Themed collection Food & Function HOT Articles 2023

The structure of instant powder foods is significantly influenced by their ingredients. Instant powder foods potentially can be formulated with functional or beneficial compounds to provide health benefits.

Ginger is a widespread source of herbal medicine and traditional spices.

Lycopene is an important pigment with an alkene skeleton from Lycopersicon esculentum, which is also obtained from some red fruits and vegetables.

Type 2 diabetes mellitus (T2DM) is one of the most prevalent diseases in modern society, governed by both genetic and environmental factors, such as nutritional habits. Dietary habits have a relevant impact on its development.

Steps of the NLRP3 inflammasome activation pathway where some selected polyphenols have shown a positive modulatory effect on different cardiometabolic alterations.

The study of all chemical processes involving metabolites is known as metabolomics.

We focus on summarizing the biological stability of miRNAs and its molecular mechanism in regulating the intestinal mucosa barrier.

Patients with Parkinson's disease (PD) demonstrate intestinal dysbiosis and substantial gastrointestinal dysfunction.

Each additional daily serving of UPF is associated with a 4% higher risk of CVEs and a 2% higher risk of total death. For maintaining good health, one should consume less UPF and more unprocessed or minimally processed food.

Urolithin-A drives the effects of pomegranate on the microbial metabolism of bile acids and cholesterol with possible consequences on human health.

Dietary α-ionone mitigates chronic UVB-induced skin photoaging by reducing wrinkles, alleviating dryness, promoting extracellular matrix, and inhibiting cellular senescence in mice.

A novel 3D-apical-out mouse enteroid model to investigate effects on the intestinal epithelium, including cytotoxicity, cell viability, and biotransformation. Evaluating the impact of prenylated phenolics from licorice (Glycyrrhiza) roots.

A novel anti-inflammatory peptide TPGAFF from quinoa protects impaired mucus barriers by inhibiting NF-κB-TRPV1 signaling and regulating the gut microbiota in DSS-induced colitis mice.

Thyme polyphenol-rich extract effectively mitigate HFD- induced NAFLD by modulating the gut-liver axis, specifically targeting the gut microbiota and bile acid metabolism.

The current study found that higher intake of dietary natural folate, but not synthetic folic acid intake from fortified foods, was associated with lower risks of all-cause mortality among chronic kidney disease (CKD) participants.

Low DM-pectins have strong anti-inflammatory effects and prevents dysregulation of TJ-related genes. The effects of pectin are dependent on DM of the pectin, the magnitude of TLR2 expression and on circulating sTLR2 in blood.

Astaxanthin supplementation altered the amino acid metabolism in tumor-bearing mice by modulating intestinal flora, thereby reducing the rate of skeletal muscle atrophy in tumor-bearing mice undergoing treatment.

Ganoderma lucidum methyl ganoderate E (MGE) improves healthspan and extends lifespan through the insulin/IGF-1 pathway, modulating neuroactive signaling and ubiquitin-mediated proteolysis.

Our findings provide evidence that macrophage pyroptosis contributes to the development of AAA and that the activation of the miR-146a/TRAF6 axis by pterostilbene protects against macrophage pyroptosis and AAA formation.

DATS ameliorated NNK-induced lung tumorigenesis by the modulation of gut microbiota and regulation of the PPARγ/NF-κB signaling pathway, thereby reducing the accumulation of inflammatory factors.

A new form of konjac fiber can instantaneously expand in the digestive tract and inhibit the digestion of the chyme.

Herein, the in vitro-simulated intestinal flora fermentation of Porphyra haitanensis polysaccharides with microwave, ultrasonic, ultra-high pressure-assisted extraction and their fermented products against HT-29 human colon cancer cells were studied.

Gerobiotic synergism reveals the secrets to healthy longevity in Caenorhabditis elegans.

Cognitive impairment is a significant concern in aging populations.

This study aimed to assess the inter-individual variation in phloretin absorption and metabolism and to seek possible phloretin metabotypes following apple snack consumption.

The dose-effect relationship between colonic perfusion of urolithin A and its anti-aging effect was investigated. Urolithin A inhibits NF-κB and mTOR targets to attenuate D-galactose-induced motor and cognitive decline.

Akkermansia muciniphila attenuated lipopolysaccharide-induced acute lung injury by modulating the gut microbiota and SCFAs in mice.

Dietary Lactobacillus rhamnosus GG extracellular vesicles (LGG-EV) synergistically enhanced anti-PD-1 immunotherapy efficacy against colorectal cancer. It was associated with improved tumor immunosuppressive environment, the abundance of beneficial bacteria and elevated specific serum metabolites.

β-Carbolines norharman and harman, belonging to the class of heterocyclic aromatic amines (HAAs), are typical hazardous substances produced during the thermal processing of food.

5 × FAD Alzheimer's disease male mice were treated orally with oligonol at a daily dose of 50 mg kg⁻¹ for 8 weeks. Oligonol oral treatment was found to improve cognitive function, and to reduce anxiety and depression in 5 × FAD Alzheimer's disease mouse.

Red wheat, aleurone, and testa reduce aberrant crypt foci and 3-nitrotyrosine and modify gut microbiome composition.

Key indicators of molecular docking related to taste intensity were specified in umami and bitter peptides to develop a rapid screening technique for taste peptides.

Anthocyanins and phlobaphenes enriched maize lines restored intestinal barrier function, mucosal integrity and modulated gut microbiota to display a protective effect against DSS-induced colitis.

Estimating (poly)phenol intake is challenging due to inadequate dietary assessment tools and limited food content data.

Since ulcerative colitis (UC) has become a global concern, Lactiplantibacillus is considered an effective, safe strategy for alleviating intestinal inflammation in UC patients.

Blended complementary foods from cereals and high-protein sources are used to cope with infants’ malnutrition. Our results demonstrate that a combination of strategies and technologies is needed to balance nutritional and physical quality.

Dietary diversity score, Healthy Food Diversity Index, and Healthy Eating Index were inversely associated with the risk of depressive symptoms.

Mangiferin effectively alleviated TMAO-induced atherosclerosis through its cholesterol-lowering, anti-inflammatory, and gut microbial modulatory activities in mice on a high-choline diet.

We established a hazelnut protein isolate (HPI)-allergic mouse model and the effects of HPI allergy on the duodenum, jejunum, ileum and colon microenvironment were investigated.

Curcumin has been proven to be an effective strategy for reducing inflammatory responses.

This study aimed to investigate the potential of xylooligosaccharides extracted from corn cobs in alleviating constipation and the mechanism of action in vivo.

Flavan-3-ols are important dietary bioactives. While fruits are significant sources of these compounds, fruit smoothies, particularly those with high levels of polyphenol oxidase, do not represent a viable option to increase flavan-3-ol intake.

Fermentation with Lactobacillus has been shown to improve the nutritional value of juice.

Differences between in vitro digestion protocols such as variations in pH, ionic strength, enzyme activity, and amount of gastric secretions result in modifications in the digesta properties of the same meal.

Gamma-aminobutyric acid (GABA) and fermented litchi juice enriched with GABA dietary interventions are considered to have therapeutic potential against obesity.

Selenium-enriched peptides identified from the hydrolysate alleviate heat damage by reducing intestinal epithelial cell permeability, protecting tight junction proteins, and regulating Nrf2-Keap1 and NLRP3 signaling pathways.

Utilizing protein blends improved the amino acid profile of the ingredients, and extrusion processing effectively reduced trypsin inhibitors in all extrudates but only enhanced the in vitro protein digestibility of the pulse-rich extrudates.

Sea cucumber chondroitin sulfate polysaccharides can attenuate OVA-induced food allergy in BALB/c mice, which associated with gut microbiota metabolism and Treg cell differentiation.

The current randomized, double-blind, placebo-controlled trial showed that Lacticaseibacillus paracasei strain Shirota supplementation improved non-motor symptoms and specific gastrointestinal symptoms in Parkinson's disease patients.

The release pattern and structural characteristics of bitter peptides affected the bitterness increase behaviors of casein hydrolysates. A high-digestibility and low-bitterness casein hydrolysate was obtained.

Water kefir microbiota exerted preventive roles in DSS-induced colitis by modulating the expression of tight junction proteins, reducing inflammation via inactivating the NF-κB signaling pathway, and regulating microbial dysbiosis.

BRS Moema showed considerable quantities of capsiate and phenolic compounds (in free, esterified, glycosylated, and insoluble-bound forms) quantified by UHPLC-ESI-MS/MS.

Spectroscopic and simulation methods were used to report the binding behavior and antioxidant activity of piperine with respect to myoglobin and to explain the effects of piperine on protein structure.

A significant correlation between decreased levels of leucine and social avoidance behavior utilized a combination of untargeted and targeted metabolomics. The supplementation of leucine has a positive impact on social avoidance behavior.

Lactiplantibacillus plantarum ZDY2013 shows a colonization niche preference and interacts with the food-borne pathogen Bacillus cereus in the complex gut environment.

Clinical evidence suggests that a bidirectional relationship is present between sleep loss and psychiatric disorders.

Inhibition of α-glucosidases can slow carbohydrate digestion to reduce postprandial glycaemia and lower risk of type 2 diabetes. Our systematic review found no studies that tested the inhibitory potential of nut extracts against human α-glucosidases.

Rd regulates fibrogenesis and inflammatory responses in hepatic fibrosis by mediating the ERRα-P2X7r signaling pathway.

SMEOs was extracted by MAHD, the composition of SMEOs was identified and analyzed by GC-MS. SMEOs was loaded into MSNPs to evaluate its sustained release activity, and the anti-inflammatory activity of SMEOs in vivo was determined.

Study on the urinary excretion of organosulfur compounds after acute ingestion of black onion, a newly derived product from onion (Allium cepa L.).

PLA is vital to the effective suppression of H. pylori growth and the prevention of gastritis by reducing oxidative stress, improving gastrointestinal microbiota, and mitigating inflammatory responses.

The abnormal accumulation of fused in sarcoma (FUS) is a pathological hallmark in a proportion of patients with frontotemporal dementia and amyotrophic lateral sclerosis.

This study aimed to investigate the impact of chitosan-grafted-caffeic acid (CS-g-CA) and ultrasound (US) on myofibrillar proteins (MPs) in pompano (Trachinotus ovatus) during 24 days of ice storage.

Physiological parameters of the static in vitro digestion model adapted to the general older adult.

MOLP demonstrate anti-Lewis lung cancer effects by reversing the tumor-associated macrophage phenotype and restoring T-cell function.

The current study focused on modulating the structures of zein-based emulsion gels by the addition of a surface active ingredient (Span 20, SP) to improve textural and digestion behaviors.

This study aimed to investigate the potential neuroprotective effects of Lycium ruthenicum polyphenols (LRP) against acrylamide (ACR)-induced neurotoxicity and the mechanism of action in vitro and in vivo.

The LJP61A suppressed macrophage foam cell formation and atherosclerotic progression by modulating Ca²⁺-calpain mediated autophagy inhibition.

Citrate-coated cobalt ferrite nanoparticles enhance wheat's nutritional quality by improving grain yield and increasing Fe concentration, contributing to sustainable agri-food systems and combating hidden hunger.

This study aimed to investigate the anti-inflammatory effects of ellagitannins from black raspberry seeds in vivo and the structural effects of ellagitannins on glucagon-like peptide-1 secretion and mouse bitter taste receptor (mTAS2R).