Themed collection Editor’s Choice – Ning Jiao

This perspective provides insight into recent electro-organic methods and general trends in this field, and opens up prospects for future viewpoints.

Covalent and non-covalent approaches to tune the stability of organic radicals through steric effects and the delocalization of spin density.

Ring expansion strategies are ideally suited to make synthetically challenging, medium-sized rings with much potential in medicinal chemistry.

An efficient protocol for the modular synthesis of sulfones and sulfonyl derivatives has been developed utilizing sodium tert-butyldimethylsilyloxymethanesulfinate (TBSOMS-Na) as a sulfoxylate (SO₂²⁻) equivalent.

The bicyclic tetrahydro-1,2-oxazine subunit of gliovirin is synthesized through a diastereoselective copper-catalyzed cyclization of an N-hydroxyamino ester.

A late-stage electrochemical decarboxylation enables rapid access to structural analogues of biseokeaniamides A–C, cytotoxic lipopeptide natural products.

An efficient method for peptide late-stage C(sp³)-H arylations assisted by unmodified side chain of asparagine (Asn) without any exogenous directing group has been reported.

Cubane has attracted attention due to its unique 3D structure. Herein, we report the programmable synthesis of multiply arylated cubanes. The developed reaction allows the late-stage and regioselective installation of aryl groups.

The dearomative 1,4-difunctionalization of naphthalenes is achieved by imitating the reactivity of simple conjugated dienes in aromatic systems, providing functionalized spirooxindoles in high yields (up to 99%) with exclusive diastereoselectivity.

The axial chirality of reactants is transferred through multistep on-surface reactions to chiral polymers and to prochiral graphene nanoribbons.

An efficient construction of spirocyclo[4.5]decane derivatives is developed via a Castro–Stephens coupling/1,3-acyloxy shift/cyclization/semipinacol rearrangement sequence.

A metal-free, oxidative coupling of phenols with various nucleophiles, including arenes, 1,3-diketones and other phenols, is reported.

Bis(amido)argentate (TMP)₂Ag(CN)Li₂ was designed as a tool for highly chemoselective aromatic functionalization via unprecedented directed ortho argentation (DoAg).

Copper-mediated controllable double CF₂ insertion into sp² C–Cu bond and subsequent cross-coupling reaction open the door to the synthesis of an array of valuable tetrafluoroethylene-bridged molecules.

Transannular carbonyl-olefin metathesis reactions complement existing procedures for related ring-closing, ring-opening, and intermolecular carbonyl-olefin metathesis. This enables molecular editing of steroid-derived frameworks.

The oxidative coupling of alkyltrifluoroborates with heteroatom-tethered vinylarenes leads to a broad range of saturated oxygen and nitrogen heterocycles.

The mechanism of the gold-catalyzed oxidative cross-coupling of arenes and alkynes has been studied in detail combining stoichiometric experiments with putative reaction intermediates and DFT calculations.

An unprecedented S₈-catalyzed selective triple-cleavage of bromodifluoroacetamides is disclosed for the first time.

A general and practical method to directly convert phenols into primary anilines with cheap and easy-to-handle hydrazine as the amine and hydride sources catalyzed by Pd/C.

We report direct amination of electron-poor arenes and evaluate the crucial factors for the enhanced reactivity in hexafluoroisopropanol.