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Themed collection C-H Functionalization

28 items
Perspective

Ruthenium-catalyzed direct oxidative alkenylation of arenes through twofold C–H bond functionalization

Significant progress has been accomplished in direct olefinations through twofold C–H bond functionalization of arenes and heteroarenes employing readily accessible, selective and inexpensive ruthenium(II) catalysts.

Graphical abstract: Ruthenium-catalyzed direct oxidative alkenylation of arenes through twofold C–H bond functionalization
From the themed collection: C-H Functionalization
Minireview

Catalytic enantioselective carbon-carbon bond formation using cycloisomerization reactions

We present a review highlighting advancements in the field of asymmetric cycloisomerization reactions which, due to significant improvements occurring in the last twenty years, efficiently produce diverse polycyclic compounds with excellent selectivity.

Graphical abstract: Catalytic enantioselective carbon-carbon bond formation using cycloisomerization reactions
From the themed collection: C-H Functionalization
Review Article

Oxidative C–H amination reactions

Towards “Oxidative-Ullmann–Goldberg” and “Oxidative-Buchwald–Hartwig” type amination reactions.

Graphical abstract: Oxidative C–H amination reactions
From the themed collection: C-H Functionalization
Review Article

sp2 C–H bond activation in water and catalytic cross-coupling reactions

This review gathers metal-catalysed sp2 C–H bond activation reactions in water for C–C bond cross-couplings and shows the partnership of water to increase the catalyst activity.

Graphical abstract: sp2 C–H bond activation in water and catalytic cross-coupling reactions
From the themed collection: C-H Functionalization
Tutorial Review

Methane as raw material in synthetic chemistry: the final frontier

The activation and catalytic functionalization of methane are reviewed showing that this area requires further and urgent development in the incoming years.

Graphical abstract: Methane as raw material in synthetic chemistry: the final frontier
From the themed collection: C-H Functionalization
Tutorial Review

Cyclometalative C–H bond activation in rare earth and actinide metal complexes

Ligand cyclometalative C–H bond activation in rare earth and actinide complexes is discussed. The scope is intended to outline routine cases, while also highlighting exceptional cyclometalation reactions that lead to unusual bonding modes.

Graphical abstract: Cyclometalative C–H bond activation in rare earth and actinide metal complexes
From the themed collection: C-H Functionalization
Tutorial Review

From C(sp2)–H to C(sp3)–H: systematic studies on transition metal-catalyzed oxidative C–C formation

Our recent developments in transition metal-catalyzed oxidative coupling via C–H functionalization of aromatic, benzylic and allylic C–H bonds is summarized.

Graphical abstract: From C(sp2)–H to C(sp3)–H: systematic studies on transition metal-catalyzed oxidative C–C formation
From the themed collection: C-H Functionalization
Tutorial Review

A walk around the A3-coupling

This tutorial review aims to highlight the current achievements in the field of A3-couplings and related transformations.

Graphical abstract: A walk around the A3-coupling
From the themed collection: C-H Functionalization
Critical Review

Progress in palladium-based catalytic systems for the sustainable synthesis of annulated heterocycles: a focus on indole backbones

Ligand chemistry has given a significant impetus to produce functionalized indoles by assisting novel powerful palladium-catalysed intra- and intermolecular cyclizations.

Graphical abstract: Progress in palladium-based catalytic systems for the sustainable synthesis of annulated heterocycles: a focus on indole backbones
From the themed collection: C-H Functionalization
Critical Review

C–C, C–O and C–N bond formation via rhodium(III)-catalyzed oxidative C–H activation

Rh(III) catalysts readily catalyze the oxidative C–H activation of arenes under chelation assistance, leading to C–C, C–N, and C–O bond formation.

Graphical abstract: C–C, C–O and C–N bond formation via rhodium(iii)-catalyzed oxidative C–H activation
From the themed collection: C-H Functionalization
Critical Review

Recent advances in transition metal-catalyzed sp3 C–H amination adjacent to double bonds and carbonyl groups

C–H amination has become a viable method for the efficient installation of nitrogen atoms en route to allyl amines and α-amino carbonyl compounds.

Graphical abstract: Recent advances in transition metal-catalyzed sp3 C–H amination adjacent to double bonds and carbonyl groups
From the themed collection: C-H Functionalization
Communication

A room temperature decarboxylation/C–H functionalization cascade by visible-light photoredox catalysis

A room temperature decarboxylation/C–H functionalization cascade has been developed for concise construction of quaternary oxindoles by means of visible-light photoredox catalysis.

Graphical abstract: A room temperature decarboxylation/C–H functionalization cascade by visible-light photoredox catalysis
From the themed collection: C-H Functionalization
Communication

Pd(II)-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C–H bond activation

A palladium-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C–H bond activation is described.

Graphical abstract: Pd(ii)-catalyzed decarboxylative acylation of phenylacetamides with α-oxocarboxylic acids via C–H bond activation
From the themed collection: C-H Functionalization
Communication

Pd-catalyzed double C–H bond activation of diaryl ketones for the synthesis of fluorenones

An efficient synthesis of fluorenones from diaryl ketones by Pd-catalyzed oxidative cyclization is described. A possible mechanism involving a carbonyl group assisted ortho-C–H activation and cyclometalation followed by a second C–H activation to form a six-membered palladacycle and reductive elimination is proposed.

Graphical abstract: Pd-catalyzed double C–H bond activation of diaryl ketones for the synthesis of fluorenones
From the themed collection: C-H Functionalization
Communication

I2 promoted domino oxidative cyclization for one-pot synthesis of 2-acylbenzothiazoles via metal-free sp3 C–H functionalization

An I2 promoted iodination, Kornblum oxidation, and annulation domino protocol was developed to construct 2-acylbenzothiazoles from aromatic ketones and o-aminobenzenethiols.

Graphical abstract: I2 promoted domino oxidative cyclization for one-pot synthesis of 2-acylbenzothiazoles via metal-free sp3 C–H functionalization
From the themed collection: C-H Functionalization
Communication

Palladium-catalyzed direct arylation of benzoxazoles with unactivated simple arenes

Using CuBr2 as an additive, the Pd-catalyzed intermolecular C–H–C–H cross-coupling between benzoxazoles and unactivated simple arenes has been developed.

Graphical abstract: Palladium-catalyzed direct arylation of benzoxazoles with unactivated simple arenes
From the themed collection: C-H Functionalization
Communication

Catalytic oxidation/C–H functionalization of N-arylpropiolamides by means of gold carbenoids: concise route to 3-acyloxindoles

A one-step efficient synthesis of 3-acyloxindole derivatives was developed with extremely good substrate scope and significant opportunities for structural diversification.

Graphical abstract: Catalytic oxidation/C–H functionalization of N-arylpropiolamides by means of gold carbenoids: concise route to 3-acyloxindoles
From the themed collection: C-H Functionalization
Communication

Unprecedented synthesis of iron–NHC complexes by C–H activation of imidazolium salts. Mild catalysts for reduction of sulfoxides

A direct synthesis of iron–NHC complexes by C–H activation of the corresponding imidazolium salts with commercially available Fe3(CO)12.

Graphical abstract: Unprecedented synthesis of iron–NHC complexes by C–H activation of imidazolium salts. Mild catalysts for reduction of sulfoxides
From the themed collection: C-H Functionalization
Communication

Cobalt-catalyzed arylation of aldiminesvia directed C–H bond functionalization: addition of 2-arylpyridines and self-coupling of aromatic aldimines

A cobalt–N-heterocyclic carbene catalyst promotes a chelation-assisted aromatic C–H functionalization reaction via addition to an aromatic aldimine.

Graphical abstract: Cobalt-catalyzed arylation of aldimines via directed C–H bond functionalization: addition of 2-arylpyridines and self-coupling of aromatic aldimines
From the themed collection: C-H Functionalization
Communication

Palladium-catalyzed deamidative arylation of azoles with arylamides through a tandem decarbonylation–C–H functionalization

A highly chemo-, regio-selective, and efficient palladium-catalyzed deamidative arylation of azoles with arylamides was developed via a tandem decarbonylation–C–H activation.

Graphical abstract: Palladium-catalyzed deamidative arylation of azoles with arylamides through a tandem decarbonylation–C–H functionalization
From the themed collection: C-H Functionalization
Communication

Fe-catalysed oxidative C–H functionalization/C–S bond formation

Iron served as the catalyst for the direct C–H functionalization/C–S bond formation to afford benzothiazoles under mild conditions.

Graphical abstract: Fe-catalysed oxidative C–H functionalization/C–S bond formation
From the themed collection: C-H Functionalization
Edge Article

Organocatalytic C–H hydroxylation with Oxone® enabled by an aqueous fluoroalcohol solvent system

Selective hydroxylation of 3° and benzylic C–H bonds is made possible using a non-metal-based catalyst system, Oxone as the terminal oxidant, and an aqueous fluoroalcohol solvent mixture.

Graphical abstract: Organocatalytic C–H hydroxylation with Oxone® enabled by an aqueous fluoroalcohol solvent system
From the themed collection: C-H Functionalization
Edge Article

Rh(III)-catalyzed C–H activation–desymmetrization of diazabicycles with arenes: facile synthesis of functionalized cyclopentenes

A Rh(III)-catalyzed C–H activation–desymmetrization of diazabicycles with arenes as an expedient approach to functionalized cyclopentenes is reported.

Graphical abstract: Rh(iii)-catalyzed C–H activation–desymmetrization of diazabicycles with arenes: facile synthesis of functionalized cyclopentenes
From the themed collection: C-H Functionalization
Edge Article

Rh(III)-catalyzed C–H activation/cycloaddition of benzamides and methylenecyclopropanes: divergence in ring formation

An unprecedented Rh(III)-catalyzed cyclization of benzamides and methylenecyclopropanes for the divergent synthesis of privileged heterocycles is reported.

Graphical abstract: Rh(iii)-catalyzed C–H activation/cycloaddition of benzamides and methylenecyclopropanes: divergence in ring formation
From the themed collection: C-H Functionalization
Edge Article

Iridium(III)-bis(oxazolinyl)phenyl catalysts for enantioselective C–H functionalization

A family of iridium(III)-bis(oxazolinyl)phenyl complexes has been developed to catalyze enantioselective C-H functionalization reactions. DFT studies provide evidence for an axially bound carbene and provide a unique model for stereoinduction in atom transfer reactions employing bis(oxazolinyl)phenyl ligands.

Graphical abstract: Iridium(iii)-bis(oxazolinyl)phenyl catalysts for enantioselective C–H functionalization
From the themed collection: C-H Functionalization
Edge Article

A metal–amide dependent, catalytic C–H functionalisation of triphenylphosphonium methylide

We report the [Y{N(SiMe3)2}3] catalysed dehydrocoupling of triphenylphosphonium methylide with phenylsilane to form the silylated ylide Ph3PCHSiH2Ph.

Graphical abstract: A metal–amide dependent, catalytic C–H functionalisation of triphenylphosphonium methylide
From the themed collection: C-H Functionalization
Edge Article

Visible-light-mediated photochemistry: accelerating Ru(bpy)32+-catalyzed reactions in continuous flow

The first application of visible-light-mediated synthetic photochemistry in continuous flow is described. Using an operationally simple photoreactor design, several Ru(bpy)32+-catalyzed transformations were performed with 10–50 fold rate enhancement over the corresponding batch methods.

Graphical abstract: Visible-light-mediated photochemistry: accelerating Ru(bpy)32+-catalyzed reactions in continuous flow
From the themed collection: C-H Functionalization
Edge Article

Palladium(0)-catalyzed cyclopropane C–H bond functionalization: synthesis of quinoline and tetrahydroquinoline derivatives

Quinolines and tetrahydroquinolines were prepared from a common precursor through Pd(0)-catalyzed cyclopropane C–H bond functionalization.

Graphical abstract: Palladium(0)-catalyzed cyclopropane C–H bond functionalization: synthesis of quinoline and tetrahydroquinoline derivatives
From the themed collection: C-H Functionalization
28 items

About this collection

This collection showcases some of the most cited research papers and reviews published in ChemSocRev, Chemical Science and ChemComm in the area of C-H functionalization.

The collection will be free to access* from the 10th March - 4th April 2014.

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