type bis(amido)argentates for directed ortho argentation
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

Controllable double CF2-insertion into sp2 C–Cu bond using TMSCF3: a facile access to tetrafluoroethylene-bridged structures

Copper-mediated controllable double CF2 insertion into sp2 C–Cu bond and subsequent cross-coupling reaction open the door to the synthesis of an array of valuable tetrafluoroethylene-bridged molecules.

Graphical abstract: Controllable double CF2-insertion into sp2 C–Cu bond using TMSCF3: a facile access to tetrafluoroethylene-bridged structures
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

Catalytic, transannular carbonyl-olefin metathesis reactions

Transannular carbonyl-olefin metathesis reactions complement existing procedures for related ring-closing, ring-opening, and intermolecular carbonyl-olefin metathesis. This enables molecular editing of steroid-derived frameworks.

Graphical abstract: Catalytic, transannular carbonyl-olefin metathesis reactions
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

Saturated oxygen and nitrogen heterocycles via oxidative coupling of alkyltrifluoroborates with alkenols, alkenoic acids and protected alkenylamines

The oxidative coupling of alkyltrifluoroborates with heteroatom-tethered vinylarenes leads to a broad range of saturated oxygen and nitrogen heterocycles.

Graphical abstract: Saturated oxygen and nitrogen heterocycles via oxidative coupling of alkyltrifluoroborates with alkenols, alkenoic acids and protected alkenylamines
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

Oxidant speciation and anionic ligand effects in the gold-catalyzed oxidative coupling of arenes and alkynes

The mechanism of the gold-catalyzed oxidative cross-coupling of arenes and alkynes has been studied in detail combining stoichiometric experiments with putative reaction intermediates and DFT calculations.

Graphical abstract: Oxidant speciation and anionic ligand effects in the gold-catalyzed oxidative coupling of arenes and alkynes
Open Access Edge Article

S8-Catalyzed triple cleavage of bromodifluoro compounds for the assembly of N-containing heterocycles

An unprecedented S8-catalyzed selective triple-cleavage of bromodifluoroacetamides is disclosed for the first time.

Graphical abstract: S8-Catalyzed triple cleavage of bromodifluoro compounds for the assembly of N-containing heterocycles
From the themed collection: Editor’s Choice – Ning Jiao
Open Access Edge Article

Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium

A general and practical method to directly convert phenols into primary anilines with cheap and easy-to-handle hydrazine as the amine and hydride sources catalyzed by Pd/C.

Graphical abstract: Direct conversion of phenols into primary anilines with hydrazine catalyzed by palladium
Open Access Edge Article

Aromatic C–H amination in hexafluoroisopropanol

We report direct amination of electron-poor arenes and evaluate the crucial factors for the enhanced reactivity in hexafluoroisopropanol.

Graphical abstract: Aromatic C–H amination in hexafluoroisopropanol
From the themed collection: Editor’s Choice – Ning Jiao
20 items

About this collection

In 2021, Chemical Science welcomed Professor Ning Jiao to the journal as an Associate Editor, handling papers in the area of organic chemistry. Ning has looked back over recent Chemical Science papers and has selected some outstanding articles that he would like to share, including research highlighting optimised total synthesis methodology, cross coupling reactions, and electro-organic synthesis. We hope you enjoy reading through this selection.

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